Výsledky vyhledávání - "Emmalene J, Bartlett"

Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium

Autor: Margaret A. Scull, Alexander C. Schmidt, Raymond J. Pickles, Rachael M. Liesman, Anne Schaap-Nutt, Peter L. Collins, Emmalene J. Bartlett

Publikováno v: Virology. 433:320-328

Human parainfluenza viruses (PIVs) cause acute respiratory illness in children, the elderly, and immunocompromised patients. PIV3 is a common cause of bronchiolitis and pneumonia, whereas PIV1 and 2 are frequent causes of upper respiratory tract illn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3da3f1b2bc37a91cb3cca549e9ca0e9
https://doi.org/10.1016/j.virol.2012.08.027

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A novel human parainfluenza virus type 1 (HPIV1) with separated P and C genes is useful for generating C gene mutants for evaluation as live-attenuated virus vaccine candidates

Autor: Janice Esker, Peter L. Collins, Jim Boonyaratanakornkit, Ann-Marie Cruz, Mario H. Skiadopoulos, Alexander C. Schmidt, Adam Castaño, Emmalene J. Bartlett, Brian R. Murphy

Publikováno v: Vaccine. 28:767-779

A novel recombinant human parainfluenza virus type 1 (rHPIV1), rHPIV1-C+P, in which the overlapping open reading frames of the C and P genes were separated in order to introduce mutations into the C gene without affecting P, was generated. Infectious

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd6bb84f67b2a51ffe5ed005ca4fa25
https://doi.org/10.1016/j.vaccine.2009.10.069

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The C Proteins of Human Parainfluenza Virus Type 1 (HPIV1) Control the Transcription of a Broad Array of Cellular Genes That Would Otherwise Respond to HPIV1 Infection

Autor: Emerito Amaro-Carambot, Brian R. Murphy, Emmalene J. Bartlett, Jim Boonyaratanakornkit, Alexander C. Schmidt, Peter L. Collins

Publikováno v: Journal of Virology. 83:1892-1910

Human parainfluenza virus type 1 (HPIV1) is an important respiratory pathogen in children and the most common cause of viral croup. We performed a microarray-based analysis of gene expression kinetics to examine how wild-type (wt) HPIV1 infection alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e25ebb0c77b0bd2f4bde86f272e7fb
https://doi.org/10.1128/jvi.01373-08

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Human Parainfluenza Virus Type 1 C Proteins Are Nonessential Proteins That Inhibit the Host Interferon and Apoptotic Responses and Are Required for Efficient Replication in Nonhuman Primates

Autor: Janice Esker, Murphy Brian R, Henrick Schomacker, Peter L. Collins, Alexander C. Schmidt, Raymond J. Pickles, Sonja R. Surman, Adam Castaño, Emmalene J. Bartlett, Jim Boonyaratanakornkit, Ann Marie Cruz, Margaret Hennessey

Publikováno v: Journal of Virology. 82:8965-8977

Recombinant human parainfluenza virus type 1 (rHPIV1) was modified to create rHPIV1-P(C−), a virus in which expression of the C proteins (C′, C, Y1, and Y2) was silenced without affecting the amino acid sequence of the P protein. Infectious rHPIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f32b3a864597184e2f0a0ef95be8ac7
https://doi.org/10.1128/jvi.00853-08

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Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein

Autor: Mohammad Yazid Abdad, Cassandra M. James, Azita Rezazadeh Vind, Hege K. Jacobsen, Emmalene J. Bartlett, Philip A. Stumbles, Josephine P. Mansfield

Publikováno v: Vaccine. 25:1856-1867

Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6387b209bfe36715ba39fa268604ddc8
https://doi.org/10.1016/j.vaccine.2006.10.038

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Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1

Autor: William Van Cleve, Mario H. Skiadopoulos, Joseph Bekisz, Sonja R. Surman, Peter L. Collins, Kathryn C. Zoon, Brian R. Murphy, Emerito Amaro-Carambot, Emmalene J. Bartlett

Publikováno v: Virology. 352(1):61-73

Recombinant human parainfluenza virus type 1 (HPIV1) and mutants containing point and deletion (Δ) mutations in the P/C gene (r-C Δ10–15 HN T553A , r-C R84G , r-C F170S and r-C Δ170 ), which have previously been evaluated as HPIV1 vaccine candid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430725ff1d8b7429a3b9d7c603383116

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Optimization of Naked DNA Delivery for Interferon Subtype Immunotherapy in Cytomegalovirus Infection

Autor: Josephine P. Mansfield, Emmalene J. Bartlett, Eva N. Mowe, Cassandra M. James, Vanessa S. Cull

Publikováno v: Biological Procedures Online, Vol 5, Iss 1, Pp 43-52 (2003)
Biological Procedures

Type I interferon (IFN) gene therapy modulates the immune response leading to inflammatory heart disease following cytomegalovirus (CMV) infection in a murine model of post-viral myocarditis. Efficacy of different immunisation protocols for the IFN c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032ce7a29e7f50526398736e5ee735ab
http://www.biologicalprocedures.com/bpo/arts/1/45/m45.htm

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Coimmunisation with type I IFN genes enhances protective immunity against cytomegalovirus and myocarditis in gB DNA-vaccinated mice

Autor: Vanessa S. Cull, Natalie L. Brekalo, Emmalene J. Bartlett, S. Broomfield, Cassandra M. James

Publikováno v: Gene Therapy. 9:1369-1378

Viral DNA vaccines encoding the glycoprotein B (gB) of cytomegalovirus provide partial protective immunity upon challenge with infectious virus. Although it is known that type I IFN can stimulate the adaptive immune response, their direct use in vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af86471ecda3caabfa3522e0b7b677c6
https://doi.org/10.1038/sj.gt.3301809

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Type I interferon gene therapy protects against cytomegalovirus-induced myocarditis

Autor: Cassandra M. James, Vanessa S. Cull, Emmalene J. Bartlett

Publikováno v: Immunology. 106:428-437

Type I interferons (IFNs) are produced early in response to viral infection and modulate adaptive immunity. Previously we demonstrated localized protection against murine cytomegalovirus (MCMV) infection in IFN DNA-inoculated mice. Here we examine th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa79649fbf5c25a1b5f959369358cc79
https://doi.org/10.1046/j.1365-2567.2002.01423.x

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