Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Emma U. Hammarlund"'
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-r
Externí odkaz:
https://doaj.org/article/bcbd6c09da064051a756848a4f23f88c
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Sarah R. Amend, Robert H. Austin, Emma U. Hammarlund, Joel S. Brown
Publikováno v:
Ecology and Evolution, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms. By viewing this capacity as a trait, evolv
Externí odkaz:
https://doaj.org/article/7e4d9299408e4b9199e84cb6dae86b05
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Therapeutic resistance is one of the main reasons for treatment failure in cancer patients. The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by providing a refuge for cancer cells from the effects of therapy an
Externí odkaz:
https://doaj.org/article/5e255d74321e44159eab4104663af1f8
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell
Externí odkaz:
https://doaj.org/article/f9e258e630024871bac773c4cd734baa
Publikováno v:
Evolutionary Applications, Vol 13, Iss 7, Pp 1626-1634 (2020)
Abstract Cancer cells utilize the forces of natural selection to evolve evolvability allowing a constant supply of heritable variation that permits a cancer species to evolutionary track changing hazards and opportunities. Over time, the dynamic tumo
Externí odkaz:
https://doaj.org/article/5c85043ca8644fac9ca7b42ac79f96fd
Autor:
Christopher Carroll, Niklas Engström, Patrik F. Nilsson, Emma R. Haxen, Sofie Mohlin, Peter Berg, Ronnie N. Glud, Emma U. Hammarlund
Publikováno v:
Frontiers in Ecology and Evolution, Vol 9 (2021)
Cancer research has transformed our view on cellular mechanisms for oxygen sensing. It has been documented that these mechanisms are important for maintaining animal tissues and life in environments where oxygen (O2) concentrations fluctuate. In adul
Externí odkaz:
https://doaj.org/article/687091aaf5414bed8bc048174136b7fb
Publikováno v:
Molecules, Vol 26, Iss 24, p 7522 (2021)
Hair can record chemical information reflecting our living conditions, and, therefore, strands of hair have become a potent analytical target within the biological and forensic sciences. While early efforts focused on analyzing complete hair strands
Externí odkaz:
https://doaj.org/article/6e9a6db37cba4a28a5d3d978f4fef8a8
Autor:
Xiaomei Wang, Shuichang Zhang, Huajian Wang, Donald E. Canfield, Jin Su, Emma U. Hammarlund, Lizeng Bian
Publikováno v:
Geofluids, Vol 2017 (2017)
Prokaryotes, often generally referred to as “bacteria,” are the original and thus oldest life on Earth. They have shaped the chemical environment of the Earth, but they are difficult to find as ancient fossils due to their subtle structure. Here
Externí odkaz:
https://doaj.org/article/79aa00fe0db54b89b87287621f206277
Autor:
Mai H. Philipsen, Ellinor Hansson, Auraya Manaprasertsak, Stefan Lange, Eva Jennische, Helena Carén, Kliment Gatzinsky, Asgeir Jakola, Emma U. Hammarlund, Per Malmberg
Publikováno v:
ACS Chemical Neuroscience. 14:1602-1609
Autor:
Sarah R. Amend, Emma U. Hammarlund, Robert Axelrod, Kenneth J. Pienta, Joel S. Brown, Robert H. Austin
Publikováno v:
Pienta, K J, Hammarlund, E U, Austin, R H, Axelrod, R, Brown, J S & Amend, S R 2022, ' Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy ', Seminars in Cancer Biology, vol. 81, pp. 145-159 . https://doi.org/10.1016/j.semcancer.2020.11.016
Unusually large cancer cells with abnormal nuclei have been documented in the cancer literature since 1858. For more than 100 years, they have been generally disregarded as irreversibly senescent or dying cells, too morphologically misshapen and chro