Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Emma M. McErlean"'
Autor:
Emma M. McErlean, Helen O. McCarthy
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-28 (2024)
Abstract Natural Killer (NK) cells are exciting candidates for cancer immunotherapy with potent innate cytotoxicity and distinct advantages over T cells for Chimeric Antigen Receptor (CAR) therapy. Concerns regarding the safety, cost, and scalability
Externí odkaz:
https://doaj.org/article/b2e42061d55e4d1e9ba4d72fcbae4d03
Autor:
Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy
Publikováno v:
Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or
Externí odkaz:
https://doaj.org/article/9ed2bf465afb41bba08a79b15b46f23a
Autor:
Lynn N Jena, Lindsey A Bennie, Emma M McErlean, Sreekanth Pentlavalli, Kim Glass, James F Burrows, Vicky L Kett, Niamh E Buckley, Jonathan A Coulter, Nicholas J Dunne, Helen O McCarthy
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-BPs) have demonstrated direct ant
Externí odkaz:
https://doaj.org/article/ff00e18b61e540388dddf96e6bc47180
Publikováno v:
EJ, M, EM, M, N, D & HO, M 2021, ' A Peptide/MicroRNA-31 Nanomedicine within an Electrospun Biomaterial Designed to Regenerate Wounds In Vivo ', Acta Biomaterialia . https://doi.org/10.1016/j.actbio.2021.11.016
microRNA-31 (miR-31) has been identified to be downregulated in pathologies associated with delayed wound repair. Thus, it was proposed that the delivery of a plasmid encoding miR-31 (pmiR-31) to the skin could hold potential in promoting wound heali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5063ac6f59ff3eec69ada6fa29a3901a
https://doi.org/10.1016/j.actbio.2021.11.016
https://doi.org/10.1016/j.actbio.2021.11.016
Autor:
Eoghan J. Mulholland, Monika Ziminska, Tracy Robson, Grace Cole, Vicky L. Kett, Helen O. McCarthy, Emma M. McErlean, Nicholas Dunne, Cian M. McCrudden, Niamh E. Buckley, John W. McBride, Stephen P. Loughran
Publikováno v:
McErlean, E M, Ziminska, M, McCrudden, C M, McBride, J W, Loughran, S P, Cole, G, Mulholland, E J, Kett, V, Buckley, N E, Robson, T, Dunne, N J & McCarthy, H O 2020, ' Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery ', Journal of Controlled Release, vol. 330, pp. 1288 . https://doi.org/10.1016/j.jconrel.2020.11.037
The design of a non-viral gene delivery system that can release a functional nucleic acid at the intracellular destination site is an exciting but also challenging proposition. The ideal gene delivery vector must be non-toxic, non-immunogenic, overco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f03a6e561e7b2be5887b475b411cf9e
https://doi.org/10.1016/j.jconrel.2020.11.037
https://doi.org/10.1016/j.jconrel.2020.11.037
Autor:
Kristine C.Y. McGrath, Abdelrahim Alqudah, Helen O. McCarthy, Nabila Morshed, Emma M. McErlean, Tracy Robson, Claire Rennie, Ross McNally, Lana McClements, Olga Shimoni, Amy Short
Publikováno v:
Nanomedicine (London, England). 16(22)
Background: Overexpression of sFlt-1 or modulation of FKBPL, key antiangiogenic proteins, are important in the pathogenesis of preeclampsia. Methods: A newly developed nonviral gene-delivery system, RALA, capable of overexpressing sFlt-1 (e15a isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e386bf0b2c370b18580edf883d52d295
https://pubmed.ncbi.nlm.nih.gov/34435509
https://pubmed.ncbi.nlm.nih.gov/34435509
Autor:
Cian M. McCrudden, Emma M. McErlean, Ryan F. Donnelly, Vicky L. Kett, Tracy Robson, Amy Short, Ahlam A. Ali, Joanne McCaffrey, Grace Cole, Eoghan J. Mulholland, Helen O. McCarthy, Nicholas Dunne, Jonathan A. Coulter
Publikováno v:
Cole, G, Ali, A A, McErlean, E, Mulholland, E J, Short, A, McCrudden, C M, McCaffrey, J, Robson, T, Kett, V L, Coulter, J A, Dunne, N J, Donnelly, R F & McCarthy, H O 2019, ' DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen ', Acta Biomaterialia, vol. 96, pp. 480 . https://doi.org/10.1016/j.actbio.2019.07.003
Castrate resistant prostate cancer (CRPC) remains a major challenge for healthcare professionals. Immunotherapeutic approaches, including DNA vaccination, hold the potential to harness the host's own immune system to mount a cell-mediated, anti-tumou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e07b42cca780169c2d602a665e4ce2e
https://doi.org/10.1016/j.actbio.2019.07.003
https://doi.org/10.1016/j.actbio.2019.07.003
Autor:
Jonathan A. Coulter, Lynn Jena, Sreekanth Pentlavalli, Kim Glass, Emma M. McErlean, Vicky L. Kett, James F Burrows, Helen O. McCarthy, Nicholas Dunne, Niamh E. Buckley, Lindsey A. Bennie
Publikováno v:
Jena, L N, Bennie, L A, McErlean, E M, Pentlavalli, S, Glass, K, Burrows, J F, Kett, V L, Buckley, N E, Coulter, J A, Dunne, N J & McCarthy, H O 2021, ' Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme ', Journal of nanobiotechnology, vol. 19, no. 1, pp. 127 . https://doi.org/10.1186/s12951-021-00856-x
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Journal of Nanobiotechnology
Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-BPs) have demonstrated direct anticancer e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fd62a8397daa946dc9e10610f5beba
https://pure.qub.ac.uk/en/publications/149b5aea-d54e-4114-aa43-e4f5d6a59842
https://pure.qub.ac.uk/en/publications/149b5aea-d54e-4114-aa43-e4f5d6a59842
Autor:
Nicholas Dunne, Vicky L. Kett, Emma M. McErlean, John W. McBride, Helen O. McCarthy, Grace Cole, Tracy Robson, Cian M. McCrudden
Publikováno v:
McErlean, E M, McCrudden, C M, McBride, J W, Cole, G, Kett, V L, Robson, T, Dunne, N J & McCarthy, H O 2021, ' Rational design and characterisation of an amphipathic cell penetrating peptide for non-viral gene delivery ', International Journal of Pharmaceutics, vol. 596, 120223 . https://doi.org/10.1016/j.ijpharm.2021.120223
RALA is a cationic amphipathic peptide which has shown great promise as an efficient, multifunctional delivery system for the delivery of nucleic acids. Rational peptide design was utilised in this study to understand the essential amino acids requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310944210b5710bbba2c12c7f036ad05
https://pure.qub.ac.uk/en/publications/5c53cc9b-589a-4890-9376-eff2d5754056
https://pure.qub.ac.uk/en/publications/5c53cc9b-589a-4890-9376-eff2d5754056
Publikováno v:
International journal of pharmaceutics. 598
The electrospinning of polymers has previously shown excellent potential for localised gene therapy. Thus, it was proposed that for the first time, the cell-penetrating CHAT peptide could be utilised to deliver DNA via electrospun nanofibres for loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005f15d7eb6bfee1e4e76e31ced51355
https://pubmed.ncbi.nlm.nih.gov/33561501
https://pubmed.ncbi.nlm.nih.gov/33561501