Výsledky vyhledávání - "Emma T. Bowden"

Supplementary Figure 4 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

Autor: Adrian L. Harris, Richard Poulsom, Craig P. Montgomery, Angela J. Russell, Partha S. Chowdhury, Herren Wu, Emma T. Bowden, Cameron Snell, Wen Shi, Esther Bridges, Helen Sheldon, Russell Leek, Helen Turley, Chern Ein Oon, Richard C.A. Sainson, Ji-Liang Li

PDF file - 1.84 MB, Pericyte coverage on tumor microvessels did not associate with the tumor resistance to bevacizumab (bev). Fresh frozen tumor samples were taken from Figure 2D and double stained for CD31 (green) and the pericytic marker NG2 (red).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0d956ee57b02a5fab0aa923b49381d
https://doi.org/10.1158/0008-5472.22388571.v1

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Supplementary Figure 5 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF file - 4.04 MB, DLL4 downregulated the expression of VEGFR3 in human microvascular EC in vitro and in xenograft tumor in vivo. (A). The expression of VEGFR3 at a mRNA level was decreased in human micrcovascular EC (hMEC-1) cultured in vitro after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d6682e3b89fae90af9419c56c02c8
https://doi.org/10.1158/0008-5472.22388568.v1

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Supplementary Figure 1 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF file - 473K, Blockade of Notch signaling in endothelial cells by DBZ in vitro. Western blotting showed that the protein levels of activated Notch intracellular domain (NICD) and Hes-1 were significantly reduced by DBZ in human umbilical vein endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1533a7921f0c60356f736c1c9a6af6
https://doi.org/10.1158/0008-5472.22388580.v1

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Supplementary Figure 6 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF file - 740K, Neither anti-EphrinB2 nor sEphB4 affected the growth of U87-EV tumors in vivo. Compared to the control, neutralizing anti-EphrinB2 antibody (B2) alone (blue arrowhead) did not affect the tumor growth. Also, combined anti-EphrinB2 ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3bbe38c8de0da3d76fe6a344de7054
https://doi.org/10.1158/0008-5472.22388565

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Supplementary Figure 2 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF 712K, In vivo expression of mHey1, a downstream target of Notch signaling in the mouse stroma/ECs of U87 tumors. The relative expression of mHey1 in tumor tissues was analyzed by qPCR against mRNA extracted from xenograft tumors using mouse speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4648d9cad903096a9fe67f46f350355a
https://doi.org/10.1158/0008-5472.22388577

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Supplementary Figure 3 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF 584K, Combination therapy by blockade of both Notch signaling and the VEGF pathway displayed a synergistic therapeutic efficacy in HT1080 xenografted tumors. Single therapy with either DBZ or bevacizumab did not affect tumor growth and animal sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c54692481d24888a75550c2919dfee4
https://doi.org/10.1158/0008-5472.22388574

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Abstract LB-182: Notch signaling pathway is transcriptionally elevated in anaplastic thyroid cancer

Autor: Bharvin K. R. Patel, Hui-Rong Qian, Emma T. Bowden, Karim A. Benhadji, Gerald Joseph Oakley, Amit Aggarwal, Yan Ding

Publikováno v: Cancer Research. 78:LB-182

Anaplastic thyroid cancer (ATC), contrary to well-differentiated papillary thyroid cancer (PTC), is one of the most aggressive human malignancies. Anaplastic thyroid cancer is responsible for more than half of all thyroid cancer deaths, with an overa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce6790dfbc08e777dfe8336e3b2c10f1
https://doi.org/10.1158/1538-7445.am2018-lb-182

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Abstract 2586: PI3K/AKT signaling pathway is transcriptionally elevated in prexasertib-resistant TNBC PDX models

Autor: Philip J. Ebert, Aimee Bence Lin, Ricardo Martinez, Jiangang Liu, Yan Ding, Gregory P. Donoho, Hui-Rong Qian, Richard P. Beckmann, John N. Calley, Wenjuan Wu, Philip W. Iversen, Emma T. Bowden, Amit Aggarwal

Publikováno v: Cancer Research. 78:2586-2586

Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor clinical outcomes and limited treatment options. Transcriptional analysis has divided TNBC into different molecular subtypes (BL1, BL2, M and LAR) that were charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bab3de469e7635cb1a8d8901cd25b58f
https://doi.org/10.1158/1538-7445.am2018-2586

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