Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Emma R. James"'
Autor:
Liina Nagirnaja, Alexandra M. Lopes, Wu-Lin Charng, Brian Miller, Rytis Stakaitis, Ieva Golubickaite, Alexandra Stendahl, Tianpengcheng Luan, Corinna Friedrich, Eisa Mahyari, Eloise Fadial, Laura Kasak, Katinka Vigh-Conrad, Manon S. Oud, Miguel J. Xavier, Samuel R. Cheers, Emma R. James, Jingtao Guo, Timothy G. Jenkins, Antoni Riera-Escamilla, Alberto Barros, Filipa Carvalho, Susana Fernandes, João Gonçalves, Christina A. Gurnett, Niels Jørgensen, Davor Jezek, Emily S. Jungheim, Sabine Kliesch, Robert I. McLachlan, Kenan R. Omurtag, Adrian Pilatz, Jay I. Sandlow, James Smith, Michael L. Eisenberg, James M. Hotaling, Keith A. Jarvi, Margus Punab, Ewa Rajpert-De Meyts, Douglas T. Carrell, Csilla Krausz, Maris Laan, Moira K. O’Bryan, Peter N. Schlegel, Frank Tüttelmann, Joris A. Veltman, Kristian Almstrup, Kenneth I. Aston, Donald F. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The GEMINI consortium sequenced 1,000 cases of idiopathic male infertility and identified a plausible Mendelian cause in 20% of cases. The infertility genes can be grouped by expression pattern, facilitating their interpretation and follow-up.
Externí odkaz:
https://doaj.org/article/d33757f275f346459883626f17daf68f
Autor:
Timothy G. Jenkins, Emma R. James, Kenneth I. Aston, Albert Salas-Huetos, Alexander W. Pastuszak, Ken R. Smith, Heidi A. Hanson, James M. Hotaling, Douglas T. Carrell
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-8 (2019)
Abstract Background The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-define
Externí odkaz:
https://doaj.org/article/c2a6e9ae51154ee19c83b06868000d33
Autor:
Emma R. James, Douglas T. Carrell, Kenneth I. Aston, Timothy G. Jenkins, Marc Yeste, Albert Salas-Huetos
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5377 (2020)
It is well-established that testicular spermatozoa are immature and acquire motility and fertilization capabilities during transit throughout the epididymis. The epididymis is a duct-like organ that connects the testis to the vas deferens and is comp
Externí odkaz:
https://doaj.org/article/9ff74c0322a14adf924e8bff2d00e5cc
Autor:
Magdalena Zernicka-Goetz, Jingtao Guo, Paul Schimmel, Dongmei Tan, Xuemei Chen, Emma R. James, Reuben Franklin, Marta N. Shahbazi, Qi Chen, Qiwei Zhai, Yunfang Zhang, Ying Zhang, Shichao Liu, Kirsty Ml Mackinlay, Xiang-Lei Yang, Bernhard Kuhle, Bradley R. Cairns, Liwen Zhang, Sihem Cheloufi, Douglas T. Carrell, Linlin Zhao, Changcheng Zhou, Yongcun Qu, Wenxin Zhao, Yinsheng Wang, Junchao Shi, Weifeng Gu, Xudong Zhang, Tong Zhou, Jernej Murn, Menghong Yan
Publikováno v:
Nature cell biology, vol 23, iss 4
Nat Cell Biol
Nat Cell Biol
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA library construction protocol generates biased sequencing results. This is partially due to RN
Autor:
Timothy G. Jenkins, Albert Salas-Huetos, Emma R. James, Marc Yeste, Kenneth I. Aston, Douglas T. Carrell
Publikováno v:
Europe PubMed Central
Background The presence of miRNAs in human reproductive tissue is intriguing and suggests the possibility that these important regulatory molecules play a role in reproductive function. However, the regulatory role of miRNAs in reproductive tissue re
Publikováno v:
Reproductive Biology. 19:219-224
Human semen quality has declined worldwide in the last 40 years, by some accounts as much as 50-60%, causing serious concerns and implications for human fertility. Even though it has been shown to be a worldwide problem, this decrease is more pronoun
Autor:
Marc Yeste, Albert Salas-Huetos, Kenneth I. Aston, Nerea Becerra-Tomás, Emma R. James, Jordi Ribas-Maynou
Publikováno v:
Biological reviews of the Cambridge Philosophical SocietyREFERENCES. 96(4)
The clinical effect of sperm DNA damage in assisted reproduction has been a controversial topic during recent decades, leading to a variety of clinical practice recommendations. While the latest European Society of Human Reproduction and Embryology (
Autor:
Ummet Abur, Ahmed Hamed Arisha, Brooke Armistead, Kenneth I. Aston, N.H. Balasinor, Barbara Benassi, Douglas T. Carrell, Shrijeet Chakraborti, Eugenia Cordelli, Kinjal Dave, Sharvari Deshpande, Sascha Drewlo, Anthony R. Gostick, Sezgin Gunes, Nojan Hafizi, Jinlian Hua, John Huntriss, Arif Hussain, Hiroki Ikeda, Emma R. James, Timothy G. Jenkins, Eugenia Johnson, Sadhana Joshi, Shama Prasada Kabekkodu, Leena Kadam, Jyotdeep Kaur, Hisato Kobayashi, Hamid-Reza Kohan-Ghadr, Takeo Kubota, Kazuki Kurimoto, Aatish Mahajan, Sweta Nair, Lakshmi Natarajan, Francesca Pacchierotti, Priyanka Parte, Aniket G. Patankar, Sahar Qazi, Beenish Rahat, Albert Salas-Huetos, Sabita N. Saldanha, Divika Sapehia, Ashok Sharma, Shefina Silas, Isha Singh, Parampal Singh, Madhumitha Kedhari Sundaram, Deepali Sundrani, Padmanaban S. Suresh, Burak Tatar, Shilpa Thakur, Sanu Thankachan, Pinar Tulay, Eva Tvrdá, Thejaswini Venkatesh, Juqing Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8799b0b7f3093cd52572e2e37390765
https://doi.org/10.1016/b978-0-12-819753-0.01002-3
https://doi.org/10.1016/b978-0-12-819753-0.01002-3
Autor:
Albert Salas-Huetos, Emma R. James, Timothy G. Jenkins, Douglas T. Carrell, Kenneth I. Aston, Anthony R. Gostick
The aging process in humans is a known contributor to declining fertility in both sexes. In females, this decline is abrupt and represents a complete barrier to a woman's ability to conceive. In contrast, the impact of aging on male fertility is far
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e343811df65f7ffa87fd6ccaca3c2d
https://doi.org/10.1016/b978-0-12-819753-0.00013-1
https://doi.org/10.1016/b978-0-12-819753-0.00013-1
Autor:
Albert Salas-Huetos, Dallin S. Broberg, Emma R. James, Douglas T. Carrell, Kenneth I. Aston, Timothy G. Jenkins
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
Male aging and obesity have both been shown to contribute to declines in fertility in men. Recent work in aging has shown consistent epigenetic changes to sperm as a man ages. In fact, our lab has built a tool that utilizes DNA methylation signatures