A theoretical analysis on the impact of relationship marketing practices on customer retention: A case of transformed small grocery retail shops in Mangaung Municipality area in South Africa

Autor: Emmanuel Ikechukwu Iwuchukwu, Edmund Owusu Amoakoh, Crispen Chipunza

Publikováno v: African Journal of Hospitality, Tourism and Leisure, Vol 8, Iss special edition (2019)

Given the fact that South Africa is one of the global emerging markets, many of the emerging small businesses are transiting from informal to formal businesses. The importance and contribution of these ventures in economic growth and job creation can

Externí odkaz: https://doaj.org/article/4fff3938324c47c5aea94f868cd97d17

Effect of Divalent Metal Ion on the Structure, Stability and Function of Klebsiella pneumoniae Nicotinate-Nucleotide Adenylyltransferase: Empirical and Computational Studies

Autor: Olamide Jeje, Reabetswe Maake, Ruan van Deventer, Veruschka Esau, Emmanuel Amarachi Iwuchukwu, Vanessa Meyer, Thandeka Khoza, Ikechukwu Achilonu

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 116
International Journal of Molecular Sciences, Vol 23, Iss 116, p 116 (2022)

The continuous threat of drug-resistant Klebsiella pneumoniae justifies identifying novel targets and developing effective antibacterial agents. A potential target is nicotinate nucleotide adenylyltransferase (NNAT), an indispensable enzyme in the bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab974156b5f5a09a1def0a8802cd535b

A probable means to an end: exploring P131 pharmacophoric scaffold to identify potential inhibitors of Cryptosporidium parvum inosine monophosphate dehydrogenase

Autor: Kehinde F, Omolabi, Emmanuel A, Iwuchukwu, Clement, Agoni, Fisayo A, Olotu, Mahmoud E S, Soliman

Publikováno v: Journal of molecular modeling. 27(2)

Compound P131 has been established to inhibit Cryptosporidium parvum's inosine monophosphate dehydrogenase (CpIMPDH). Its inhibitory activity supersedes that of paromomycin, which is extensively used in treating cryptosporidiosis. Through the per-res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::552fcb8c0b22914454618c335b52405c
https://pubmed.ncbi.nlm.nih.gov/33423140

Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2-P3 α-ketoamide derivative and Pentagastrin: an in-silico drug discovery approach

Autor: Ikechukwu Achilonu, Emmanuel Amarachi Iwuchukwu, Okechinyere Juliet Achilonu, Manuel Antonio Fernandes

The SARS-CoV-2 main protease (Mpro) is an attractive target towards discovery of drugs to treat COVID-19 because of its key role in virus replication. The atomic structure of Mpro in complex with an α-ketoamide inhibitor (Lig13b) is available (PDB I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30b5d1f2e2de9f334090681c42ef72c9
https://doi.org/10.21203/rs.3.rs-30382/v1

An empirical and theoretical description of Schistosoma japonicum glutathione transferase inhibition by bromosulfophthalein and indanyloxyacetic acid 94

Autor: Ikechukwu Achilonu, Roland Worth, Heini W. Dirr, Emmanuel Amarachi Iwuchukwu, Kagiso Pooe

Publikováno v: Journal of Molecular Structure. 1223:128892

The inhibition of the 26-kDa glutathione transferase from Schistosoma japonicum (Sj26GST) by bromosulfophthalein (BSP) and indanaloxyacetic acid-94 (IAA-94) was investigated using a systematic combination of empirical and theoretical approaches. Acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcedf0f9313575cf8a5104e3122acc1e
https://doi.org/10.1016/j.molstruc.2020.128892