Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Emma McIver"'
Autor:
Jana Gillies, Qing Huang, Isaac Rosado-Sánchez, Emma McIver, Paul C. Orban, Megan K. Levings, Madeleine Speck, Nicholas A.J. Dawson, Grace Sun, Vivian C.W. Fung, Majid Mojibian, German E. Novakovsky
Publikováno v:
Science translational medicine. 12(557)
Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors (CARs) are a potent immunosuppressive cellular therapy in multiple disease models and could overcome shortcomings of polyclonal Treg therapy. CAR therapy was initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccbc306d3720bbc94f5483c54cdf8b1
https://pubmed.ncbi.nlm.nih.gov/32817364
https://pubmed.ncbi.nlm.nih.gov/32817364
Autor:
Megan K. Levings, Madeleine Speck, Nicholas A.J. Dawson, Vivian C.W. Fung, German E. Novakovsky, Emma McIver, Majid Mojibian, Qing Huang, Grace Sun, Paul C. Orban, Jana Gillies, Isaac Rosado-Sánchez
SummaryAntigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptor (CARs) are a potent immunosuppressive cellular therapy in multiple disease models. To date the majority of CAR Treg studies employed second generation CARs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c0cd89dea68b3e90cc07b5f8030a8f
Autor:
Jonathan W. Bush, Jana Gillies, Madeleine Speck, Qing Huang, Megan K. Levings, Romy E. Hoeppli, Nicholas A.J. Dawson, Paul C. Orban, Caroline Lamarche, Emma McIver, Peter Bergqvist, Vivian C.W. Fung, Majid Mojibian
Publikováno v:
JCI Insight.
Chimeric antigen receptor (CAR) technology can be used to engineer the antigen specificity of regulatory T cells (Tregs) and improve their potency as an adoptive cell therapy in multiple disease models. As synthetic receptors, CARs carry the risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4c7e638a5ec8196a5d0aa00c27312f
https://doi.org/10.1172/jci.insight.123672
https://doi.org/10.1172/jci.insight.123672