A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Autor: Sylvain Lefort, Véronique Maguer-Satta, Thibault Voeltzel, Giulio Menegazzi, Anaëlle Bobard, Léa Barral, Sandrine Jeanpierre, Emma Risson, Laurine Moindrot, Kevin Geistlich, Kawtar Arizkane

Publikováno v: Journal of Visualized Experiments.

The medullary niche is a complex ecosystem that is essential to maintain homeostasis for resident cells. Indeed, the bone marrow, which includes a complex extracellular matrix and various cell types, such as mesenchymal stem cells, osteoblasts, and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d6d1719c1cacbf158f09d45a0cc0fd
https://doi.org/10.3791/64736-v

Bone marrow NG2

Autor: Ana Rita, Nobre, Emma, Risson, Deepak K, Singh, Julie S, Di Martino, Julie F, Cheung, Jiapeng, Wang, John, Johnson, Hege G, Russnes, Jose Javier, Bravo-Cordero, Alexander, Birbrair, Bjorn, Naume, Mohamad, Azhar, Paul S, Frenette, Julio A, Aguirre-Ghiso

Publikováno v: Nature cancer. 2(3)

In the bone marrow (BM) microenvironment, where breast cancer (BC) disseminated tumour cells (DTCs) can remain dormant for decades, NG2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d20e98100d863bf06077545bcd5db15
https://pubmed.ncbi.nlm.nih.gov/34993493

Bone marrow NG2(+)/Nestin(+) mesenchymal stem cells drive DTC dormancy via TGFβ2

Autor: Jose Javier Bravo-Cordero, Jiapeng Wang, Ana Rita Nobre, Alexander Birbrair, Julie Di Martino, John A. Johnson, Paul S. Frenette, Emma Risson, Mohamad Azhar, Bjørn Naume, Hege G. Russnes, Julie F. Cheung, Julio A. Aguirre-Ghiso, Deepak K. Singh

Publikováno v: Nat Cancer

In the bone marrow (BM) microenvironment, where breast cancer (BC)-disseminated tumor cells (DTCs) can remain dormant for decades, NG2+/Nestin+ mesenchymal stem cells (MSCs) promote hematopoietic stem cell quiescence. Here we reveal that periarteriol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fefe542a1e3b91bef74c0cf219ed250
https://europepmc.org/articles/PMC8730384/

Immunology of COVID-19: current state of the science

Autor: Ephraim Kenigsberg, Joan Shang, Jovani Catalan, Tamar Plitt, Dan Fu Ruan, Katherine E. Lindblad, Jamie Redes, Francesca Cossarini, Zeynep H. Gümüş, Maria Casanova-Acebes, Julio A. Aguirre-Ghiso, Nina Bhardwaj, Robert M. Samstein, Venu Pothula, Uri Laserson, Matthew Lin, Erica Dalla, Jeremiah J. Faith, Manasi Agrawal, Alice O. Kamphorst, Ivan Reyes Torres, Luisanna Pia, Monica Centa, Jessica Tan, Brian D. Brown, Jonathan Chung, Graham J. Britton, Miriam Saffern, Assaf Magen, Matthew P. Spindler, Conor Gruber, Saurabh Mehandru, Amir Horowitz, Timothy O'Donnell, Florian Krammer, Jill Gregory, Gabrielle Lubitz, Pauline Hamon, Meriem Belabed, Matthew Brown, Emma Risson, Louise Malle, Emilie K. Grasset, Alfonso R. Sanchez-Paulete, Justine Noel, Zafar Mahmood, Daniel Lozano-Ojalvo, Mark P. Roberto, Julia Kodysh, Verena van der Heide, Evan Cody, Elliot Meritt, Chang Moon, Maria Suprun, Andrew Leader, Bérengère Salomé, Nicolas F. Fernandez, Dusan Bogunovic, Michelle Tran, Nicolas Vabret, Dirk Homann, Miyo Ota, Cansu Cimen Bozkus, Andrew Charap, Divya Jha, Konstantina Alexandropoulos, Etienne Humblin, Benjamin Greenbaum, Maria Kuksin, Gustavo Martinez-Delgado, Andrew K Chan, Myvizhi Esai Selvan, C. Matthias Wilk, Maria A. Curotto de Lafaille, Samarth Hegde, Alessandra Soares Schanoski, Joel Kim, Jaime Mateus-Tique, Alvaro Moreira, John A. Grout, Rachel Levantovsky, Natalie Vaninov, Peter S. Heeger, Mark Aleynick, Matthew D. Park, Judy H. Cho, Miriam Merad, Steven T. Chen

Publikováno v: Immunity

The coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ebe77d2897f47bc85766b7d390b28f
http://europepmc.org/articles/PMC7200337

[The intestinal microbiota, a key modulator of immune physiology]

Autor: Valentine, Boutherin, Florence, Piastra-Facon, Emma, Risson

Publikováno v: Medecine sciences : M/S. 35(6-7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ea338d70f761db3a14468a305b41949
https://pubmed.ncbi.nlm.nih.gov/31274090