Abstract LB221: Novel peptide linker-based nectin-4 targeting ADC shows improved tolerability with long-lasting anti-tumor efficacy at low doses

Autor: Isabella Attinger-Toller, Philipp Probst, Romain Bertrand, Emma Renard, Ramona Stark, Roger Santimaria, Dragan Grabulovski, Bernd Schlereth, Philipp Rene Spycher

Publikováno v: Cancer Research. 83:LB221-LB221

The Araris site-specific and one-step peptide linker conjugation technology generates stable, safe and highly potent ADCs without the need for antibody engineering prior to payload conjugation. We generated an anti-Nectin-4 ADC that shows superior an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d22a936be8d16e275ea2066b946ca1a8
https://doi.org/10.1158/1538-7445.am2023-lb221

Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with 68 Ga-Labeled Antagonists: The Chelate Makes the Difference Again

Autor: Mélanie Guillemin, Pierre-Simon Bellaye, Franck Denat, Aurélie Prignon, Victor Goncalves, Emma Renard, Mathieu Moreau, Bertrand Collin

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (12), pp.8564-8578. ⟨10.1021/acs.jmedchem.1c00523⟩

Neurotensin receptor 1 (NTS1) is involved in the development and progression of numerous cancers, which makes it an interesting target for the development of diagnostic and therapeutic agents. A small molecule NTS1 antagonist, named [177Lu]Lu-IPN0108

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11600a1ea828363b7a3e1a659d0d687
https://hal.archives-ouvertes.fr/hal-03470823

Abstract 1401: Lead optimization of radiopharmaceuticals for molecular radiotherapy and preclinical evaluation

Autor: Emma Renard, Olivier Raguin, Victor Goncalves, Celine Mothes, Mathieu Moreau, Claire Bernhard, Peggy Provent, Frederic Boschetti, Franck Denat, Fabrice Viviani, Cyril Berthet

Publikováno v: Cancer Research. 82:1401-1401

Molecular Radiotherapy (MRT) targeting SSTR2 or PSMA have proven to be highly efficient for the treatment of neuroendocrine or metastatic prostate cancer, respectively. Beyond the leading radiopharmaceutical molecules 177Lu-DOTATATE or 177Lu-PSMA-617

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39b203f4d4cd9bbfebd9d4e96c59bf4e
https://doi.org/10.1158/1538-7445.am2022-1401

Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors

Autor: Franck Denat, Martin Gotthardt, Emma Renard, Estel Collado Camps, Sanne A. M. van Lith, Annemarie Kip, Coline Canovas, Mark Rijpkema, Victor Goncalves

Publikováno v: Cancers
Cancers, MDPI, 2021, 13 (3), pp.428. ⟨10.3390/cancers13030428⟩
Cancers, 13
Cancers, 13, 3
Cancers; Volume 13; Issue 3; Pages: 428
Cancers, Vol 13, Iss 428, p 428 (2021)

Simple Summary Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7dee18e3a2f987aa8556ea09534139
https://hdl.handle.net/2066/230616

PET imaging of neurotensin receptor-positive tumors with 68Ga-labeled antagonists: 'the chelate makes again the difference'

Autor: Victor Goncalves, Mathieu Moreau, Pierre-Simon Bellaye, Franck Denat, Emma Renard

Publikováno v: Nuclear Medicine and Biology. :S6-S7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff34ea422b5e41c1510211271e34da1f
https://doi.org/10.1016/s0969-8051(21)00277-8