Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Emmanuel D Levy"'
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 549-572 (2024)
Abstract Biological systems can gain complexity over time. While some of these transitions are likely driven by natural selection, the extent to which they occur without providing an adaptive benefit is unknown. At the molecular level, one example is
Externí odkaz:
https://doaj.org/article/cf3efa538f3640cd8737509487af3cf2
Autor:
Sivan Kaminski Strauss, Dvir Schirman, Ghil Jona, Aaron N Brooks, Aditya M Kunjapur, Alex N Nguyen Ba, Alice Flint, Andras Solt, Andreas Mershin, Atray Dixit, Avihu H Yona, Bálint Csörgő, Bede Phillip Busby, Bianca P Hennig, Csaba Pál, Daniel Schraivogel, Daniel Schultz, David G Wernick, Deepa Agashe, Dikla Levi, Dmitry Zabezhinsky, Dor Russ, Ehud Sass, Einat Tamar, Elad Herz, Emmanuel D Levy, George M Church, Idan Yelin, Iftach Nachman, Jeffrey E Gerst, Joseph M Georgeson, Katarzyna P Adamala, Lars M Steinmetz, Marc Rübsam, Markus Ralser, Michael Klutstein, Michael M Desai, Nilima Walunjkar, Ning Yin, Noa Aharon Hefetz, Noah Jakimo, Olga Snitser, Omri Adini, Prashant Kumar, Rachel Soo Hoo Smith, Razi Zeidan, Ronen Hazan, Roni Rak, Roy Kishony, Shannon Johnson, Shira Nouriel, Sibylle C Vonesch, Simmie Foster, Tal Dagan, Tanita Wein, Thrasyvoulos Karydis, Timothy M Wannier, Timothy Stiles, Viridiana Olin-Sandoval, William F Mueller, Yinon M Bar-On, Orna Dahan, Yitzhak Pilpel
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000182 (2019)
In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Sho
Externí odkaz:
https://doaj.org/article/bb9a50be8dcc4dc98274ddfdc59bba88
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 4, p e1005499 (2017)
High-throughput in vitro methods have been extensively applied to identify linear information that encodes peptide recognition. However, these methods are limited in number of peptides, sequence variation, and length of peptides that can be explored,
Externí odkaz:
https://doaj.org/article/f069239de1e74aea870dd917bd4b415f
Autor:
Jonathan Boulais, Matthias Trost, Christian R Landry, Régis Dieckmann, Emmanuel D Levy, Thierry Soldati, Stephen W Michnick, Pierre Thibault, Michel Desjardins
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-14 (2010)
Abstract Amoeba use phagocytosis to internalize bacteria as a source of nutrients, whereas multicellular organisms utilize this process as a defense mechanism to kill microbes and, in vertebrates, initiate a sustained immune response. By using a larg
Externí odkaz:
https://doaj.org/article/dedc093817f64871a4e156e6ef64cae3
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106081 (2014)
Linear motifs mediate a wide variety of cellular functions, which makes their characterization in protein sequences crucial to understanding cellular systems. However, the short length and degenerate nature of linear motifs make their discovery a dif
Externí odkaz:
https://doaj.org/article/f9dcea9b44a045a8bb59c55c7a837c12
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 11, p e155 (2006)
Most of the proteins in a cell assemble into complexes to carry out their function. It is therefore crucial to understand the physicochemical properties as well as the evolution of interactions between proteins. The Protein Data Bank represents an im
Externí odkaz:
https://doaj.org/article/18be1bba4f3042f8a5063e5473806f9e
Publikováno v:
Physical Review Letters. 129
Biomolecular self-assembly spatially segregates proteins with a limited number of binding sites (valence) into condensates that coexist with a dilute phase. We develop a many-body lattice model for a three-component system of proteins with fixed vale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c28017fba337c0be6d6a5a78b10def
https://doi.org/10.1103/physrevlett.129.128102
https://doi.org/10.1103/physrevlett.129.128102
Autor:
José A. Villegas, Emmanuel D. Levy
Publikováno v:
Protein Science. 31
Membraneless organelles are cellular compartments that form by liquid-liquid phase separation of one or more components. Other molecules, such as proteins and nucleic acids, will distribute between the cytoplasm and the liquid compartment in accordan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4dfdf2404cc5ef216db3be656fe462
https://doi.org/10.1002/pro.4361
https://doi.org/10.1002/pro.4361
Publikováno v:
Current opinion in geneticsdevelopment. 76
Oligomeric proteins are central to cellular life and the duplication and divergence of their genes is a key driver of evolutionary innovations. The duplication of a gene coding for an oligomeric protein has numerous possible outcomes, which motivates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e0f3bc329d9fb180636612129d7c82
https://pubmed.ncbi.nlm.nih.gov/36007298
https://pubmed.ncbi.nlm.nih.gov/36007298
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1333-1340 (2014)
A single yeast cell contains a hundred million protein molecules. How these proteins are organized to orchestrate living processes is a central question in biology. To probe this organization in vivo, we measured the local concentration of proteins b
Externí odkaz:
https://doaj.org/article/82e503d062024d208a30278ff486a22b