Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Emma M. Large"'
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Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration
Autor: Emma M. Large, Ujjal Sarkar, John S. Wishnok, Nicholas A. Cilfone, CL Stokes, Douglas A. Lauffenburger, Linda G. Griffith, Jiajie Yu, Steven R. Tannenbaum, Murat Cirit, David J. Hughes
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
Nature
Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm. Success will require quantitative charac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a61cffa11cf4a10b0a648e9f766e39
http://europepmc.org/articles/PMC4625863
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2
Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins
Autor: Christopher E. Goldring, Mohsen Shaeri, Kevin Park, Tomasz Kostrzewski, David Hughes, Rowena Sison-Young, Cliff Rowe, Terri Cornforth, Emma M. Large, Angela Robinson
Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 46
Hepatotoxins cause liver damage via many mechanisms but the formation of reactive metabolites and/or damage to liver mitochondria are commonly implicated. We assess 3D human primary hepatocyte microtissues as a platform for hepatotoxicity studies wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39dde87e6f3c7b934e0074c6b9cd03a9
https://pubmed.ncbi.nlm.nih.gov/28919358
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3
Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk
Autor: Wen L.K. Chen, Collin Edington, Emily Suter, Jiajie Yu, Jeremy J. Velazquez, Jason G. Velazquez, Michael Shockley, Emma M. Large, Raman Venkataramanan, David J. Hughes, Cynthia L. Stokes, David L. Trumper, Rebecca L. Carrier, Murat Cirit, Linda G. Griffith, Douglas A. Lauffenburger
Publikováno v: Wiley
Biotechnology and Bioengineering
A capability for analyzing complex cellular communication among tissues is important in drug discovery and development, and in vitro technologies for doing so are required for human applications. A prominent instance is communication between the gut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0deba83830eea03a51957a7816ae8fd
https://orcid.org/0000-0002-0050-989X
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4
Three-dimensional perfused human
Autor: Tomasz, Kostrzewski, Terri, Cornforth, Sophie A, Snow, Larissa, Ouro-Gnao, Cliff, Rowe, Emma M, Large, David J, Hughes
Publikováno v: World Journal of Gastroenterology
AIM To develop a human in vitro model of non-alcoholic fatty liver disease (NAFLD), utilising primary hepatocytes cultured in a three-dimensional (3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the ef
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96884237ed6ef42e5b0a52f2c7ec79f3
https://pubmed.ncbi.nlm.nih.gov/28127194
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7
Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor
Autor: Steven R. Tannenbaum, Mohammad R. Ebrahimkhani, David Hughes, Kodihalli C. Ravindra, Dinelia Rivera-Burgos, Ujjal Sarkar, Rachel L. Dyer, Linda G. Griffith, John S. Wishnok, Emma M. Large
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 43(7)
Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects on drug metabolism. We have devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b790795da69c0b6567d6961b9e69ee
https://pubmed.ncbi.nlm.nih.gov/25926431
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8
Akademický článek
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease.
Autor: Kostrzewski T; Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom., Cornforth T; Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom., Snow SA; Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom., Ouro-Gnao L; Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom., Rowe C; Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom., Large EM; Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom., Hughes DJ; Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom.
Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2017 Jan 14; Vol. 23 (2), pp. 204-215.
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