Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Emmanuel Compe"'
Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability
Autor:
Pietro Berico, Maguelone Nogaret, Max Cigrang, Antonin Lallement, Fatemeh Vand-Rajabpour, Amanda Flores-Yanke, Giovanni Gambi, Guillaume Davidson, Leane Seno, Julian Obid, Bujamin H. Vokshi, Stephanie Le Gras, Gabrielle Mengus, Tao Ye, Carlos Fernandez Cordero, Mélanie Dalmasso, Emmanuel Compe, Corine Bertolotto, Eva Hernando, Irwin Davidson, Frédéric Coin
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113363- (2023)
Summary: Super-enhancers (SEs) are stretches of enhancers ensuring a high level of expression of key genes associated with cell function. The identification of cancer-specific SE-driven genes is a powerful means for the development of innovative ther
Externí odkaz:
https://doaj.org/article/58335d9b08f0478abe6c128c3b2392cd
Autor:
Jérémy Sandoz, Max Cigrang, Amélie Zachayus, Philippe Catez, Lise-Marie Donnio, Clèmence Elly, Jadwiga Nieminuszczy, Pietro Berico, Cathy Braun, Sergey Alekseev, Jean-Marc Egly, Wojciech Niedzwiedz, Giuseppina Giglia-Mari, Emmanuel Compe, Frédéric Coin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here the authors show that the exonuclease EXD2 is involved in the recovery of class II gene transcription after UV irradiation. EXD2 travels from the mitochondria to the nucleus to interact with RNA Pol II and degrade new synthetized mRNA to allow t
Externí odkaz:
https://doaj.org/article/a0d3f932123e4cc6bc846c308c77597d
Autor:
Federico Costanzo, Marta Martínez Diez, Gema Santamaría Nuñez, Juan Ignacio Díaz‐Hernandéz, Carlos Mario Genes Robles, Javier Díez Pérez, Emmanuel Compe, Romeo Ricci, Tsai‐Kun Li, Frédéric Coin, Juan Fernando Martínez Leal, Eva Maria Garrido‐Martin, Jean Marc Egly
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-17 (2022)
Abstract Small‐Cell Lung Cancer (SCLC) is an aggressive neuroendocrine malignancy with a poor prognosis. Here, we focus on the neuroendocrine SCLC subtypes, SCLC‐A and SCLC‐N, whose transcription addiction was driven by ASCL1 and NEUROD1 transc
Externí odkaz:
https://doaj.org/article/cd88b5d15b2b44f491249b78d9806cca
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The general transcription factors TFIIE and TFIIH assemble at the transcription start site with RNA Polymerase II. Here the authors provide evidence that the TFIIEα and TFIIEβ subunits anchor the TFIIH kinase module within the preinitiation complex
Externí odkaz:
https://doaj.org/article/121d77056e3d4d43a399accbfabcc5df
Autor:
Evanthia Pangou, Olga Bielska, Lucile Guerber, Stephane Schmucker, Arantxa Agote-Arán, Taozhi Ye, Yongrong Liao, Marta Puig-Gamez, Erwan Grandgirard, Charlotte Kleiss, Yansheng Liu, Emmanuel Compe, Zhirong Zhang, Ruedi Aebersold, Romeo Ricci, Izabela Sumara
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109129- (2021)
Summary: Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progres
Externí odkaz:
https://doaj.org/article/9113390d87134a99b61122d57b25a17d
Autor:
Olga Kolesnikova, Amélie Zachayus, Simon Pichard, Judit Osz, Natacha Rochel, Paola Rossolillo, Isabelle Kolb-Cheynel, Nathalie Troffer-Charlier, Emmanuel Compe, Olivier Bensaude, Imre Berger, Arnaud Poterszman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/e4e780ce6fc740d984f61a55ea5b32a1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Figure S2. Lurbinectedin inhibits RNA synthesis and promotes Pol II degradation in different cancer cell lines. (A) Kinetics of RNA synthesis. Ewing sarcoma (A673), colon (HCT-116), cervix (HeLa) and breast (MDA-MB-231) cancer cells were treated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8da166862674f25a646031cf11cb5c
https://doi.org/10.1158/1535-7163.22503247.v1
https://doi.org/10.1158/1535-7163.22503247.v1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Figure S3. NER machinery remains active in the presence of DRB. A dual incision assay (48) was performed by the co-incubation of NER (XPC, TFIIH, XPA, RPA, XPG and XPF) components with increasing amount of DRB (10, 20, 50 and 100µM).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cc5d82fce0c707d47533e216684b39
https://doi.org/10.1158/1535-7163.22503244.v1
https://doi.org/10.1158/1535-7163.22503244.v1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2b4d67b3fe474b639919f464e67012
https://doi.org/10.1158/1535-7163.22503232.v1
https://doi.org/10.1158/1535-7163.22503232.v1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Figure S4. Proposed mechanism of action of lurbinectedin Upon administration to cancer cells, (I) lurbinectedin targets GC rich regions; (II) Pol II starts the elongation phase of transcription of activated genes after being sequentially phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd2f8e2b0670ef4b22d3a908819c18f
https://doi.org/10.1158/1535-7163.22503241.v1
https://doi.org/10.1158/1535-7163.22503241.v1