Výsledky vyhledávání - "Emmanouil, Papasavvas"

Akademický článek

Immune correlates of therapy outcomes in women with cervical cancer treated with chemoradiotherapy: A systematic review

Autor: David S. Lakomy, Juliana Wu, Dorothy Lombe, Emmanouil Papasavvas, Susan Citonje Msadabwe, Yimin Geng, Luis J. Montaner, Elizabeth Chiao, Lilie L. Lin

Publikováno v: Cancer Medicine, Vol 10, Iss 13, Pp 4206-4220 (2021)

Abstract Background Immune markers have been correlated with prognosis in a variety of solid tumors, including cervical cancer. Objective To review the literature on hematologic and immune markers and their association with recurrence and survival am

Externí odkaz: https://doaj.org/article/e855cd46b0c34159af90a19aa6c9f343

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Akademický článek

Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV

Autor: Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Radwa Sharaf, Behzad Etemad, Mohammad Damra, Aaron R. Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Alan Landay, Luis J. Montaner, Jeffrey M. Jacobson, Jonathan Z. Li, Mohamed Abdel-Mohsen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning

Externí odkaz: https://doaj.org/article/8389144aeb1a4d6d950f9fd144f01fe1

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Akademický článek

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption

Autor: Leila B. Giron, Emmanouil Papasavvas, Xiangfan Yin, Aaron R. Goldman, Hsin-Yao Tang, Clovis S. Palmer, Alan L. Landay, Jonathan Z. Li, John R. Koethe, Karam Mounzer, Jay R. Kostman, Qin Liu, Luis J. Montaner, Mohamed Abdel-Mohsen

Publikováno v: mBio, Vol 12, Iss 1 (2021)

The likelihood of HIV rebound after stopping antiretroviral therapy (ART) is a combination of the size of HIV reservoirs that persist despite ART and the host immunological and inflammatory factors that control these reservoirs. Therefore, there is a

Externí odkaz: https://doaj.org/article/0fa9e9d892ae46d3801779a44629a2bb

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Akademický článek

Interferon-α alters host glycosylation machinery during treated HIV infection

Autor: Leila B. Giron, Florent Colomb, Emmanouil Papasavvas, Livio Azzoni, Xiangfan Yin, Matthew Fair, Alitzel Anzurez, Mohammad Damra, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Una O'Doherty, Hiroaki Tateno, Qin Liu, Michael R. Betts, Luis J. Montaner, Mohamed Abdel-Mohsen

Publikováno v: EBioMedicine, Vol 59, Iss , Pp 102945- (2020)

Background: A comprehensive understanding of host factors modulated by the antiviral cytokine interferon-α (IFNα) is imperative for harnessing its beneficial effects while avoiding its detrimental side-effects during HIV infection. Cytokines modula

Externí odkaz: https://doaj.org/article/fab31996f60c46fa9d6c34db3d611550

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Akademický článek

Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling

Autor: Florent Colomb, Leila B. Giron, Thomas A. Premeaux, Brooks I. Mitchell, Toshiro Niki, Emmanouil Papasavvas, Luis J. Montaner, Lishomwa C. Ndhlovu, Mohamed Abdel-Mohsen

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Endogenous plasma levels of the immunomodulatory carbohydrate-binding protein galectin-9 (Gal-9) are elevated during HIV infection and remain elevated after antiretroviral therapy (ART) suppression. We recently reported that Gal-9 regulates HIV trans

Externí odkaz: https://doaj.org/article/3d2e327c70ed42f084495df2abed41f0

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