Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Emmanuel Brouillet"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Huntington’s disease is an inherited disorder characterized by psychiatric, cognitive, and motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal phase precedes the onset, lasting decades. Current biomarkers include
Externí odkaz:
https://doaj.org/article/58f45c2b56ae4279a7aab55ce01f7769
Autor:
Jean-Baptiste Pérot, Anna Niewiadomska-Cimicka, Emmanuel Brouillet, Yvon Trottier, Julien Flament
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/06d375aa85d2492a84114e10af070394
Autor:
Charlotte Duwat, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, Caroline Jan, Pauline Gipchtein, Julien Mitja, Stéphane Fouquet, Marie-Laure Niepon, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Karine Cambon, Alexis-Pierre Bemelmans
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106116- (2023)
Tauopathy is a typical feature of Alzheimer's disease of major importance because it strongly correlates with the severity of cognitive deficits experienced by patients. During the pathology, it follows a characteristic spatiotemporal course which ta
Externí odkaz:
https://doaj.org/article/6df829acc824451a93ba913807abbb2e
Autor:
Lucile Mégret, Cloé Mendoza, Maialen Arrieta Lobo, Emmanuel Brouillet, Thi-Thanh-Yen Nguyen, Olivier Bouaziz, Antoine Chambaz, Christian Néri
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Micro-RNAs (miRNAs) are short (∼21 nt) non-coding RNAs that regulate gene expression through the degradation or translational repression of mRNAs. Accumulating evidence points to a role of miRNA regulation in the pathogenesis of a wide range of neu
Externí odkaz:
https://doaj.org/article/48b3f5790cc3413da2eb116f53568786
Autor:
Ana Lúcia Rebelo, Francesco Gubinelli, Pauline Roost, Caroline Jan, Emmanuel Brouillet, Nadja Van Camp, Richard R. Drake, Radka Saldova, Abhay Pandit
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background Neuroinflammation is an underlying pathology of all neurological conditions, the understanding of which is still being comprehended. A specific molecular pathway that has been overlooked in neuroinflammation is glycosylation (i.e.
Externí odkaz:
https://doaj.org/article/75a88742339b45babd60175335bcb9d7
Autor:
Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelmans
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105398- (2021)
The role played by microglia has taken the center of the stage in the etiology of Alzheimer's disease (AD). Several genome-wide association studies carried out on large cohorts of patients have indeed revealed a large number of genetic susceptibility
Externí odkaz:
https://doaj.org/article/8c8f6bf7190346289dcd6493fc8784a1
Autor:
Kalina Wiatr, Łukasz Marczak, Jean-Baptiste Pérot, Emmanuel Brouillet, Julien Flament, Maciej Figiel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Spinocerebellar ataxia type 3 (SCA3/MJD) is caused by CAG expansion mutation resulting in a long polyQ domain in mutant ataxin-3. The mutant protein is a special type of protease, deubiquitinase, which may indicate its prominent impact on the regulat
Externí odkaz:
https://doaj.org/article/7a4c91f909c24f0e9962e82f252ab731
Autor:
Charlotte Gary, Suzanne Lam, Anne-Sophie Hérard, James E. Koch, Fanny Petit, Pauline Gipchtein, Stephen J. Sawiak, Raphaëlle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, French Neuropathology Network, Emmanuel Brouillet, Luc Buée, Emmanuel E. Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenain
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-21 (2019)
Abstract Alzheimer’s disease is characterized by cognitive alterations, cerebral atrophy and neuropathological lesions including neuronal loss, accumulation of misfolded and aggregated β-amyloid peptides (Aβ) and tau proteins. Iatrogenic inductio
Externí odkaz:
https://doaj.org/article/e39ef7713ddd47a9b3847bf54d779c5c
Autor:
Kelly Ceyzériat, Lucile Ben Haim, Audrey Denizot, Dylan Pommier, Marco Matos, Océane Guillemaud, Marie-Ange Palomares, Laurene Abjean, Fanny Petit, Pauline Gipchtein, Marie-Claude Gaillard, Martine Guillermier, Sueva Bernier, Mylène Gaudin, Gwenaëlle Aurégan, Charlène Joséphine, Nathalie Déchamps, Julien Veran, Valentin Langlais, Karine Cambon, Alexis P Bemelmans, Jan Baijer, Gilles Bonvento, Marc Dhenain, Jean-François Deleuze, Stéphane H R Oliet, Emmanuel Brouillet, Philippe Hantraye, Maria-Angeles Carrillo-de Sauvage, Robert Olaso, Aude Panatier, Carole Escartin
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-23 (2018)
Abstract Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer’s disease. However, the specific role of reactive astrocytes is still debated. This controversy may stem from the fact that most stra
Externí odkaz:
https://doaj.org/article/5dde870f4e784d2e9f9227fff940a15d
Autor:
Rachel Kelly, Alexis-Pierre Bemelmans, Charlène Joséphine, Emmanuel Brouillet, Declan P. McKernan, Eilís Dowd
Publikováno v:
Molecules, Vol 27, Iss 2, p 507 (2022)
Since the discovery of α-synuclein as the major component in Lewy bodies, research into this protein in the context of Parkinson’s disease pathology has been exponential. Cannabinoids are being investigated as potential therapies for Parkinson’s
Externí odkaz:
https://doaj.org/article/34cd1aa5c0a6490e97b46759ce7c1d82