Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Emma P. Danhash"'
Autor:
Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan, Mathew Blurton-Jones
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering receptor expressed on
Externí odkaz:
https://doaj.org/article/c0e75e997897499ba66b3c9ec6115f97
Autor:
Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110961- (2022)
Summary: Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetica
Externí odkaz:
https://doaj.org/article/def9c689b7ba47e59182ba5cb0a6929b
Autor:
Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan
Publikováno v:
Alzheimer's & Dementia. 18:1765-1778
The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on microglial responses to AD pathology remains unknown. Chimeric AD and wild-type mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463825c6c305b25a2f0c80da82f03755
https://doi.org/10.1002/alz.12577
https://doi.org/10.1002/alz.12577