The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation.

Autor: Emmanuel Gallaud, Laurent Richard-Parpaillon, Laetitia Bataillé, Aude Pascal, Mathieu Métivier, Vincent Archambault, Régis Giet

Publikováno v: PLoS Genetics, Vol 18, Iss 4, p e1010145 (2022)

The maintenance of a restricted pool of asymmetrically dividing stem cells is essential for tissue homeostasis. This process requires the control of mitotic progression that ensures the accurate chromosome segregation. In addition, this event is coup

Externí odkaz: https://doaj.org/article/9c5a51037ed44bd5852710ef4f3b144b

Aurora A Protein Kinase: To the Centrosome and Beyond

Autor: Laura Magnaghi-Jaulin, Grégory Eot-Houllier, Emmanuel Gallaud, Régis Giet

Publikováno v: Biomolecules, Vol 9, Iss 1, p 28 (2019)

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Num

Externí odkaz: https://doaj.org/article/1f723f1cd70e47a9a3c79205a0370f52

Peripheral microtubules ensure asymmetric furrow positioning in neural stem cells

Autor: Laurent Richard-Parpaillon, Alexandre Thomas, Matthew S. Savoian, Régis Giet, Emmanuel Gallaud, Laurence Serre, Isabelle Arnal, Aude Pascal

Neuroblast (NB) cell division is characterized by a basal positioning of the cleavage furrow resulting in a large difference in size between the future daughter cells. In animal cells, furrow placement and assembly is governed by centralspindlin, a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aff5ffc24343f213709cf5e018ae55
https://hal.archives-ouvertes.fr/hal-03100300

A novel benzodiazepine derivative that suppresses microtubule dynamics and impairs mitotic progression

Autor: Siou Ku, Mathieu Métivier, Emmanuel Gallaud, Vittoria Pirani, Alexandre Thomas, Denis Chrétien, Lorenzo Corsi, Christelle Benaud, Régis Giet, Roberta Ettari

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩
Journal of Cell Science, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩

International audience; A novel 2,3-benzodiazepine-4 derivative, named 1g, has recently been shown to function as an anti-proliferative compound. We now show that it perturbs the formation of a functional mitotic spindle, inducing a spindle assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0440ebddcc53d74dfe2ba665936dd3ba
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02543756

Drosophila Tubulin-Specific Chaperone E Recruits Tubulin around Chromatin to Promote Mitotic Spindle Assembly

Autor: Romain Gibeaux, Jean-Philippe Gagné, Laurent Richard-Parpaillon, Emmanuel Gallaud, Régis Giet, Mathieu Métivier, Christelle Benaud, Guy G. Poirier, Alexandre Thomas, Denis Chrétien, Aude Pascal

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2020, ⟨10.1016/j.cub.2020.11.009⟩
Current Biology-CB, Elsevier, 2021, 31 (4), pp.684-695.e6. ⟨10.1016/j.cub.2020.11.009⟩
Current Biology-CB, 2021, 31 (4), pp.684-695.e6. ⟨10.1016/j.cub.2020.11.009⟩

International audience; Proper assembly of mitotic spindles requires microtubule nucleation not only at the centrosomes but also around chromatin. In this study, we found that the Drosophila tubulin-specific chaperone dTBCE is required for the enrich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea72db98bb999c46a34233b4cea8da1
https://pubmed.ncbi.nlm.nih.gov/33259793