Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Emmanuel M. Landau"'
Publikováno v:
The Journal of Neuroscience. 27:5885-5894
Protein synthesis is required for persistent forms of synaptic plasticity, including long-term potentiation (LTP). A key regulator of LTP-related protein synthesis is mammalian target of rapamycin (mTOR), which is thought to modulate translational ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91d7bd34174e21a9e98c0277da3de7b
https://doi.org/10.1523/jneurosci.4548-06.2007
https://doi.org/10.1523/jneurosci.4548-06.2007
Autor:
Cristina M. Alberini, Panayiotis Tsokas, Ana Garcia-Osta, Robert D. Blitzer, Emmanuel M. Landau, Gabriella Pollonini
Publikováno v:
The Journal of Neuroscience. 26:7919-7932
Muscle-specific tyrosine kinase receptor (MuSK) has been believed to be mainly expressed and functional in muscle, in which it mediates the formation of neuromuscular junctions. Here we show that MuSK is expressed in the brain, particularly in neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad72b860af4b71a0853ccbaffaf176f
https://doi.org/10.1523/jneurosci.1674-06.2006
https://doi.org/10.1523/jneurosci.1674-06.2006
Autor:
Elizabeth A. Grace, Stuart C. Sealfon, Emmanuel M. Landau, Robert D. Blitzer, Tao Ma, Panayiotis Tsokas, Ravi Iyengar, Pokman Chan
Publikováno v:
Journal of Neuroscience. 25:5833-5843
The maintenance of long-term potentiation (LTP) requires a brief period of accelerated protein synthesis soon after synaptic stimulation, suggesting that an early phase of enhanced translation contributes to stable LTP. The mechanism regulating prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd588345ecced16bc530ab5a01acd787
https://doi.org/10.1523/jneurosci.0599-05.2005
https://doi.org/10.1523/jneurosci.0599-05.2005
Autor:
Robert D. Blitzer, Kichiemon Asoma, Panayiotis Tsokas, John H. Morrison, Emmanuel M. Landau, Ravi Iyengar, Maria Grazia Giovannini, Tony Wong
Publikováno v:
The Journal of Neuroscience. 21:7053-7062
Activation of mitogen-activated protein kinase (MAPK) and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) are required for numerous forms of neuronal plasticity, including long-term potentiation (LTP). We induced LTP in rat hippocampal area CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464a5d022d312074ef2493ca27710088
https://doi.org/10.1523/jneurosci.21-18-07053.2001
https://doi.org/10.1523/jneurosci.21-18-07053.2001
Autor:
Robert D. Blitzer, John H. Connor, George P. Brown, Shirish Shenolikar, Emmanuel M. Landau, Tony Wong, Ravi Iyengar
Publikováno v:
The Journal of Neuroscience. 20:7880-7887
Long-term potentiation (LTP) can be induced in the Schaffer collateral→CA1 synapse of hippocampus by stimulation in the θ frequency range (5–12 Hz), an effect that depends on activation of the cAMP pathway. We investigated the mechanisms of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3b4b0a3cca088a82039fac454e8c07
https://doi.org/10.1523/jneurosci.20-21-07880.2000
https://doi.org/10.1523/jneurosci.20-21-07880.2000
Publikováno v:
Cell. 103:193-200
One characteristic common to all organisms is the dynamic ability to coordinate constantly one's activities with environmental changes. The function of communicating with the environment is achieved through a number of pathways that receive and proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f46995c0246cad3713218d362788da
https://doi.org/10.1016/s0092-8674(00)00112-4
https://doi.org/10.1016/s0092-8674(00)00112-4
Autor:
Nikolaos K. Robakis, Maria Grazia Giovannini, Tony Wong, Menalas N Pangalos, Robert D. Blitzer, Emmanuel M. Landau
Publikováno v:
Molecular Brain Research. 76:115-120
Amyloid beta peptides (Abetas) of 39-43 amino acids constitute the major protein component of the amyloid plaques found in Alzheimer's disease brain. The generation of Abetas is regulated by the phosphoinositide (PI) pathway, which commonly couples t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf474c932e1ff7152da17295811c48bd
https://doi.org/10.1016/s0169-328x(99)00340-x
https://doi.org/10.1016/s0169-328x(99)00340-x
Publikováno v:
Neuron. 15(6):1403-1414
The role of the CAMP pathway in LTP was studied in the CAI region of hippocampus. Widely spaced trains of high frequency stimulation generated CAMP postsynaptically via NMDA receptors and calmodulin, consistent with the Ca 2+ /calmodulin-mediated sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e4f5cbcfc166cae45f98feb295726e
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(48)
The persistent or “late” phase of long-term potentiation (L-LTP), which requires protein synthesis, can be induced by relatively intense synaptic activity. The ability of such strong synaptic protocols to engage the translational machinery and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993891db26b61fc7135ae0a5920d1c3c
https://pubmed.ncbi.nlm.nih.gov/22131415
https://pubmed.ncbi.nlm.nih.gov/22131415
Autor:
E. C. Healy, Emmanuel M. Landau, Ravi Iyengar, Richard T. Premont, Hai-Wen Ma, Robert D. Blitzer
Publikováno v:
Journal of Biological Chemistry. 268:19915-19918
Xenopus oocytes exhibit a receptor-evoked Cl- current that is mediated through the activation of phospholipase C (PLC) and release of intracellular Ca2+. The identity of PLC(s) mediating this effect is unknown. We have cloned cDNAs encoding a new for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e44c9df1156cff4a522eabeaf312e596
https://doi.org/10.1016/s0021-9258(20)80671-1
https://doi.org/10.1016/s0021-9258(20)80671-1