Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emma-Jane Williams"'
Autor:
Gareth Williams, Ying Gao, Brian Bates, Menelas N. Pangalos, Joe Zaccardi, Frank S. Walsh, Emma-Jane Williams, Ann Aulabaugh, Yuhong Xie, Alan H. Katz, Andrew Wood, Patrick Doherty, Diane Joseph-McCarthy, Mary Lynn T. Mercado, Huai-Ping Ling
Publikováno v:
Journal of Biological Chemistry. 283:16641-16652
Gangliosides are key players in neuronal inhibition, with antibody-mediated clustering of gangliosides blocking neurite outgrowth in cultures and axonal regeneration post injury. In this study we show that the ganglioside GT1b can form a complex with
Autor:
Gareth Williams, Patrick Doherty, Emma-Jane Williams, Stephen D. Skaper, Frank S. Walsh, Laura Facci
Publikováno v:
Molecular and Cellular Neuroscience. 26:17-23
The HAVDI and INPISGQ sequences have been identified as functional binding motifs in extracellular domain 1 (ECD1) of N-cadherin. Cyclic peptides containing a tandem repeat of the individual motifs function as N-cadherin agonists and stimulate neurit
Publikováno v:
The Journal of Cell Biology
Akey role for DAG lipase activity in the control of axonal growth and guidance in vitro and in vivo has been established. For example, DAG lipase activity is required for FGF-stimulated calcium influx into neuronal growth cones, and this response is
Autor:
Emma-Jane Williams, Fiona V. Howell, Isabel Matias, Vincenzo Di Marzo, Praveen Paul, Alberto Minassi, Gareth Williams, Carl Hobbs, Maria Grazia Cascio, Patrick Doherty, Tiziana Bisogno, Aniello Schiano-Moriello, Alessia Ligresti, Uma Gangadharan
Publikováno v:
The Journal of Cell Biology
Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the endocannabinoid 2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid recept
Autor:
Frank S. Walsh, Stephen D. Skaper, Emma-Jane Williams, Gareth Williams, Fiona V. Howell, Patrick Doherty
Publikováno v:
Journal of Biological Chemistry. 276:43879-43886
In this study, we show that the neurite outgrowth response stimulated by N-cadherin is inhibited by a recently developed and highly specific fibroblast growth factor receptor (FGFR) antagonist. To test whether the N-cadherin response also requires FG
Publikováno v:
Molecular and Cellular Neuroscience. 15:456-464
The classical cadherins are homophilic binding molecules that play fundamental roles in several biological processes, including axonal growth and synaptic plasticity. The structures of the amino-terminal homophilic binding domains of N-cadherin and E
Autor:
Emma-Jane Williams, Patrick Doherty
Publikováno v:
Molecular and Cellular Neuroscience. 13:272-280
PI 3-kinase has emerged as a key enzyme for regulating neuronal cell survival. However, it has not as yet been demonstrated whether activation of the endogenous pool of the enzyme, that is regulated by the p85 subunit, is sufficient to promote a surv
Autor:
Maria Beatriz, Goncalves, Emma-Jane, Williams, Ping, Yip, Rafael J, Yáñez-Muñoz, Gareth, Williams, Patrick, Doherty
Publikováno v:
British journal of pharmacology. 159(5)
In adults, neurogenesis persists in the hippocampus and the subventricular zone (SVZ), and this is important for learning and memory. Inhibitors of COX-2 suppress ischaemia-induced neurogenesis in the hippocampus. Here, we have determined the effects
Autor:
Gareth, Williams, Andrew, Wood, Emma-Jane, Williams, Ying, Gao, Mary L, Mercado, Alan, Katz, Diane, Joseph-McCarthy, Brian, Bates, Huai-Ping, Ling, Ann, Aulabaugh, Joe, Zaccardi, Yuhong, Xie, Menelas N, Pangalos, Frank S, Walsh, Patrick, Doherty
Publikováno v:
The Journal of biological chemistry. 283(24)
Gangliosides are key players in neuronal inhibition, with antibody-mediated clustering of gangliosides blocking neurite outgrowth in cultures and axonal regeneration post injury. In this study we show that the ganglioside GT1b can form a complex with
Autor:
Frank S. Walsh, Menelas N. Pangalos, Gareth Williams, Patrick Doherty, Patrick Maison, Emma-Jane Williams
Publikováno v:
The Journal of biological chemistry. 280(7)
Myelin inhibitors activate a p75(NTR)-dependent signaling cascade in neurons that not only inhibits axonal growth but also prevents neurotrophins (NT) from stimulating growth. Most intriguingly, in addition to Trk receptors, neurotrophins also bind t