Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Emmanuel Pinard"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2035-2064 (2018)
The focus of this review is to provide an overview of the field of organocatalysed photoredox chemistry relevant to synthetic medicinal chemistry. Photoredox transformations have been shown to enable key transformations that are important to the phar
Externí odkaz:
https://doaj.org/article/936ff9c822824105b15842b346984683
Publikováno v:
CHIMIA, Vol 72, Iss 7-8 (2018)
Glycine transporter-1 (GlyT1) inhibition has been extensively studied both in pharmaceutical companies and academic institutions primarily as a potential new approach to treat schizophrenia, a severe and chronic mental illness. More recently, preclin
Externí odkaz:
https://doaj.org/article/8c0a3d50696a46f38ab15715e29fc2a6
Autor:
Bernd Buettelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler
Publikováno v:
CHIMIA, Vol 58, Iss 9 (2004)
A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists tha
Externí odkaz:
https://doaj.org/article/e78b5258c9904237b4bbb3f669504de2
Autor:
Roger J. P. Dawson, Emmanuel Pinard, Poul Nissen, Gleb Bourenkov, Wolfgang Guba, Azadeh Shahsavar, Peter Stohler, Thomas R. Schneider, Markus A. Seeger, Martin Siegrist, Iwan Zimmermann
The human glycine transporter 1 (GlyT1) regulates glycine mediated neuronal excitation and inhibition through sodium- and chloride-dependent reuptake of the neurotransmitter1-3. Inhibition of glycine reuptake via GlyT1 prolongs neurotransmitter signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510a4015d88ead692ea0fc106d6c1255
https://doi.org/10.1101/2020.12.20.110478
https://doi.org/10.1101/2020.12.20.110478
Autor:
Wolfgang Guba, Markus A. Seeger, Azadeh Shahsavar, Iwan Zimmermann, Thomas R. Schneider, Steffen Sinning, Gleb Bourenkov, Emmanuel Pinard, Poul Nissen, Peter Stohler, Martin Siegrist, Roger J. P. Dawson
Publikováno v:
Shahsavar, A, Stohler, P, Bourenkov, G, Zimmermann, I, Siegrist, M, Guba, W, Pinard, E, Sinning, S, Seeger, M A, Schneider, T R, Dawson, R J P & Nissen, P 2021, ' Structural insights into the inhibition of glycine reuptake ', Nature, vol. 591, pp. 677-681 . https://doi.org/10.1038/s41586-021-03274-z
The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation and inhibition through the sodium- and chloride-dependent reuptake of glycine1–3. Inhibition of GlyT1 prolongs neurotransmitter signalling, and has long been a k
Autor:
Schnider Patrick, Erwin Goetschi, Neil Parrott, Hasane Ratni, Markus von Kienlin, Basil Künnecke, Celine Risterucci, Cosimo Dolente, Mark Rogers-Evans, Roland Jakob-Roetne, Christophe Grundschober, Andreas Bruns, Caterina Bissantz, Emmanuel Pinard, Wolfgang Muster, Thomas Mueggler
Publikováno v:
Journal of medicinal chemistry. 63(4)
We recently reported the discovery of a potent, selective, and brain-penetrant V1a receptor antagonist, which was not suitable for full development. Nevertheless, this compound was found to improve surrogates of social behavior in adults with autism
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2035-2064 (2018)
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2035-2064 (2018)
The focus of this review is to provide an overview of the field of organocatalysed photoredox chemistry relevant to synthetic medicinal chemistry. Photoredox transformations have been shown to enable key transformations that are important to the phar
Autor:
Tianle Yang, Hasane Ratni, Emmanuel Pinard, Nanjing Zhang, Hongyan Qi, Nikolai Naryshkin, Priya Vazirani, Stephan Kirchner, Xiaoyan Zhang, Karen S. Chen, Amal Dakka, Lutz Mueller, Friedrich Metzger, Woll Matthew G, Sergey Paushkin, Xin Zhao, Marla Weetall, Gary Mitchell Karp, Kathleen D. McCarthy, Agnès Poirier, Wolfgang Muster, Pascale David-Pierson, Luke Green, Irene Gerlach, Anthony Turpoff, Dietrich Tuerck
Publikováno v:
Journal of Medicinal Chemistry. 59:6086-6100
Spinal muscular atrophy (SMA) is the leading genetic cause of infant and toddler mortality, and there is currently no approved therapy available. SMA is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. These mutations or del
Autor:
Martin Stahl, Jérôme Hert, Werner Neidhart, Wolfgang Haap, Bernd Kuhn, Wolfgang Guba, Patrizio Mattei, Markus G. Rudolph, Christian Lerner, Matthias Körner, David Banner, Emmanuel Pinard, Andreas Kuglstatter, Tanja Schulz-Gasch, Caterina Bissantz, Simona M. Ceccarelli, Thomas Johannes Woltering
Publikováno v:
Journal of Medicinal Chemistry. 59:4087-4102
We present a series of small molecule drug discovery case studies where computational methods were prospectively employed to impact Roche research projects, with the aim of highlighting those methods that provide real added value. Our brief accounts
Publikováno v:
CHIMIA, Vol 72, Iss 7-8 (2018)
Glycine transporter-1 (GlyT1) inhibition has been extensively studied both in pharmaceutical companies and academic institutions primarily as a potential new approach to treat schizophrenia, a severe and chronic mental illness. More recently, preclin