Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Emmanuel R. Yera"'
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000700 (2010)
Functionally analogous enzymes are those that catalyze similar reactions on similar substrates but do not share common ancestry, providing a window on the different structural strategies nature has used to evolve required catalysts. Identification an
Externí odkaz:
https://doaj.org/article/312f6159d3ed44e7988ba47233404af3
Publikováno v:
Yera, ER; Cleves, AE; & Jain, AN. (2014). Prediction of off-target drug effects through data fusion. 19th Pacific Symposium on Biocomputing, PSB 2014, 160-171. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8bn506kn
Pacific Symposium on Biocomputing
Pacific Symposium on Biocomputing
We present a probabilistic data fusion framework that combines multiple computational approaches for drawing relationships between drugs and targets. The approach has special relevance to identifying surprising unintended biological targets of drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c9ea35e26b152c5319a22ca1c74a35
https://escholarship.org/uc/item/8bn506kn
https://escholarship.org/uc/item/8bn506kn
Publikováno v:
Journal of medicinal chemistry. 54(19)
Drug structures may be quantitatively compared based on 2D topological structural considerations and based on 3D characteristics directly related to binding. A framework for combining multiple similarity computations is presented along with its syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36602f8b2781f1e92fc48b5a916f7a6
https://pubmed.ncbi.nlm.nih.gov/21916467
https://pubmed.ncbi.nlm.nih.gov/21916467
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000700 (2010)
PLoS computational biology, vol 6, iss 3
PLoS Computational Biology
PLoS computational biology, vol 6, iss 3
PLoS Computational Biology
Functionally analogous enzymes are those that catalyze similar reactions on similar substrates but do not share common ancestry, providing a window on the different structural strategies nature has used to evolve required catalysts. Identification an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabdc56caca29ed63546e8fec5077f9e
http://europepmc.org/articles/PMC2837397?pdf=render
http://europepmc.org/articles/PMC2837397?pdf=render
Autor:
Howard L. Adler, Qiang Zhao, Emmanuel R. Yera, Jeffry P. Simko, Tina Fan, Wen-Tien Chen, Stanley Zucker, Pamela L. Paris, Jonathan E. Rosenberg, Wei Zeng, Yasuko Kobayashi, Mohammad H. Zarrabi, Shivaranjani Sridharan
Publikováno v:
Cancer letters. 277(2)
Circulating tumor cells (CTCs) hold promise for studying advanced prostate cancer. A functional collagen adhesion matrix (CAM) assay was used to enrich CTCs from prostate cancer patients' blood. CAM ingestion and epithelial immuno-staining identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0d456f66eec72b3ff0c2c4b1722961
https://pubmed.ncbi.nlm.nih.gov/19162393
https://pubmed.ncbi.nlm.nih.gov/19162393
Publikováno v:
BIBE
Discerning the similarity between two molecules is a challenging problem in drug discovery as well as in molecular biology. The importance of this problem is due to the fact that the biochemical characteristics of a molecule are closely related to it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0be3eb8dd457b688c773a39fcd1c4cc
https://doi.org/10.1109/bibe.2006.253343
https://doi.org/10.1109/bibe.2006.253343
Publikováno v:
CBMS
The state of the art in modern drug discovery involves investigating a large number of drug-like molecules using medium or high-throughput assays, often being conducted against multiple targets. Managing the information generated in such processes re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a392a726475a9ec3d7adfb7be6ace1e
https://doi.org/10.1109/cbms.2006.89
https://doi.org/10.1109/cbms.2006.89