Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Emmanuel Deval"'
Autor:
Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1010993 (2023)
Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity mechanisms that can lead to chronic pain states. Windup is a well-known spinal pain facilitation process initially described several dec
Externí odkaz:
https://doaj.org/article/8145c22d0aba4767bbe0cc391ea7fa9b
Autor:
Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related ion channels, including Acid-Sensing Ion Channel 3 (ASIC3), a cationic channel mainly expressed in peri
Externí odkaz:
https://doaj.org/article/b32653ae1ec44d44b20eb133327cc45a
Autor:
Marta Prieto, Alessandra Folci, Gwénola Poupon, Sara Schiavi, Valeria Buzzelli, Marie Pronot, Urielle François, Paula Pousinha, Norma Lattuada, Sophie Abelanet, Sara Castagnola, Magda Chafai, Anouar Khayachi, Carole Gwizdek, Frédéric Brau, Emmanuel Deval, Maura Francolini, Barbara Bardoni, Yann Humeau, Viviana Trezza, Stéphane Martin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The R138Q mutation in the Fragile X Mental Retardation 1 (FMR1) gene has been associated with Fragile X syndrome (FXS). Here, the authors present a Fmr1 R138Q Knock-In mouse model and show that R138Q mutation results in impaired long-term potentiatio
Externí odkaz:
https://doaj.org/article/1f547051b6104cb2ae2a8dd5047148af
Autor:
Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S. Ahmed, Camilla I. Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 342 (2023)
Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion channels (ASIC3). The aim of the present study was to investigate the lipid contents of the synovial f
Externí odkaz:
https://doaj.org/article/b61eab18d385442b91656b854ae7850b
Publikováno v:
Toxins, Vol 14, Iss 10, p 709 (2022)
Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form
Externí odkaz:
https://doaj.org/article/28d5b725432d4217843875ac864d4139
Autor:
Anouar Khayachi, Carole Gwizdek, Gwénola Poupon, Damien Alcor, Magda Chafai, Frédéric Cassé, Thomas Maurin, Marta Prieto, Alessandra Folci, Fabienne De Graeve, Sara Castagnola, Romain Gautier, Lenka Schorova, Céline Loriol, Marie Pronot, Florence Besse, Frédéric Brau, Emmanuel Deval, Barbara Bardoni, Stéphane Martin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density
Externí odkaz:
https://doaj.org/article/57e3d66daa9b4a92b4183ee79455e739
Autor:
Christelle Devader, Sébastien Moreno, Morgane Roulot, Emmanuel Deval, Thomas Dix, Carlos Morales, Jean Mazella
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three different receptors (NTSR1, NTSR2 and NTSR3 also called sortilin). Pharmacological approaches and generation of NTSR1 and NTSR2-deficient mice allowed to determi
Externí odkaz:
https://doaj.org/article/d17e471164d242c1bd5d5845efd5cd6b
Autor:
Jean Mazella, Olivier Pétrault, Guillaume Lucas, Emmanuel Deval, Sophie Béraud-Dufour, Carine Gandin, Malika El-Yacoubi, Catherine Widmann, Alice Guyon, Eric Chevet, Said Taouji, Grégory Conductier, Alain Corinus, Thierry Coppola, Gabriella Gobbi, Jean-Louis Nahon, Catherine Heurteaux, Marc Borsotto
Publikováno v:
PLoS Biology, Vol 8, Iss 4, p e1000355 (2010)
Current antidepressant treatments are inadequate for many individuals, and when they are effective, they require several weeks of administration before a therapeutic effect can be observed. Improving the treatment of depression is challenging. Recent
Externí odkaz:
https://doaj.org/article/1ce8e5d7cde54153ac1956b5d289c1e1
Autor:
Florian Jacquot, Spiro Khoury, Bonnie Labrum, Kévin Delanoe, Ludivine Pidoux, Julie Barbier, Lauriane Delay, Agathe Bayle, Youssef Aissouni, David A. Barriere, Kim Kultima, Eva Freyhult, Anders Hugo, Eva Kosek, Aisha S. Ahmed, Alexandra Jurczak, Eric Lingueglia, Camilla I. Svensson, Véronique Breuil, Thierry Ferreira, Fabien Marchand, Emmanuel Deval
Rheumatic diseases are often associated to debilitating chronic pain, which remains difficult to treat and requires new therapeutic strategies. We had previously identified lysophosphatidylcholine (LPC) in the synovial fluids from few patients and sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e966e18b77be579561f2bcdde88ca135
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464463
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464463
Lysophosphatidyl-choline (LPC), a member of the phospholipid family, has recently emerged as an interesting new player in pain. It has been proposed to mediate pain through Acid-Sensing Ion Channel 3 (ASIC3), a pain-related channel mainly expressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d598eaebb676a2f500524129999bce6e
https://hal.archives-ouvertes.fr/hal-03119949/file/2020.12.28.424561v1.full.pdf
https://hal.archives-ouvertes.fr/hal-03119949/file/2020.12.28.424561v1.full.pdf