Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Emma Morrish"'
Autor:
Christoph Grohmann, Charlene M. Magtoto, Joel R. Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A. Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S. Simpson, Hao Dong, Bridget Dorizzi, Annette V. Jacobsen, Emma Morrish, Natasha Silke, James M. Murphy, Joan K. Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume Lessene, John Silke, Rebecca Feltham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
tag-Targeted Protein Degrader (tTPD) systems are powerful tools for preclinical target validation. Here the authors extend the tTPD platform by developing NanoTACs that degrade NanoLuc tagged substrates and benchmark each tTPD system using an interch
Externí odkaz:
https://doaj.org/article/cbe3c5d3eff94f2bbdf917175c5d3791
Autor:
Emma Morrish, Jürgen Ruland
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/0cf8760f41e74abb8651959368b411ec
Autor:
Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert
Publikováno v:
Viruses, Vol 12, Iss 8, p 901 (2020)
Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecule compounds that mimic natural antagonists of inhibitor of apoptosis (IAP) proteins, known as Smac-mimetics (second mito
Externí odkaz:
https://doaj.org/article/7539cde5a1dd4d14aa1973938e0299db
Publikováno v:
Cells, Vol 9, Iss 2, p 406 (2020)
It is well accepted that the ability of cancer cells to circumvent the cell death program that untransformed cells are subject to helps promote tumor growth. Strategies designed to reinstate the cell death program in cancer cells have therefore been
Externí odkaz:
https://doaj.org/article/409ecd0ba5354ab998fdd451c56dff83
Publikováno v:
European Journal of Immunology
VAV1-MYO1F is a recently identified gain-of-function (GOF) fusion protein of the proto-oncogene Vav guanine nucleotide exchange factor 1 (VAV1) that is recurrently detected in T-cell Non-Hodgkin's lymphoma (T-NHL) patients. However, the pathophysiolo
Autor:
Lin Liu, Jarrod J. Sandow, Deena M. Leslie Pedrioli, Andre L. Samson, Natasha Silke, Tobias Kratina, Rebecca L. Ambrose, Marcel Doerflinger, Zhaoqing Hu, Emma Morrish, Diep Chau, Andrew J. Kueh, Cheree Fitzibbon, Marc Pellegrini, Jaclyn S. Pearson, Michael O. Hottiger, Andrew I. Webb, Najoua Lalaoui, John Silke
Publikováno v:
Science advances. 8(19)
Tumor necrosis factor (TNF) is a key component of the innate immune response. Upon binding to its receptor, TNFR1, it promotes production of other cytokines via a membrane-bound complex 1 or induces cell death via a cytosolic complex 2. To understand
Autor:
Emma, Morrish, Jürgen, Ruland
Publikováno v:
Nature
Cellular transformation induces phenotypically diverse populations of tumor-infiltrating T cells(1, 2, 3, 4, 5), and immune checkpoint blockade therapies preferentially target T cells that recognize cancer cell neoantigens(6, 7). Yet, how other class
Autor:
Leslie Pedrioli Dm, Michael O. Hottiger, Andrew J. Kueh, Jarrod J. Sandow, Hu Z, Andrew I. Webb, John Silke, Emma Morrish, Diep Chau, Lin Liu, Tobias Kratina, Najoua Lalaoui, Natasha Silke
Tumor necrosis factor (TNF) is an inflammatory cytokine that, upon binding to its receptor TNFR1, can drive cytokine production, cell survival, or cell death and is a major component of an organism’s anti-pathogen repetoire1,2. TNF stimulation lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e871d0dd48a1dc05a174b244f2b7e28
https://doi.org/10.1101/2021.02.09.430424
https://doi.org/10.1101/2021.02.09.430424
Autor:
Seong Lin Khaw, Nadia May Davidson, Ricky W. Johnstone, Gabriela Brumatti, Paul G Ekert, Stefan Bjelosevic, Hansen J. Kosasih, Margs S. Brennan, Emma Morrish, Alicia Oshlack
Publikováno v:
Blood Adv
Key Points A novel KMT2A-rearrangement, MLL-TFE3, was identified in an infant leukemia patient. MLL-TFE3 expression produces aggressive leukemia in a mouse model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbd94b2818e2154b7cb001e34b331e1
https://europepmc.org/articles/PMC7556123/
https://europepmc.org/articles/PMC7556123/
Autor:
Marc Pellegrini, Gabriela Brumatti, Gregor Ebert, Liana Mackiewicz, John Silke, Emma Morrish, Natasha Silke
Publikováno v:
Viruses
Volume 12
Issue 8
Viruses, Vol 12, Iss 901, p 901 (2020)
Volume 12
Issue 8
Viruses, Vol 12, Iss 901, p 901 (2020)
Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecule compounds that mimic natural antagonists of inhibitor of apoptosis (IAP) proteins, known as Smac-mimetics (second mito