Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Emma R, Wilson"'
Autor:
Ghjuvan'Ghjacumu Shackleford, Leandro N Marziali, Yo Sasaki, Anke Claessens, Cinzia Ferri, Nadav I Weinstock, Alexander M Rossor, Nicholas J Silvestri, Emma R Wilson, Edward Hurley, Grahame J Kidd, Senthilvelan Manohar, Dalian Ding, Richard J Salvi, M Laura Feltri, Maurizio D'Antonio, Lawrence Wrabetz
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010477 (2022)
Myelin is essential for rapid nerve impulse propagation and axon protection. Accordingly, defects in myelination or myelin maintenance lead to secondary axonal damage and subsequent degeneration. Studies utilizing genetic (CNPase-, MAG-, and PLP-null
Externí odkaz:
https://doaj.org/article/3727869bf2534264a552e58bc6edf603
Autor:
Gustavo Della-Flora Nunes, Emma R. Wilson, Leandro N. Marziali, Edward Hurley, Nicholas Silvestri, Bin He, Bert W. O’Malley, Bogdan Beirowski, Yannick Poitelon, Lawrence Wrabetz, M. Laura Feltri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, a
Externí odkaz:
https://doaj.org/article/dee61ba939654c5b97e3ebabed37e14e
Autor:
Gustavo Della-Flora Nunes, Emma R Wilson, Edward Hurley, Bin He, Bert W O'Malley, Yannick Poitelon, Lawrence Wrabetz, M Laura Feltri
Publikováno v:
eLife, Vol 10 (2021)
Schwann cell (SC) mitochondria are quickly emerging as an important regulator of myelin maintenance in the peripheral nervous system (PNS). However, the mechanisms underlying demyelination in the context of mitochondrial dysfunction in the PNS are in
Externí odkaz:
https://doaj.org/article/bab27ff9a3d44321940e8da7640d677e
Autor:
Emma R. Wilson, Umaiyal Kugathasan, Andrey Y. Abramov, Alex J. Clark, David L.H. Bennett, Mary M. Reilly, Linda Greensmith, Bernadett Kalmar
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 1-14 (2018)
Hereditary sensory neuropathy type 1 (HSN-1) is a peripheral neuropathy most frequently caused by mutations in the SPTLC1 or SPTLC2 genes, which code for two subunits of the enzyme serine palmitoyltransferase (SPT). SPT catalyzes the first step of de
Externí odkaz:
https://doaj.org/article/ca04a88aa9f2466d8a8efd2ed27538c5
Autor:
Ghjuvan’Ghjacumu Shackleford, Leandro N. Marziali, Yo Sasaki, Nadav I. Weinstock, Alexander M. Rossor, Nicholas J. Silvestri, Emma R. Wilson, Edward Hurley, Grahame J. Kidd, Senthilvelan Manohar, Dalian Ding, Richard J. Salvi, M. Laura Feltri, Maurizio D’Antonio, Lawrence Wrabetz
Myelin is essential for rapid nerve impulse propagation and axon protection. Accordingly, defects in myelination or myelin maintenance lead to secondary axonal damage and subsequent degeneration. Studies utilizing genetic (CNPase-, MAG-, and PLP-null
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbf50a0d0bcd3a0490fe49db2eeb787e
https://doi.org/10.1101/2022.05.09.491190
https://doi.org/10.1101/2022.05.09.491190
Autor:
Michael R. Weaver, Emma R. Wilson, M. Laura Feltri, Luciana Romina Frick, Gustavo Della-Flora Nunes
Publikováno v:
Dev Neurobiol
Schwann cells play a critical role in the development of the peripheral nervous system, establishing important relationships both with the extracellular milieu and other cell types, particularly neurons. In this review, we discuss various Schwann cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e728d60a97a081dac14733cf61894218
https://doi.org/10.1002/dneu.22744
https://doi.org/10.1002/dneu.22744
Autor:
Lawrence Wrabetz, Bin He, Bogdan Beirowski, Gustavo Della-Flora Nunes, Leandro N. Marziali, Emma R. Wilson, Bert W. O'Malley, Yannick Poitelon, M. Laura Feltri, Edward Hurley, Nicholas Silvestri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
In peripheral nerves, Schwann cells form myelin and provide trophic support to axons. We previously showed that the mitochondrial protein prohibitin 2 can localize to the axon-Schwann-cell interface and is required for developmental myelination. Whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c098be287b2f4d181bfdbc5319e4f5
https://doi.org/10.1038/s41467-021-23552-8
https://doi.org/10.1038/s41467-021-23552-8
Publikováno v:
Journal of anatomy. 241(5)
Recent years have seen an evolving appreciation for the role of glial cells in the nervous system. As we move away from the typical neurocentric view of neuroscience, the complexity and variability of central nervous system glia is emerging, far beyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a22401edff219a1d090325b4e8a991a
https://pubmed.ncbi.nlm.nih.gov/34131911
https://pubmed.ncbi.nlm.nih.gov/34131911
Autor:
Lawrence Wrabetz, Bin He, Maria Laura Feltri, Emma R. Wilson, Della-Flora Nunes G, Bert W. O'Malley, Yannick Poitelon, Edward Hurley
Schwann cell (SC) mitochondria are quickly emerging as an important regulator of myelin maintenance in the peripheral nervous system (PNS). However, the mechanisms underlying demyelination in the context of mitochondrial dysfunction in the PNS are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41a1084e09df4974bcf9e6a24ebb9f60
https://doi.org/10.1101/2020.11.25.398032
https://doi.org/10.1101/2020.11.25.398032
Autor:
Georgios Baskozos, Matilde Laura, Nadine Fugger, Alex J. Clark, Iulia Blesneac, David L.H. Bennett, Thorsten Hornemann, Emma R. Wilson, Ka Hing Chu, Mary M. Reilly, Alaa Othman, U Kugathasan, Museer A. Lone, David A. Priestman, Frances M. Platt, Bernadett Kalmar, Linda Greensmith
Publikováno v:
Cell Reports Medicine
Summary Hereditary sensory neuropathy type 1 (HSN1) is caused by mutations in the SPTLC1 or SPTLC2 sub-units of the enzyme serine palmitoyltransferase, resulting in the production of toxic 1-deoxysphingolipid bases (DSBs). We used induced pluripotent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928f832674554a7428acbfb0017e9219
https://pubmed.ncbi.nlm.nih.gov/34337561
https://pubmed.ncbi.nlm.nih.gov/34337561