Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Emma V. Morris"'
Autor:
Houfu Leng, Hanlin Zhang, Linsen Li, Shuhao Zhang, Yanping Wang, Selina J. Chavda, Daria Galas-Filipowicz, Hantao Lou, Adel Ersek, Emma V. Morris, Erdinc Sezgin, Yi-Hsuan Lee, Yunsen Li, Ana Victoria Lechuga-Vieco, Mei Tian, Jian-Qing Mi, Kwee Yong, Qing Zhong, Claire M. Edwards, Anna Katharina Simon, Nicole J. Horwood
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here, the authors show that the glycosylceramide synthesis inhibitor and FDA approved drug Eliglustat inhibits autophagic degradation of TRAF3 which is a key step for osteoclast differentiation and thereby improves myeloma bone lesions.
Externí odkaz:
https://doaj.org/article/d3f4b2b671d34e5f9416142c53caf80d
Autor:
Beatriz Gámez, Emma V. Morris, Sam W.Z. Olechnowicz, Siobhan Webb, James R. Edwards, Aneka Sowman, Christina J. Turner, Claire M. Edwards
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101301- (2022)
Multiple myeloma is a haematological malignancy that is dependent upon interactions within the bone microenvironment to drive tumour growth and osteolytic bone disease. Metformin is an anti-diabetic drug that has attracted attention due to its direct
Externí odkaz:
https://doaj.org/article/8d405455344f4b739180c3e642c0eb66
Autor:
Sarah Gooding, Sam W. Z. Olechnowicz, Emma V. Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease
Externí odkaz:
https://doaj.org/article/afce39d2e8774212826676e3142ffc40
Autor:
Beatriz Gamez, Emma V. Morris, Sam W.Z. Olechnowicz, Aneka Sowman, Christina J. Turner, Claire M. Edwards
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100681- (2020)
Externí odkaz:
https://doaj.org/article/f092053f74dc4d8f80e2f14a1cc3cc02
Autor:
Beatriz Gamez, Emma V. Morris, Sam W.Z. Olechnowicz, Sowman Aneka, Christina J. Turner, Seint T. Lwin, Matthew T. Drake, Claire M. Edwards
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100331- (2020)
Externí odkaz:
https://doaj.org/article/522f1a002b8d4b15aa47be05e3e282a6
Autor:
Emma V. Morris, Claire M. Edwards
Publikováno v:
Journal of Bone Oncology, Vol 5, Iss 3, Pp 121-123 (2016)
Adipocytes are a significant component of the bone marrow microenvironment. Although bone marrow adipocytes were first identified more than 100 years ago, it is only in recent years that an understanding of their complex physiological role is emergin
Externí odkaz:
https://doaj.org/article/b82cedca77d349608fd1d6153a711e37
Autor:
Jessica Whitburn, Srinivasa R. Rao, Emma V. Morris, Sho Tabata, Akiyoshi Hirayama, Tomoyoshi Soga, James R. Edwards, Zeynep Kaya, Charlotte Palmer, Freddie C. Hamdy, Claire M. Edwards
Publikováno v:
Science Advances. 8
The spread of cancer to bone is invariably fatal, with complex cross-talk between tumor cells and the bone microenvironment responsible for driving disease progression. By combining in silico analysis of patient datasets with metabolomic profiling of
Autor:
Claire M. Edwards, Emma V. Morris
Publikováno v:
Cellular and Molecular Life Sciences
Multiple myeloma is a malignancy caused by the clonal expansion of abnormal plasma cells. Myeloma cells have proven to be incredibly successful at manipulating their microenvironment to promote growth and to evade modern therapies. They have evolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d638af227dd2bce24c261c2b9b350e
https://doi.org/10.1007/s00018-021-03767-0
https://doi.org/10.1007/s00018-021-03767-0
Autor:
Beatriz Gámez, Emma V. Morris, Sam W.Z. Olechnowicz, Siobhan Webb, James R. Edwards, Aneka Sowman, Christina J. Turner, Claire M. Edwards
Publikováno v:
Translational Oncology
Translational Oncology, Vol 15, Iss 1, Pp 101301-(2022)
Translational Oncology, Vol 15, Iss 1, Pp 101301-(2022)
Highlights • Metformin has unexpected indirect effects on the bone microenvironment to promote myeloma. • Pretreatment with metformin indirectly increases myeloma tumour burden in vivo. • Metformin increases myeloma cell adhesion to osteoblasts
Autor:
Ceiridwen J. Edwards, Li L, Houfu Leng, Anna Katharina Simon, Erdinc Sezgin, Adel Ersek, Zhong Q, Nicole J. Horwood, Yi Xin Fiona Lee, Yong-Feng Wang, Mi J, Li Y, Hanlin Zhang, Suyi Zhang, Emma V. Morris
Multiple myeloma (MM) is a fatal hematological malignancy, where the majority of patients are diagnosed with, or develop, destructive and debilitating osteolytic bone lesions. Current treatments for MM bone disease such as the bisphosphonate zoledron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9798cc254eba7398127aac37cad38b
https://doi.org/10.1101/2021.02.05.429906
https://doi.org/10.1101/2021.02.05.429906