Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Emma Shtivelman"'
Autor:
Vivian Chen, Richard E Staub, Scott Baggett, Ramesh Chimmani, Mary Tagliaferri, Isaac Cohen, Emma Shtivelman
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30107 (2012)
Bezielle is a botanical extract that has selective anti-tumor activity, and has shown a promising efficacy in the early phases of clinical testing. Bezielle inhibits mitochondrial respiration and induces reactive oxygen species (ROS) in mitochondria
Externí odkaz:
https://doaj.org/article/5d5774ccf8094d09a64555b1fc608047
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30300 (2012)
Bezielle (BZL101) is a candidate oral drug that has shown promising efficacy and excellent safety in the early phase clinical trials for advanced breast cancer. Bezielle is an aqueous extract from the herb Scutellaria barbata. We have reported previo
Externí odkaz:
https://doaj.org/article/97dca8100f9b42eca539d195c717e2bd
Autor:
Frank W King, Sylvia Fong, Chandi Griffin, Mark Shoemaker, Rick Staub, Yan-Ling Zhang, Isaac Cohen, Emma Shtivelman
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7283 (2009)
The aqueous extract of Anemarrhena asphodeloides (BN108) induces apoptosis in various cancer cell lines but is significantly less cytotoxic in non-transformed cells. Chemical fractionation of BN108 showed that its cytotoxicity is associated with timo
Externí odkaz:
https://doaj.org/article/bbba70b854f04f94bbbfb81984ca8160
Publikováno v:
Cancer Research. 83:4255-4255
Pancreatic cancer is one of the most fatal of all cancers. Pancreatic adenocarcinomas have been historically difficult to treat, in part due to lack of early detection, and due to their resistance to conventional chemotherapy. There has recently been
Publikováno v:
Oncotarget, vol 5, iss 17
Oncotarget
Oncotarget
Prostate cancer co-opts a unique set of cellular pathways in its initiation and progression. The heterogeneity of prostate cancers is evident at earlier stages, and has led to rigorous efforts to stratify the localized prostate cancers, so that progr
Autor:
Emma Shtivelman, Patrick Hwu, David E. Fisher, Keith T. Flaherty, Moshe Oren, Michael A. Davies, Michal Lotem, James Chih-Hsin Yang
Publikováno v:
Oncotarget
// Emma Shtivelman 1 , Michael A. Davies 2 , Patrick Hwu 2 , James Yang 3 , Michal Lotem 4 , Moshe Oren 5 , Keith T. Flaherty 6 , and David E. Fisher 6 1 Cancer Commons, Palo Alto, CA, USA 2 University of Texas MD Anderson Cancer Center, Houston, TX,
Autor:
Gregory A. Otterson, George R. Simon, Phillip A. Dennis, Ravi Salgia, Emma Shtivelman, Thomas A. Hensing, Raphael Bueno
Publikováno v:
Oncotarget
Lung cancer is still the leading cause of cancer death worldwide. Both histologically and molecularly lung cancer is heterogeneous. This review summarizes the current knowledge of the pathways involved in the various types of lung cancer with an emph
Autor:
Isaac Cohen, Mary Tagliaferri, Kyler Corby, Jennifer Gurshtein, Linda Quattrochi, Sylvia Fong, Jelena Klawitter, Emma Shtivelman, Jost Klawitter, Uwe Christians
Publikováno v:
International Journal of Cancer. 129:2945-2957
Bezielle is an orally administered aqueous extract of Scutellaria barbata for treatment of advanced and metastatic breast cancer. Phase I trials showed promising tolerability and efficacy. In our study, we used a combined proteomic-metabolomic approa
Autor:
Joan Climent, Emma Shtivelman, Mark Shoemaker, Isaac Cohen, Sylvia Fong, Dale C. Leitman, Chandi A. Griffin, Richard E. Staub, Ruth Chu, Xiaoyue Zhao
Publikováno v:
International Journal of Cancer. 127:1209-1219
Hormonal, targeted and chemotherapeutic strategies largely depend on the expression of their cognate receptors and are often accompanied by intolerable toxicities. Effective and less toxic therapies for estrogen receptor negative (ER-) breast cancers
Publikováno v:
Cell Cycle. 3:632-635
We have shown recently that DNA damage effector kinase Chk1 is phosphorylated in vitro by protein kinase B/Akt (PKB/Akt) on serine 280. Activation of Chk1 by DNA damage in vivo is suppressed in presence of activated PKB. In this study we show that Ch