Zobrazeno 1 - 10
of 1 170
pro vyhledávání: '"Emmanouil T"'
Autor:
Nikolaos M. R. Lykoskoufis, Evarist Planet, Halit Ongen, Didier Trono, Emmanouil T. Dermitzakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Transposable elements (TEs) are prevalent repeats in the human genome, play a significant role in the regulome, and their disruption can contribute to tumorigenesis. However, TE influence on gene expression in cancer remains unclear. Here, w
Externí odkaz:
https://doaj.org/article/751f2c122b234bc69f931cf20a362f13
Autor:
Emmanouil T. Papakostas, Efthymios Papasoulis, Willem Cornelis de Jong, Aristotelis S. Sideridis, Argiris Karavelis, Konstantinos Epameinontidis, Ioannis P. Terzidis
Publikováno v:
Journal of Cartilage & Joint Preservation, Vol 4, Iss 2, Pp 100170- (2024)
Introduction: The direct reimplantation of autologous primary articular chondrocytes in a single-stage procedure for knee cartilage lesions is a novel approach, yet to be extensively reported. This study aimed to evaluate the clinical outcomes and re
Externí odkaz:
https://doaj.org/article/ee636473e872494ebf4b1a2369133c59
Autor:
Andrew A. Brown, Juan J. Fernandez-Tajes, Mun-gwan Hong, Caroline A. Brorsson, Robert W. Koivula, David Davtian, Théo Dupuis, Ambra Sartori, Theodora-Dafni Michalettou, Ian M. Forgie, Jonathan Adam, Kristine H. Allin, Robert Caiazzo, Henna Cederberg, Federico De Masi, Petra J. M. Elders, Giuseppe N. Giordano, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Alison J. Heggie, Cédric Howald, Angus G. Jones, Tarja Kokkola, Markku Laakso, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Donna McEvoy, Miranda Mourby, Petra B. Musholt, Birgitte Nilsson, Francois Pattou, Deborah Penet, Violeta Raverdy, Martin Ridderstråle, Luciana Romano, Femke Rutters, Sapna Sharma, Harriet Teare, Leen ‘t Hart, Konstantinos D. Tsirigos, Jagadish Vangipurapu, Henrik Vestergaard, Søren Brunak, Paul W. Franks, Gary Frost, Harald Grallert, Bernd Jablonka, Mark I. McCarthy, Imre Pavo, Oluf Pedersen, Hartmut Ruetten, Mark Walker, The DIRECT Consortium, Jerzy Adamski, Jochen M. Schwenk, Ewan R. Pearson, Emmanouil T. Dermitzakis, Ana Viñuela
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype,
Externí odkaz:
https://doaj.org/article/03b888dddec54ecd93647492ab5dd5aa
Autor:
Konstantinos Rouskas, Efthymia A. Katsareli, Charalampia Amerikanou, Alexandros C. Dimopoulos, Stavros Glentis, Alexandra Kalantzi, Anargyros Skoulakis, Nikolaos Panousis, Halit Ongen, Deborah Bielser, Alexandra Planchon, Luciana Romano, Vaggelis Harokopos, Martin Reczko, Panagiotis Moulos, Ioannis Griniatsos, Theodoros Diamantis, Emmanouil T. Dermitzakis, Jiannis Ragoussis, George Dedoussis, Antigone S. Dimas
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background Expression quantitative trait loci (eQTL) studies provide insights into regulatory mechanisms underlying disease risk. Expanding studies of gene regulation to underexplored populations and to medically relevant tissues offers pote
Externí odkaz:
https://doaj.org/article/838d0c2e8e08407b91ad6f33fb6cc010
Autor:
Diana Avalos, Guillaume Rey, Diogo M. Ribeiro, Anna Ramisch, Emmanouil T. Dermitzakis, Olivier Delaneau
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
An analysis of cis-regulatory domains (CRDs) among monocytes, neutrophils, and T cells derived from ChIP-seq peaks and methylation data suggests cell-type specific regulatory mechanisms of immunity.
Externí odkaz:
https://doaj.org/article/32975dc4f57f4a8c9b7aaf8d5781771f
Autor:
Chiara Medaglia, Ilya Kolpakov, Arnaud Charles-Antoine Zwygart, Yong Zhu, Samuel Constant, Song Huang, Valeria Cagno, Emmanouil T. Dermitzakis, Francesco Stellacci, Ioannis Xenarios, Caroline Tapparel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
When combined with interferon lambda, virucidal sialylated cyclodextrins inhibit the replication of a clinical H1N1 influenza strain in ex vivo human airway epithelia more efficiently than when delivered alone.
Externí odkaz:
https://doaj.org/article/ba1b4f2c59c04da492b309b10c561e18
Autor:
Neha Mishra, Konrad Aden, Johanna I. Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B. Sørensen, Silja H. Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A. Lyons, Joachim L. Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T. Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background and aims Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamic
Externí odkaz:
https://doaj.org/article/533221e6756c4c1d84dece9aba5649b6
Autor:
Theodorakys Marín Fermín, Filippo Migliorini, Giorgos Kalifis, Bashir Ahmed Zikria, Pieter D’Hooghe, Khalid Al-Khelaifi, Emmanouil T. Papakostas, Nicola Maffulli
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 17, Iss 1, Pp 1-13 (2022)
Abstract Purpose This systematic review evaluated the clinical outcomes of hardware-free MPFL reconstruction techniques in patients with recurrent patellofemoral instability, focusing on patient-reported outcome measures (PROMs), redislocation rate,
Externí odkaz:
https://doaj.org/article/e16a25ee86d84c22937455ab62be53c7
Autor:
Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T. Dermitzakis, Yurii S. Aulchenko, Thomas Lengauer, Paul A. Lyons, Michel Georges, Jörn Walter
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-17 (2021)
Abstract Background Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for determining methylation
Externí odkaz:
https://doaj.org/article/30a51dbae5e54fd38f1a974aab6c0fbe
Autor:
Diogo M. Ribeiro, Simone Rubinacci, Anna Ramisch, Robin J. Hofmeister, Emmanouil T. Dermitzakis, Olivier Delaneau
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Local gene co-expression is found throughout the genome, but systematic analysis of these co-expressed genes is needed. Here, the authors identify local co-expressed genes in 49 tissues and characterize the genetic variants which may affect their exp
Externí odkaz:
https://doaj.org/article/631aadc85a424e45a6de0ce58d753ad5