Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology

Autor: Rebecca L. Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A. Gifford, Kimberly R. Pechman, Mabel Seto, Vladislav A. Petyuk, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman, the Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)

Abstract Recent evidence suggests that Alzheimer’s disease (AD) genetic risk variants (rs1582763 and rs6591561) of the MS4A locus are genome-wide significant regulators of soluble TREM2 levels such that the minor allele of the protective variant (r

Externí odkaz: https://doaj.org/article/7f931778e48b4a1db9dee9d86d867c84

Parental physical activity, parental mental health, children’s physical activity, and children’s mental health

Autor: Gavin Davidson, Lisa Bunting, Claire McCartan, Anne Grant, Orla McBride, Ciaran Mulholland, Emma Nolan, Dirk Schubotz, Julie Cameron, Mark Shevlin

Publikováno v: Frontiers in Psychiatry, Vol 15 (2024)

IntroductionThe benefits of physical activity for mental health and well-being and the associations between parental mental health and children’s mental health have been well established. These important issues tend to be examined separately howeve

Externí odkaz: https://doaj.org/article/e2e366ed1d9240b7abe39c115215234b

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

Autor: Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer

Publikováno v: Haematologica, Vol 107, Iss 2 (2020)

There is a strong biological rationale for the augmentation of allogeneic natural killer (NK) cell therapies with a chimeric antigen receptor (CAR) to enhance acute myeloid leukemia (AML) targeting. CD38 is an established immunotherapeutic target in

Externí odkaz: https://doaj.org/article/b0166d6551d14cd29eee673fac8c0c91

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

Autor: Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M. Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H. Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V. Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimiliano Mazzone, Sara Zanivan, Jan Cools, Hans Wildiers, Véronique Baud, Thomas G. P. Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt

Publikováno v: Nature Cancer. 4:344-364

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85210a0de8bfe20db9c7f08ff695b2a0
https://doi.org/10.1038/s43018-023-00513-2

Prevalence and risk factors of mood and anxiety disorders in children and young people: Findings from the Northern Ireland Youth Wellbeing Survey

Autor: Lisa Bunting, Emma Nolan, Claire McCartan, Gavin Davidson, Anne Grant, Ciaran Mulholland, Dirk Schubotz, Orla McBride, Jamie Murphy, Mark Shevlin

Publikováno v: Bunting, L, Nolan, E, McCartan, C, Davidson, G, Grant, A, Mulholland, C, Schubotz, D, McBride, O, Murphy, J & Shevlin, M 2022, ' Prevalence and Risk Factors of Mood and Anxiety Disorders in Children and Young People: Findings from the Northern Ireland Youth Wellbeing Survey ', Clinical Child Psychology and Psychiatry, vol. 27, no. 3, pp. 686-700 . https://doi.org/10.1177/13591045221089841

Objective: This paper presents the key findings from the Northern Ireland Youth Wellbeing Prevalence Survey (NIYWS), specifically the prevalence of common mental health disorders and their association with personal, familial and socio-economic risk f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310a2a769d373390d1842357fc2f0e2
https://doi.org/10.1177/13591045221089841