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A Potential Mechanism for Targeting Aggregates With Proteasomes and Disaggregases in Liquid Droplets
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Insoluble protein deposits are hallmarks of neurodegenerative disorders and common forms of dementia. The aberrant aggregation of misfolded proteins involves a complex cascade of events that occur over time, from the cellular to the clinical phase of
Externí odkaz:
https://doaj.org/article/3e758ca14abf468ea621bf54edf37399
Autor:
Michael J. Morten, Liina Sirvio, Huzefa Rupawala, Emma Mee Hayes, Aitor Franco, Carola Radulescu, Liming Ying, Samuel J. Barnes, Arturo Muga, Yu Ye
Protein aggregation is a hallmark of major neurodegenerative disorders. Increasing data suggest that smaller aggregates cause higher toxic response than filamentous aggregates (fibrils). However, the size of small aggregates has challenged their dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca2ffcea7d7251652f565092d2ac05d
http://hdl.handle.net/10044/1/100274
http://hdl.handle.net/10044/1/100274
Autor:
Ece Kocagoncu, Kanisa Arunasalam, Jennifer Lawson, Ivan Koychev, Paresh Malhotra, James B. Rowe, Tharani Chessell, Emma Mee Hayes, Zameel M. Cader, Richard Wade-Martins, Basil H. Ridha, Elena M. Ribe, Bryan Ng, Tina Wei, Noel J. Buckley, Helen Rowland, Anne Hedegaard, Alan J. Thomas, Roger N. Gunn, Dominic Ffytche, Dennis Chan, Giovanna Zamboni, Simon Lovestone
Establishing preclinical models of Alzheimer’s disease that predict clinical outcomes remains a critically important, yet to date not fully realised, goal. Models derived from human cells offer considerable advantages over non-human models, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a843909c7338de3e23ecd1b56df8fa9
https://doi.org/10.1101/2021.11.09.467891
https://doi.org/10.1101/2021.11.09.467891