Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Emmanuel Giudice"'
Autor:
Moise Mansour, Emmanuel Giudice, Xibing Xu, Hatice Akarsu, Patricia Bordes, Valérie Guillet, Donna-Joe Bigot, Nawel Slama, Gaetano D’urso, Sophie Chat, Peter Redder, Laurent Falquet, Lionel Mourey, Reynald Gillet, Pierre Genevaux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Toxin-antitoxin systems are widespread in bacteria. Here the authors present structures of M. tuberculosis HigBTAC alone and bound to the ribosome in the presence of native cspA mRNA, shedding light on its mechanism of translation inhibition.
Externí odkaz:
https://doaj.org/article/1ad0741fe184439087433a275dfe666e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Trans-translation, mediated by small protein B (SmpB) and transfer-messenger RNA (tmRNA), enables recycling of the ribosomes stalled on defective mRNAs in bacteria. Here, the authors report structures of the ribosome during trans-translation that rev
Externí odkaz:
https://doaj.org/article/3a1e36fd68b64f30af486fdffef9efd0
Autor:
Emmanuel Giudice, Sylvie Georgeault, Régis Lavigne, Charles Pineau, Annie Trautwetter, Gwennola Ermel, Carlos Blanco, Reynald Gillet
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3491 (2023)
Ribosome biogenesis is a complex and multistep process that depends on various assembly factors. To understand this process and identify the ribosome assembly intermediates, most studies have set out to delete or deplete these assembly factors. Inste
Externí odkaz:
https://doaj.org/article/a18ceead22864538bb2a54618911bbbd
Autor:
Rafael Gomes Von Borowski, Sophie Chat, Rafael Schneider, Sylvie Nonin-Lecomte, Serge Bouaziz, Emmanuel Giudice, Aline Rigon Zimmer, Simone Cristina Baggio Gnoatto, Alexandre José Macedo, Reynald Gillet
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Staphylococci are pathogenic biofilm-forming bacteria and a source of multidrug resistance and/or tolerance causing a broad spectrum of infections. These bacteria are enclosed in a matrix that allows them to colonize medical devices, such as
Externí odkaz:
https://doaj.org/article/465974453a2e458c9a809ec7acc91333
Autor:
Rodrigo Campos-Silva, Gaetano D’Urso, Olivier Delalande, Emmanuel Giudice, Alexandre José Macedo, Reynald Gillet
Publikováno v:
Microorganisms, Vol 10, Iss 1, p 3 (2021)
Because of the ever-increasing multidrug resistance in microorganisms, it is crucial that we find and develop new antibiotics, especially molecules with different targets and mechanisms of action than those of the antibiotics in use today. Translatio
Externí odkaz:
https://doaj.org/article/ac03e05c6a424080b9b21cef718cf52c
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23819 (2011)
Dystrophin is a large protein involved in the rare genetic disease Duchenne muscular dystrophy (DMD). It functions as a mechanical linker between the cytoskeleton and the sarcolemma, and is able to resist shear stresses during muscle activity. In all
Externí odkaz:
https://doaj.org/article/dc015f86c1f740da8707f3c41916764e
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2023, ⟨10.1093/nar/gkad126⟩
Nucleic Acids Research, 2023, ⟨10.1093/nar/gkad126⟩
The multidomain ribosomal protein bS1 is the biggest and the most flexible and dynamic protein in the 30S small subunit. Despite being essential for mRNA recruitment and its primary role in the accommodation of the start codon within the decoding cen
Insights into the ribosomal trans ‐translation rescue system: lessons from recent structural studies
Publikováno v:
FEBS Journal
FEBS Journal, 2022, ⟨10.1111/febs.16349⟩
FEBS Journal, 2022, ⟨10.1111/febs.16349⟩
International audience; The arrest of protein synthesis caused when ribosomes stall on an mRNA lacking a stop codon is a deadly risk for all cells. In bacteria, this situation is remedied by the trans-translation quality control system. Trans-transla
Publikováno v:
Nature Communications
Nature Communications, 2021, 12 (1), pp.4909. ⟨10.1038/s41467-021-24881-4⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4909. ⟨10.1038/s41467-021-24881-4⟩
Nature Communications, 2021, 12 (1), pp.4909. ⟨10.1038/s41467-021-24881-4⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4909. ⟨10.1038/s41467-021-24881-4⟩
In bacteria, trans-translation is the main rescue system, freeing ribosomes stalled on defective messenger RNAs. This mechanism is driven by small protein B (SmpB) and transfer-messenger RNA (tmRNA), a hybrid RNA known to have both a tRNA-like and an
Autor:
Reynald Gillet, Aline Rigon Zimmer, Alexandre José Macedo, Rafael Gomes Von Borowski, Simone Cristina Baggio Gnoatto, Sylvie Nonin-Lecomte, Emmanuel Giudice, Rafael de Oliveira Schneider, Sophie Chat, Serge Bouaziz
Staphylococci are pathogenic biofilm-forming bacteria, source of multidrug-resistance and/or – tolerance causing a broad spectrum of infections. These bacteria are enclosed in a matrix that allows them to colonize medical devices such as catheters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70c947ce0f67106ba8de60aeaac9432
https://doi.org/10.1101/2020.04.03.022020
https://doi.org/10.1101/2020.04.03.022020