Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches

Autor: Jérôme Seguin, Emmanuel Favry, Isabelle Correia, Jean-Luc Pernodet, Sylvie Lautru, Jerzy Witwinowski, Laëtitia Caraty, Mireille Moutiez, Matthieu Coupet, Corinne Saulnier, Olivier Lequin, Muriel Gondry, Pascal Belin, Emmanuelle Darbon, Antonio C. Ruzzini

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.20226. ⟨10.1038/s41598-019-56747-7⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-56747-7⟩
Scientific Reports, 2019, 9 (1), pp.20226. ⟨10.1038/s41598-019-56747-7⟩

The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737ea58699d6e1abfd1d6af06e9a0677
https://hal.archives-ouvertes.fr/hal-02431235/document

The Tumor Antigen Cyclin B1 Hosts Multiple CD4 T Cell Epitopes Differently Recognized by Pre-Existing Naive and Memory Cells in Both Healthy and Cancer Donors

Autor: Anne-Sophie Bats, Claire Chevaleyre, Hervé Nozach, Anais Mhoumadi, Florence Castelli, Elodie Marcon, Françoise Le Pimpec-Barthes, Elizabeth Fabre, Guillaume Cosler, Bernard Maillere, Stéphane Oudard, Stéphane Hans, Emmanuel Favry, Eric Tartour, Emeline Vinatier, Nadine Benhamouda

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 195 (4), pp.1891-1901. ⟨10.4049/jimmunol.1402548⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015
The Journal of Immunology
The Journal of Immunology, 2015
Journal of Immunology, 2015, 195 (4), pp.1891-1901. ⟨10.4049/jimmunol.1402548⟩

Cyclin B1 (CCNB1) is considered as a potential target for a cancer vaccine, as it is overexpressed in many malignant cells, while being transiently expressed in normal cells. To evaluate the CD4 T cell response to CCNB1, we derived T cell lines by mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba0d03df95315ec9fc78be288e82171
https://doi.org/10.4049/jimmunol.1402548

Human CD4 T cell epitopes selective for Vaccinia versus Variola virus

Autor: Bernard Maillere, Alicia Probst, Aurore Besse, Valérie Tanchou, Gilles Imbert, Emmanuel Favry, Florence Castelli

Publikováno v: Molecular Immunology. 53:453-459

Due to the high degree of sequence identity between Orthopoxvirus species, the specific B and T cell responses raised against these viruses are largely cross-reactive and poorly selective. We therefore searched for CD4 T cell epitopes present in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d73e2c840d885eb7ebecf194efb0ed
https://doi.org/10.1016/j.molimm.2012.10.011

An Arthritis-Suppressive and Treg Cell-Inducing CD4+ T Cell Epitope Is Functional in the Context of HLA-Restricted T Cell Responses

Autor: Charlotte, de Wolf, Ruurd, van der Zee, Ineke, den Braber, Tibor, Glant, Bernard, Maillère, Emmanuel, Favry, Menno, van Lummel, Frits, Koning, Aad, Hoek, Irene, Ludwig, Willem, van Eden, Femke, Broere

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 68(3)

We previously showed that mycobacterial Hsp70-derived peptide B29 induced B29-specific Treg cells that suppressed experimental arthritis in mice via cross-recognition of their mammalian Hsp70 homologs. The aim of the current study was to characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d83d3e73575b07dee5557799c9bbca76
https://pubmed.ncbi.nlm.nih.gov/26414917

Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases

Autor: Jérôme Seguin, Emmanuel Favry, Robert Thai, Muriel Gondry, Mireille Moutiez, Pascal Belin, Emmanuelle Schmitt, Yves Mechulam

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2014, 5 (October), pp.5141. ⟨10.1038/ncomms6141⟩
Nature Communications, 2014, 5 (October), pp.5141. ⟨10.1038/ncomms6141⟩

International audience; Cyclodipeptide synthases form cyclodipeptides from two aminoacyl transfer RNAs. They use a ping-pong mechanism that begins with transfer of the aminoacyl moiety of the first aminoacyl tRNA onto a conserved serine, yielding an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3635e509227bcb2f33b594d822042a1
https://pubmed.ncbi.nlm.nih.gov/25284085