Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Emmanuel Donnadieu"'
Autor:
Luca Simula, Mattia Fumagalli, Lene Vimeux, Irena Rajnpreht, Philippe Icard, Gary Birsen, Dongjie An, Frédéric Pendino, Adrien Rouault, Nadège Bercovici, Diane Damotte, Audrey Lupo-Mansuet, Marco Alifano, Marie-Clotilde Alves-Guerra, Emmanuel Donnadieu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract The ability of CD8+ T cells to infiltrate solid tumors and reach cancer cells is associated with improved patient survival and responses to immunotherapy. Thus, identifying the factors controlling T cell migration in tumors is critical, so t
Externí odkaz:
https://doaj.org/article/643fa17256824db689f9eb5d26b03503
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103102- (2024)
Summary: Studying cell behavior in live human tumors is crucial to understand and improve response to immunotherapies. Here, we present a protocol to slice human ovarian tumors ex vivo, maintain their viability for 24 h, and monitor the behavior of C
Externí odkaz:
https://doaj.org/article/2e2f2db53520410e94a0965c3780bbed
Autor:
Kübra Yadigaroglu, Sonja Scharf, Steffen Gretser, Hendrik Schäfer, Aresu Sadeghi Shoreh Deli, Andreas G. Loth, Hasmik Yegoryan, Roland Schmitz, Emmanuel Donnadieu, Martin-Leo Hansmann, Sylvia Hartmann
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Although checkpoint molecules like CTLA-4 and PD1 have been described several years ago, checkpoint inhibitors such as Nivolumab (an anti-PD-1 antibody) have only recently been used to treat classic Hodgkin lymphoma (cHL). Several studies have shown
Externí odkaz:
https://doaj.org/article/e7b395a42a3144f3ac4f618244d7be03
Autor:
Nadia Mensali, Hakan Köksal, Sandy Joaquina, Patrik Wernhoff, Nicholas P. Casey, Paola Romecin, Carla Panisello, René Rodriguez, Lene Vimeux, Asta Juzeniene, Marit R. Myhre, Anne Fåne, Carolina Castilla Ramírez, Solrun Melkorka Maggadottir, Adil Doganay Duru, Anna-Maria Georgoudaki, Iwona Grad, Andrés Daniel Maturana, Gustav Gaudernack, Gunnar Kvalheim, Angel M. Carcaboso, Enrique de Alava, Emmanuel Donnadieu, Øyvind S. Bruland, Pablo Menendez, Else Marit Inderberg, Sébastien Wälchli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and
Externí odkaz:
https://doaj.org/article/aeb35d7698f54300a9d32846913690b0
Autor:
Florian Laforêts, Panoraia Kotantaki, Beatrice Malacrida, Samar Elorbany, Ranjit Manchanda, Emmanuel Donnadieu, Frances Balkwill
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106514- (2023)
Summary: Studies of the high-grade serous ovarian cancer (HGSOC) tumor microenvironment, the most lethal gynecological cancer, aim to enhance the efficiency of established therapies. Cell motility is an important process of anti-tumor response. Using
Externí odkaz:
https://doaj.org/article/4d987d96496c49cc950f690163d0635b
Autor:
Constanza Savid-Frontera, Maria Estefania Viano, Natalia S. Baez, Nicolas L. Lidon, Quentin Fontaine, Howard A. Young, Lene Vimeux, Emmanuel Donnadieu, Maria Cecilia Rodriguez-Galan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Virtual memory CD8+ T cells (TVM) have been described as cells with a memory-like phenotype but without previous antigen (Ag) exposure. TVM cells have the ability to respond better to innate stimuli rather than by TCR engagement, producing large amou
Externí odkaz:
https://doaj.org/article/b990de8c34a343ab96a05a6a2e3f4982
Autor:
David Espie, Emmanuel Donnadieu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adoptive transfer of T cells genetically engineered to express chimeric antigen receptors (CAR) has demonstrated striking efficacy for the treatment of several hematological malignancies, including B-cell lymphoma, leukemia, and multiple myeloma. How
Externí odkaz:
https://doaj.org/article/0dbfbf41d4884d7f91f66b2484cf93cd
Autor:
Katrin Merk-Ahmad, Julia Bein, Sonja Scharf, Hendrik Schäfer, Tobias Bexte, Evelyn Ullrich, Andreas G. Loth, Nadine Flinner, Tina Senff, Olga Schneider, Martin-Leo Hansmann, Matthieu Piel, Björn Häupl, Thomas Oellerich, Emmanuel Donnadieu, Sylvia Hartmann
Publikováno v:
Cancers, Vol 15, Iss 12, p 3226 (2023)
Nodal T-follicular helper cell lymphoma, angioimmunoblastic-type (AITL), is characterized by constitutional symptoms, advanced-stage disease, and generalized lymphadenopathy. A genetic hallmark of this lymphoma is the frequent occurrence of the RHOA
Externí odkaz:
https://doaj.org/article/03801afee4cf443d958d60d93b9f1865
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/89d2ee7e7c8e41eea12a8860cb794079
Autor:
Alba Nicolas-Boluda, Javier Vaquero, Lene Vimeux, Thomas Guilbert, Sarah Barrin, Chahrazade Kantari-Mimoun, Matteo Ponzo, Gilles Renault, Piotr Deptula, Katarzyna Pogoda, Robert Bucki, Ilaria Cascone, José Courty, Laura Fouassier, Florence Gazeau, Emmanuel Donnadieu
Publikováno v:
eLife, Vol 10 (2021)
Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing five preclinical mouse tumor models with heterogeneous tumor mic
Externí odkaz:
https://doaj.org/article/fcd6d60f522e467b954160f81e927d69