Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Emmanuel L C de los Santos"'
Autor:
Chuan Huang, Daniel Zabala, Emmanuel L C de los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Publikováno v:
Nucleic Acids Research. 51:1488-1499
Advances in DNA sequencing technology and bioinformatics have revealed the enormous potential of microbes to produce structurally complex specialized metabolites with diverse uses in medicine and agriculture. However, these molecules typically requir
Autor:
Gustavo Perez Ortiz, John D. Sidda, Emmanuel L. C. de los Santos, Sarah M. Barry, Catherine B. Hubert
Publikováno v:
Chemical Communications (Cambridge, England)
The antimycobacterial peptides, rufomycins, have their antibiotic activity conferred by oxidative tailoring of the cyclic peptide. Here we elucidate the roles of cytochrome P450s RufS and RufM in regioselective epoxidation and alkyl oxidation respect
Autor:
Patrick Capel, Christophe Corre, Ming Toh, Kameshwari Chengan, Simon J. Moore, Seth Coode, Soo-Mei Chee, Emmanuel L. C. de los Santos, Hung-En Lai, Paul S. Freemont
Prokaryotic cell-free coupled transcription–translation (TX-TL) systems are emerging as a powerful tool to examine natural product biosynthetic pathways in a test tube. The key advantages of this approach are the reduced experimental time scales an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd21974a612b04d08ec501bd1eabebaf
http://wrap.warwick.ac.uk/147846/7/WRAP-Streptomyces-venezuelae-cell-free-toolkit-synthetic-biology-2021.pdf
http://wrap.warwick.ac.uk/147846/7/WRAP-Streptomyces-venezuelae-cell-free-toolkit-synthetic-biology-2021.pdf
Autor:
Simon J. Moore, Soo-Mei Chee, Patrick Capel, Emmanuel L. C. de los Santos, Ming Toh, Seth Coode, Paul S. Freemont, Christophe Corre, Hung-En Lai
Prokaryotic cell-free coupled transcription-translation (TX-TL) systems are emerging as a powerful tool to examine natural product biosynthetic pathways in a test-tube. The key advantages of this approach are the reduced experimental timescales and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e65c9504141fa1a2d3e4d69e0dfe0e03
https://doi.org/10.1101/2020.11.16.384693
https://doi.org/10.1101/2020.11.16.384693
Autor:
Paulina K. Sydor, Joleen Masschelein, Timothy R. Valentic, Daniel Griffiths, Vilmos Fülöp, Neil J. Oldham, Józef R. Lewandowski, Angelo Gallo, Emmanuel L. C. de los Santos, Shiou-Chuan Tsai, Gregory L. Challis, Matthew Jenner, Shanshan Zhou, Lucio Manzi, Simone Kosol, Dean Rea
Publikováno v:
Nature Chemistry, vol 11, iss 10
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PubMed Central
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Nature chemistry
Nature chemistry, vol 11, iss 10
Nature Chemistry
UnpayWall
ORCID
Microsoft Academic Graph
Datacite
CORE (RIOXX-UK Aggregator)
Lirias
Sygma
PubMed Central
CORE
Nature chemistry
Nature chemistry, vol 11, iss 10
Nature Chemistry
Modular polyketide synthases and non-ribosomal peptide synthetases are molecular assembly lines that consist of several multienzyme subunits that undergo dynamic self-assembly to form a functional megacomplex. N- and C-terminal docking domains are us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99745ffd52627eeaf7f2fc926a62df29
https://escholarship.org/uc/item/75m6f7xm
https://escholarship.org/uc/item/75m6f7xm
Autor:
Teofila O. Zulaybar, Daniel Zabala, Edwin P. Alcantara, Joleen Masschelein, Irene A. Papa, Emmanuel L. C. de los Santos, Aileen B. Custodio, Lijiang Song, Gregory L. Challis, Shanshan Zhou, Felaine A.M. Sumang
Pentamycin is a polyene antibiotic, registered in Switzerland for the treatment of vaginal candidiasis, trichomo-niasis and mixed infections. Chemical instability has hindered its wide-spread application and development as a drug. Here we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8413fd241800f1cd8949ea634b3e9f4
https://doi.org/10.1101/604736
https://doi.org/10.1101/604736
Publikováno v:
Access Microbiology. 1
The large amount of data from inexpensive sequencing means that the number of putative biosynthetic gene clusters (BGCs) far exceeds our ability to experimentally characterize them. This necessitates the need for development of further tools to analy
Autor:
Marnix H. Medema, Victòria Pascal Andreu, Emmanuel L. C. de los Santos, Francesco Del Carratore, Kai Blin, Tilmann Weber, Sang Yup Lee
Publikováno v:
Blin, K, Pascal Andreu, V, de Los Santos, E L C, Del Carratore, F, Lee, S Y, Medema, M H & Weber, T 2019, ' The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters ', Nucleic Acids Research, vol. 47, no. D1, pp. D625–D630 . https://doi.org/10.1093/nar/gky1060
Blin, K, Pascal Andreu, V, De Los Santos, E L C, Del Carratore, F, Lee, S Y, Medema, M H & Weber, T 2018, ' The antiSMASH database version 2: A comprehensive resource on secondary metabolite biosynthetic gene clusters ', Nucleic acids research, vol. 47, no. D1, pp. D625–D630 . https://doi.org/10.1093/nar/gky1060
Nucleic Acids Research
Nucleic acids research 47 (2019) D1
Nucleic acids research, 47(D1), D625-D630
Blin, K, Pascal Andreu, V, De Los Santos, E L C, Del Carratore, F, Lee, S Y, Medema, M H & Weber, T 2018, ' The antiSMASH database version 2: A comprehensive resource on secondary metabolite biosynthetic gene clusters ', Nucleic acids research, vol. 47, no. D1, pp. D625–D630 . https://doi.org/10.1093/nar/gky1060
Nucleic Acids Research
Nucleic acids research 47 (2019) D1
Nucleic acids research, 47(D1), D625-D630
Natural products originating from microorganisms are frequently used in antimicrobial and anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing availability of microbial genome data has made it possible to access t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9816752a01a0a379b15d77c0a0f16893
https://orbit.dtu.dk/en/publications/a380355d-e084-4d2a-8ecd-77e566f39620
https://orbit.dtu.dk/en/publications/a380355d-e084-4d2a-8ecd-77e566f39620
Autor:
Anthony W. Goering, Marley Yeong, Michael W. Mullowney, William W. Metcalf, Pablo Cruz-Morales, Regan J. Thomson, James H. Tryon, Arne Roeters, Neil L. Kelleher, Nelly Selem-Mojica, Satria A. Kautsar, Antonio Fernandez-Guerra, Emmanuel L. C. de los Santos, Wouter Lokhorst, Jorge C. Navarro-Muñoz, Elizabeth I. Parkinson, Marnix H. Medema, Sahar Abubucker, Francisco Barona-Gómez, Luciana Teresa Dias Cappelini
Publikováno v:
Nature chemical biology
Nature Chemical Biology, 16(1), 60-+. Nature Publishing Group
Nature Chemical Biology 16 (2019)
Nature Chemical Biology, 16, 60-68
Nature Chemical Biology, 16(1), 60-+. Nature Publishing Group
Nature Chemical Biology 16 (2019)
Nature Chemical Biology, 16, 60-68
Genome mining has become a key technology to exploit natural product diversity. Although initially performed on a single-genome basis, the process is now being scaled up to mine entire genera, strain collections and microbiomes. However, no bioinform
Autor:
James H. Tryon, Marley Yeong, Pablo Cruz-Morales, Neil L. Kelleher, Satria A. Kautsar, Luciana Teresa Dias Cappelini, Francisco Barona-Gómez, Michael W. Mullowney, William W. Metcalf, Arne Roeters, Jorge C. Navarro-Muñoz, Regan J. Thomson, Elizabeth I. Parkinson, Antonio Fernandez-Guerra, Emmanuel L. C. de los Santos, Wouter Lokhorst, Marnix H. Medema, Sahar Abubucker, Nelly Selem-Mojica
Genome mining has become a key technology to explore and exploit natural product diversity through the identification and analysis of biosynthetic gene clusters (BGCs). Initially, this was performed on a single-genome basis; currently, the process is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc5d283ce00ba3f61d8f7f3c5a3e8fb
https://doi.org/10.1101/445270
https://doi.org/10.1101/445270