Výsledky vyhledávání - "Emma Sanzari"

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

Autor: Pietro Campiglia, Guido Iaccarino, Bruno Trimarco, Ersilia Cipolletta, Dario Leosco, Emma Sanzari, Alfonso Campanile, Gaetano Santulli

Publikováno v: Cardiovascular Research. 84:407-415

AIMS: Insulin (Ins) resistance (IRES) associates to increased cardiovascular risk as observed in metabolic syndrome. Chronic stimulation of beta-adrenergic receptors (betaAR) due to exaggerated sympathetic nervous system activity is involved in the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8d555c8e6292e186acbfeef95c3d87
https://doi.org/10.1093/cvr/cvp252

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Prior Exercise Improves Age-Dependent Vascular Endothelial Growth Factor Downregulation and Angiogenesis Responses to Hind-Limb Ischemia in Old Rats

Autor: Carmela Zincarelli, Luca Golino, Emma Sanzari, Vincenzo Cimini, Walter J. Koch, Dario Leosco, Federico Piscione, Michele Ciccarelli, Giovanna Giuseppina Altobelli, Giuseppe Rengo, Franco Rengo, Gabriella De Lisa, Bruno Trimarco, Francesca Fortunato, Gennaro Galasso, Guido Iaccarino

Publikováno v: Scopus-Elsevier

Downregulation of hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF) are shown to be involved in age-dependent impairment of angiogenesis. In this study, we explore whether prior exercise is able to affect these molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15d5af12c51e4b820edf7f3bef524f6
https://doi.org/10.1093/gerona/62.5.471

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The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter

Autor: Claudio Pignata, Mariacarolina Salerno, Jlenia Monfregola, Michele D'Urso, Raffaele Ambrosio, Emma Sanzari, Giorgia Fimiani, Matilde Valeria Ursini, Nicola De Felice

Publikováno v: Gene. 285:311-318

STAT5A and STAT5B genes belong to the signal transducer and activators of transcription (STAT) family of transcription factors. They show a high degree of sequence homology at levels of mRNA, however, in spite of their supposed redundancy, each STAT5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e55879b3a4ba38829848ba6ba57bcf9
https://doi.org/10.1016/s0378-1119(02)00421-3

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Porins fromSalmonella entericaSerovar Typhimurium Activate the Transcription Factors Activating Protein 1 and NF-κB through the Raf-1-Mitogen-Activated Protein Kinase Cascade

Autor: Massimiliano Galdiero, Stefania Galdiero, Anna Longanella, Emma Sanzari, Marina D'Isanto, Annalisa Tortora, Mariateresa Vitiello

Publikováno v: Infection and Immunity. 70:558-568

In this study we examined the ability ofSalmonella entericaserovar Typhimurium porins to activate activating protein 1 (AP-1) and nuclear factor κB (NF-κB) through the mitogen-activated protein kinase (MAPK) cascade, and we identified the AP-1-indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a294bdfe82ac2e7e7daeea0b7d2db818
https://doi.org/10.1128/iai.70.2.558-568.2002

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Molecular anatomy of the human glucose 6-phosphate dehydrogenase core promoter

Autor: Francesca Fusco, Antonietta Santoro, Matilde Valeria Ursini, Maria Immacolata Ferrante, Annamaria Franzè, Giuseppe Martini, Emma Sanzari

Publikováno v: FEBS Letters. 437:313-318

The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a numb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be654f089b78f09e0abe94f4f44134ee
https://doi.org/10.1016/s0014-5793(98)01259-9

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Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart

Autor: Vincenzo Cimini, Amelia Filippelli, Guido Iaccarino, Massimo Marchese, Gianfranco Matrone, Carmela Zincarelli, Gennaro Galasso, Luca Golino, Giuseppe Rengo, Francesca Fortunato, Nicola Ferrara, Emma Sanzari, Walter J. Koch, Michele Ciccarelli, Franco Rengo, Giovanna Giuseppina Altobelli, Dario Leosco, Valeria Conti

Publikováno v: Leosco, D, Rengo, G, Iaccarino, G, Golino, L, Marchese, M, Fortunato, F, Zincarelli, C, Sanzari, E, Ciccarelli, M, Galasso, G, Altobelli, G G, Conti, V, Matrone, G, Cimini, V, Ferrara, N, Filippelli, A, Koch, W J & Rengo, F 2007, ' Exercise promotes angiogenesis and improves beta adrenergic receptor signaling in the post-ischemic failing rat heart. ', Cardiovascular Research, vol. 2, no. 78, pp. 385-94 . https://doi.org/10.1093/cvr/cvm109

Aims: We investigated whether exercise training could promote angiogenesis and improve blood perfusion and left ventricular (LV) remodelling of the post-myocardial infarction (MI) failing heart. We also explored the contribution of ameliorated beta-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ab2afbf123597d8fefff934770a11e
https://pubmed.ncbi.nlm.nih.gov/18093988

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Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease

Autor: V. Canonico, Emma Sanzari, Guido Iaccarino, Franco Rengo, Massimo Marchese, Dario Leosco, Walter J. Koch, Luca Golino, Francesca Fortunato, Giuseppe Rengo, Carmela Zincarelli

Alterations in signal transduction pathway of G-protein-coupled receptors (GPCRs) have been found in the cerebrocortex and in the peripheral cultured tissues of patients with Alzheimer's disease (AD). The G-protein-coupled receptor kinase-2 (GRK2) pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734a70ca9b9359cce5eabac3057053d9
http://hdl.handle.net/11588/368511

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Characterization of the human STAT5A and STAT5B promoters: evidence of a positive and negative mechanism of transcriptional regulation

Autor: Emma Sanzari, Jlenia Monfregola, Michele D'Urso, Stefania Crispi, Raffaele Ambrosio, Giorgia Fimiani, Matilde Valeria Ursini, Nicola De Felice

Publikováno v: FEBS letters
562 (2004): 27–34. doi:10.1016/S0014-5793(04)00166-8
info:cnr-pdr/source/autori:Crispi S.; Sanzari E.; Monfregola J.; De Felice N.; Fimiani G.; Ambrosio R.; D'Urso M.; Ursini M.V./titolo:Characterization of the human STAT5A and STAT5B promoters: evidence of a positive and negative mechanism of transcriptional regulation/doi:10.1016%2FS0014-5793(04)00166-8/rivista:FEBS letters (Print)/anno:2004/pagina_da:27/pagina_a:34/intervallo_pagine:27–34/volume:562

We recently published the genomic characterization of the STAT5A and STAT5B paralogous genes that are located head to head in the 17q21 chromosome and share large regions of sequence identity. We here demonstrate by transient in vitro transfection th

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