TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii

Autor: Asma S. Khelifa, Cecilia Guillen Sanchez, Kevin M. Lesage, Ludovic Huot, Thomas Mouveaux, Pierre Pericard, Nicolas Barois, Helene Touzet, Guillemette Marot, Emmanuel Roger, Mathieu Gissot

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

The control of the proper timing of emergence of apicomplexan parasite daughter cells during replication is crucial for their proliferation. Here, Khelifa et al. identify a key transcriptional regulator in the model Apicomplexa Toxoplasma gondii, whi

Externí odkaz: https://doaj.org/article/1314f9ac2f0c45b4ad814b41afd09d19

Analysis of the interactome of Schistosoma mansoni histone deacetylase 8.

Autor: Stéphanie Caby, Lucile Pagliazzo, Julien Lancelot, Jean-Michel Saliou, Nicolas Bertheaume, Raymond J Pierce, Emmanuel Roger

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 11, p e0006089 (2017)

Histone deacetylase 8 from Schistosoma mansoni (SmHDAC8) is essential to parasite growth and development within the mammalian host and is under investigation as a target for the development of selective inhibitors as novel schistosomicidal drugs. Alt

Externí odkaz: https://doaj.org/article/696e0eac389341a382c3a8c4bcd14d61

Chromatin regulation in schistosomes and histone modifying enzymes as drug targets

Autor: Raymond John Pierce, Florence Dubois-Abdesselem, Stéphanie Caby, Jacques Trolet, Julien Lancelot, Frédérik Oger, Nicolas Bertheaume, Emmanuel Roger

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 7, Pp 794-801 (2011)

Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objectiv

Externí odkaz: https://doaj.org/article/cfa524fa51d14dedb3f20feab275eb4f

Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata).

Autor: Emmanuel Roger, Christoph Grunau, Raymond J Pierce, Hirohisa Hirai, Benjamin Gourbal, Richard Galinier, Rémi Emans, Italo M Cesari, Céline Cosseau, Guillaume Mitta

Publikováno v: PLoS Neglected Tropical Diseases, Vol 2, Iss 11, p e330 (2008)

Invertebrates were long thought to possess only a simple, effective and hence non-adaptive defence system against microbial and parasitic attacks. However, recent studies have shown that invertebrate immunity also relies on immune receptors that dive

Externí odkaz: https://doaj.org/article/caf0c67ca3c047f3965f86ac598edbf7

Primary brain cell infection by Toxoplasma gondii reveals the extent and dynamics of parasite differentiation and its impact on neuron biology

Autor: Fanny Eysert, Jean-Charles Lambert, Alioune Gueye, Mathieu Gissot, Emmanuel Roger, Benjamin Grenier-Boley, Thomas Mouveaux, Ludovic Huot

Publikováno v: Open Biology
Open Biology, 2021, 11 (10), pp.210053. ⟨10.1098/rsob.210053⟩
Open Biology, Vol 11, Iss 10 (2021)
Open Biology, Royal Society, 2021, 11 (10), pp.210053. ⟨10.1098/rsob.210053⟩

Toxoplasma gondii is a eukaryotic parasite that forms latent cysts in the brain of immunocompetent individuals. The latent parasite infection of the immune-privileged central nervous system is linked to most complications. With no drug currently avai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3a9eca1e6e2eaf7c4517b450a5649c
https://hal.science/hal-03367209