Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Emma S. Koeleman"'
Autor:
Lisa Koob, Anoek Friskes, Louise vanBergen, Femke M. Feringa, Bram van denBroek, Emma S. Koeleman, Ellis vanBeek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1192-1211 (2023)
Faithful and timely repair of DNA double‐strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co‐factor MND1 facilitates the repair of DSBs in somatic cells. We show tha
Externí odkaz:
https://doaj.org/article/e82d5294e0a84e3596d187a3bb227b86
Autor:
Adam Byron, Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex von Kriegsheim, Valerie G. Brunton, Margaret C. Frame
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cell adhesion proteins have been described at sites away from the cell surface, including in the nucleus. Here, the authors report the scale of nuclear localisation of adhesion proteins, establishing a nucleo-adhesome and showing that nuclear adhesio
Externí odkaz:
https://doaj.org/article/83349dab846e4f55a388ec199c877673
Autor:
Anoek Friskes, Lisa Koob, Lenno Krenning, Tesa M Severson, Emma S Koeleman, Xabier Vergara, Michael Schubert, Jeroen van den Berg, Bastiaan Evers, Anna G Manjón, Stacey Joosten, Yongsoo Kim, Wilbert Zwart, René H Medema
Publikováno v:
Friskes, A, Koob, L, Krenning, L, Severson, T M, Koeleman, E S, Vergara, X, Schubert, M, van den Berg, J, Evers, B, Manjón, A G, Joosten, S, Kim, Y, Zwart, W & Medema, R H 2022, ' Double-strand break toxicity is chromatin context independent ', Nucleic Acids Research, vol. 50, no. 17, pp. 9930-9947 . https://doi.org/10.1093/nar/gkac758
Nucleic Acids Research, 50(17), 9930-9947. Oxford University Press
Nucleic Acids Research, 50(17), 9930-9947. Oxford University Press
Cells respond to double-strand breaks (DSBs) by activating DNA damage response pathways, including cell cycle arrest. We have previously shown that a single double-strand break generated via CRISPR/Cas9 is sufficient to delay cell cycle progression a
Autor:
Lisa Koob, Anoek Friskes, Louise van Bergen, Femke M. Feringa, Bram van den Broek, Emma S. Koeleman, Ellis van Beek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema
Publikováno v:
Molecular Oncology.
Autor:
Lisa Koob, Anoek Friskes, Louise van Bergen, Femke M. Feringa, Bram van den Broek, Emma S. Koeleman, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema
SummaryFaithful and timely repair of DNA double-strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co-factor MND1 facilitates the repair of DSBs in somatic cells. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825552fd1e987eb195830fc54ae0df7c
https://doi.org/10.1101/2022.08.24.505076
https://doi.org/10.1101/2022.08.24.505076
Autor:
Alex von Kriegsheim, Linda Kogerman, Bryan Serrels, Niamh McGivern, Alexander Loftus, Valerie G. Brunton, Billie Georgina Cooper Griffith, Emma S. Koeleman, Graeme R. Grimes, Ana Herrero, John C. Dawson, Jayne Culley, Adam Byron, Margaret C. Frame
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eeb54127bc4b815039464d35ac0fe22
https://doi.org/10.1101/2021.08.31.458428
https://doi.org/10.1101/2021.08.31.458428
Autor:
Adam Byron, Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex von Kriegsheim, Valerie G. Brunton, Margaret C. Frame
Publikováno v:
Byron, A, Griffith, B G C, Herrero, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, Kriegsheim, A V, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications, vol. 13, no. 1, 3053 . https://doi.org/10.1038/s41467-022-30556-5
Byron, A, Griffith, B, Herrero Mier, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, von Kriegsheim, A, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications . https://doi.org/10.1038/s41467-022-30556-5
Byron, A, Griffith, B, Herrero Mier, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, von Kriegsheim, A, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications . https://doi.org/10.1038/s41467-022-30556-5
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localis