Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Emmanuel, Gustin"'
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 111-117 (2023)
Recent advances in automated microscopy and image analysis enables quantitative profiling of cellular phenotypes (Cell Painting). It paves the way for studying the broad effects of chemical perturbations on biological systems at large scale during le
Externí odkaz:
https://doaj.org/article/3b1c372133df40018f77f62c05eb9ec2
Autor:
Michaël Barbier, Steffen Jaensch, Frans Cornelissen, Suzana Vidic, Kjersti Gjerde, Ronald de Hoogt, Ralph Graeser, Emmanuel Gustin, Yolanda T Chong, IMI PREDECT Consortium
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156942 (2016)
In oncology, two-dimensional in-vitro culture models are the standard test beds for the discovery and development of cancer treatments, but in the last decades, evidence emerged that such models have low predictive value for clinical efficacy. Theref
Externí odkaz:
https://doaj.org/article/d6adf23124fc40dca32e5c00a44812b3
Autor:
Virginie Uhlmann, Jason R. Swedlow, David Grunwald, Ugis Sarkans, Peijun Zhang, Helen R. Saibil, Andrew W. Nicholls, Shuichi Onami, Cesare Catavitello, Ewan Birney, Jim Swoger, Jean-Karim Hériché, Perrine Paul-Gilloteaux, Frances Wong, Christopher Cawthorne, Maddy Parsons, Kedar Narayan, Josh Moore, Wah Chiu, Stephan Wagner-Conrad, Terry Meehan, Gerard J. Kleywegt, Michele C. Darrow, Gabriel G. Martins, Pasi Kankaanpää, Ardan Patwardhan, Caterina Strambio-De-Castillia, Omer Ali Bayraktar, Jan Ellenberg, Andrii Iudin, Elizabeth Duke, Nicholas James Sofroniew, Thomas Lemberger, Mary Barlow, Emmanuel Gustin, Paul Verkade, Maria Harkiolaki, Lenard M. Voortman, Jo McEntyre, Alvis Brazma, Nadine Utz, M. Romanchikova, Christian Tischer, Matthew R. G. Russell, Lucy M. Collinson, Helen Parkinson
Publikováno v:
Nat Methods
Nature Methods, 18, 1418-1422. NATURE RESEARCH
Nature Methods
Nature Methods, Nature Publishing Group, 2021, ⟨10.1038/s41592-021-01166-8⟩
Nature Methods, 2021, ⟨10.1038/s41592-021-01166-8⟩
et al. 2021, ' REMBI: Recommended Metadata for Biological Images : enabling reuse of microscopy data in biology ', Nature Methods, vol. 18, no. 12, pp. 1418-1422 . https://doi.org/10.1038/s41592-021-01166-8
Nature Methods, 18, 1418-1422. NATURE RESEARCH
Nature Methods
Nature Methods, Nature Publishing Group, 2021, ⟨10.1038/s41592-021-01166-8⟩
Nature Methods, 2021, ⟨10.1038/s41592-021-01166-8⟩
et al. 2021, ' REMBI: Recommended Metadata for Biological Images : enabling reuse of microscopy data in biology ', Nature Methods, vol. 18, no. 12, pp. 1418-1422 . https://doi.org/10.1038/s41592-021-01166-8
Bioimaging data have significant potential for reuse, but unlocking this potential requires systematic archiving of data and metadata in public databases. We propose draft metadata guidelines to begin addressing the needs of diverse communities withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00e62ec205b43631b3b94003fdeb930
https://pubmed.ncbi.nlm.nih.gov/34021280
https://pubmed.ncbi.nlm.nih.gov/34021280
Autor:
Tinne Verhulst, Lieven Meerpoel, Emmanuel Gustin, Weimei Sun, Matthew V. Lorenzi, Junchen Gu, Longen Zhou, Wim Bert Griet Schepens, Hillary Millar, Tongfei Wu, Viellevoye Marcel, Vineet Pande, Petra Vinken, Desiree De Lange, An Boeckx, Christopher Moy, Friederike Pastore, Geert Mannens, Sylvie Laquerre, Ulrike Philippar, Vipul Bhargava, Gaston Stanislas Marcella Diels, Thomas Nys, Kathryn Packman, Jan Willem Thuring, Erika van Heerde, Bie Verbist, Sumit Rai, Lijs Beke, Pegah Safabakhsh, Timothy A. Graubert, Yue Fan, Angelique N Gilbert, Dirk Brehmer, Vikki Keersmaekers, Barbara Morschhäuser, Danilo Fiore, David Walker, Amy J. Johnson
Publikováno v:
Molecular cancer therapeutics. 20(12)
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required for cellular p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bff6d3af11d308608e3ab20a3144c14
https://pubmed.ncbi.nlm.nih.gov/34583982
https://pubmed.ncbi.nlm.nih.gov/34583982
Autor:
Laure Cougnaud, Hugo Ceulemans, Seong Joo Koo, Jelle Van de Waeter, Jean-Marc Neefs, Emmanuel Gustin, Jörg K. Wegner, Hinrich W. H. Göhlmann, Margino Steemans, Ilse Van den Wyngaert, Michael J. Cox, Soulaiman Benalla, Steffen Jaensch, Pieter J. Peeters, Yolanda T. Chong, Daan Seynaeve, Dmitry Malkov, Mart Bittremieux
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Phenomic profiles are high-dimensional sets of readouts that can comprehensively capture the biological impact of chemical and genetic perturbations in cellular assay systems. Phenomic profiling of compound libraries can be used for compound target i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ad9da8d1ef2e11a2c7e73ab2912140
Autor:
Danielle Peeters, Sarah Sauviller, Emmanuel Gustin, Peter Vermeulen, Jan Martin Berke, Dirk Wuyts, Frederik Pauwels, Koen Vandyck, Steffen Jaensch, Karen Vergauwen
Publikováno v:
Journal of Virological Methods. 293:114150
Hepatitis B Virus (HBV) core protein has multiple functions in the viral life cycle and is an attractive target for new anti-viral therapies. Capsid assembly modulators (CAMs) target the core protein and induce the formation of either morphologically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c0e6c6dae9b7885d2b9f2dff195934
https://doi.org/10.1016/j.jviromet.2021.114150
https://doi.org/10.1016/j.jviromet.2021.114150
Autor:
Adam Arany, Jörg K. Wegner, Jorge Vialard, Vladimir Chupakhin, Marvin Steijaert, Anne E. Carpenter, Shantanu Singh, Peter Jacobus Johannes Antonius Buijnsters, Yves Moreau, Jaak Simm, Emmanuel Gustin, Ingrid Velter, Roel Wuyts, Sepp Hochreiter, A. Vapirev, Yolanda T. Chong, Hugo Ceulemans, Günter Klambauer
In both academia and the pharmaceutical industry, large-scale assays for drug discovery are expensive and often impractical, particularly for the increasingly important physiologically relevant model systems that require primary cells, organoids, who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdc9b02e29c077539f5f8d0bd2c0b57
https://lirias.kuleuven.be/handle/123456789/628737
https://lirias.kuleuven.be/handle/123456789/628737
Autor:
Jorge Vialard, Vladimir Chupakhin, Yves Moreau, Günter Klambauer, Shantanu Singh, Marvin Steijaert, Adam Arany, Sepp Hochreiter, Anne E. Carpenter, Hugo Ceulemans, Roel Wuyts, Emmanuel Gustin, Jörg K. Wegner, Peter Jacobus Johannes Antonius Buijnsters, A. Vapirev, Ingrid Velter, Jaak Simm, Yolanda T. Chong
We repurpose a High-Throughput (cell) Imaging (HTI) screen of a glucocorticoid receptor assay to predict target protein activity in multiple other seemingly unrelated assays. In two ongoing drug discovery projects, our repurposing approach increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0059d469db8ccdab4e892970cfab25d3
Autor:
Amy Axel, Dirk Wuyts, Nele Vloemans, Pieter J. Peeters, Lut Janssen, Ronald de Hoogt, Eberhard Krausz, Emmanuel Gustin, Thierry Grand-Perret, Brett Hall, Sandy Frans, Miroslav Cik, Frans Cornelissen
Publikováno v:
SLAS Discovery. 18:54-66
For drug discovery, cell-based assays are becoming increasingly complex to mimic more realistically the nature of biological processes and their diversifications in diseases. Multicellular co-cultures embedded in a three-dimensional (3D) matrix have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e86b36982d34af6c11b7a714ea7b656
https://doi.org/10.1177/1087057112456874
https://doi.org/10.1177/1087057112456874
Autor:
Frans Cornelissen, Ronald de Hoogt, Ralph Graeser, Kjersti Gjerde, Michaël Barbier, Suzana Vidic, Emmanuel Gustin, Yolanda T. Chong, Steffen Jaensch
Publikováno v:
PLoS One (print), 11(6):e0156942. Public Library of Science
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0156942 (2016)
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0156942 (2016)
In oncology, two-dimensional in-vitro culture models are the standard test beds for the discovery and development of cancer treatments, but in the last decades, evidence emerged that such models have low predictive value for clinical efficacy. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e6dbbd3fa21fcbaa9a2892287e4c90
https://pure.eur.nl/en/publications/11655390-2cbc-4ed9-b0a4-68de6282fb16
https://pure.eur.nl/en/publications/11655390-2cbc-4ed9-b0a4-68de6282fb16