Zobrazeno 1 - 10 of 62 pro vyhledávání: '"Emmanuel Pfund"'
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Akademický článek
Selective preparation of tetrasubstituted fluoroalkenes by fluorine-directed oxetane ring-opening reactions
Autor: Clément Q. Fontenelle, Thibault Thierry, Romain Laporte, Emmanuel Pfund, Thierry Lequeux
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1936-1946 (2020)
The selective ring-opening reaction of fluoroalkylidene-oxetanes was directed by the presence of the fluorine atom, enabling a two-step access to tetrasubstituted fluoroalkenes with excellent geometry control. Despite its small van der Waals radii el
Externí odkaz: https://doaj.org/article/20041979a26d4d418dee9f4741809e07
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3
Selective preparation of tetrasubstituted fluoroalkenes by fluorine-directed oxetane ring-opening reactions
Autor: Thibault Thierry, Thierry Lequeux, Clément Q Fontenelle, Emmanuel Pfund, Romain Laporte
Publikováno v: Beilstein J. Org. Chem
Beilstein J. Org. Chem, 2020, 16, pp.1936-1946. ⟨10.3762/bjoc.16.160⟩
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1936-1946 (2020)
Beilstein Journal of Organic Chemistry
International audience; The selective ring-opening reaction of fluoroalkylidene-oxetanes was directed by the presence of the fluorine atom, enabling a two-step access to tetrasubstituted fluoroalkenes with excellent geometry control. Despite its smal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6909cfd08ebd0024c31cfacb2065b686
https://doi.org/10.3762/bjoc.16.160
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4
Convergent access to mono-fluoroalkene-based peptidomimetics
Autor: Florent Larnaud, Charlène Calata, Anaïs Prunier, Clothilde Le Guen, Rémi Legay, Emmanuel Pfund, Thierry Lequeux
Publikováno v: Organicbiomolecular chemistry. 20(6)
Expeditive racemic synthesis of monofluoroalkene peptide isosteres from aldehydes and substituted aromatic sulfones is reported. The olefination reaction is highly Z-selective from substituted aldehydes to afford transoid peptide mimic precursors.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35fd6db469b7156bc69177fb3a927bc
https://pubmed.ncbi.nlm.nih.gov/35075471
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6
Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y
Autor: Thierry Lequeux, Emmanuel Pfund, Thibault Thierry
Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2021, 27 (60), pp.14826-14830. ⟨10.1002/chem.202102124⟩
A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73e00c851e9960a5b45531951ef020e
https://pubmed.ncbi.nlm.nih.gov/34464004
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7
Genetic and pharmacological inactivation of d-alanylation of teichoic acids sensitizes pathogenic enterococci to β-lactams
Autor: Loïc Léger, Aurélie Budin-Verneuil, Emmanuel Pfund, Thierry Lequeux, Abdellah Benachour, Delphine Coupri, Axel Hartke, Nicolas Verneuil
Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2019, 74 (11), pp.3162-3169. ⟨10.1093/jac/dkz322⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2019, ⟨10.1093/jac/dkz322⟩
BackgroundEnterococci intrinsically resistant to cephalosporins represent a major cause of healthcare-associated infections, and the emergence of MDR makes therapeutic approaches particularly challenging.ObjectivesTeichoic acids are cell wall glycopo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cbdbcdcc29103395856fa00285bd82
https://doi.org/10.1093/jac/dkz322
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8
Difluorophosphonylated Allylic Ether Moiety as a 2′-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies
Autor: Jean-Jacques Vasseur, Sonia Rouanet, Christelle Dupouy, Emmanuel Pfund, Rémi Legay, Thierry Lequeux, Cyril Lebargy
Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2019, 21 (12), pp.4803-4807. ⟨10.1021/acs.orglett.9b01689⟩
The first synthesis of oligonucleotides incorporating URF, a uridine modified with a difluorophosphonylated allylic ether onto the 2'-position, is described. Fluorinated homouridylates and miR-342-3p analogues are efficiently prepared. UV-melting exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3032e109ac977bfd1015c3e8aa14371
https://doi.org/10.1021/acs.orglett.9b01689
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9
Inhibition of d-alanylation of teichoic acids overcomes resistance of methicillin-resistant Staphylococcus aureus
Autor: Delphine, Coupri, Nicolas, Verneuil, Axel, Hartke, Axelle, Liebaut, Thierry, Lequeux, Emmanuel, Pfund, Aurélie, Budin-Verneuil
Publikováno v: Journal of Antimicrobial Chemotherapy
Background MRSA are high-priority multidrug-resistant pathogens. Although there are still some antibiotics active against MRSA, continuous efforts to discover new antibiotics and treatment strategies are needed because resistance to these new drugs h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28bfba648d73bba3ab212436b0c43bda
https://pubmed.ncbi.nlm.nih.gov/34450626
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10
Synthesis of Fluoropyrrolidines and (Fluoroalkyl)pyrrolidines
Autor: Thierry Lequeux, Emmanuel Pfund
Publikováno v: SYNTHESIS
SYNTHESIS, Georg Thieme Verlag, 2017, 49 (17), pp.3848-3862. ⟨10.1055/s-0036-1589078⟩
Pyrrolidines and their derivatives are of great interest in medicinal chemistry and organic synthesis. Fluoropyrrolidines and (fluoroalkyl)pyrrolidines have been utilized in the preparation of medicinal drugs and also as organocatalysts. The synthesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6dfc2085163a268c81e4cfe8c81653
https://doi.org/10.1055/s-0036-1589078
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