Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emma M, Perkins"'
Autor:
Emma M. Perkins, Karen Burr, Poulomi Banerjee, Arpan R. Mehta, Owen Dando, Bhuvaneish T. Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M. Henstridge, Thomas H. Gillingwater, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran, Matthew R. Livesey
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Abstract Background Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 re
Externí odkaz:
https://doaj.org/article/42ab8bf0a50247d5a329f4bef1e411b0
Autor:
Poulomi Banerjee, Evdokia Paza, Emma M. Perkins, Owen G. James, Boyd Kenkhuis, Amy F. Lloyd, Karen Burr, David Story, Dilmurat Yusuf, Xin He, Rolf Backofen, Owen Dando, Siddharthan Chandran, Josef Priller
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102046- (2020)
Microglia are resident tissue macrophages of the central nervous system (CNS) that arise from erythromyeloid progenitors during embryonic development. They play essential roles in CNS development, homeostasis and response to disease. Since microglia
Externí odkaz:
https://doaj.org/article/75a1c32453264622874ece5ccb8fa4a8
Autor:
Bhuvaneish T. Selvaraj, Matthew R. Livesey, Chen Zhao, Jenna M. Gregory, Owain T. James, Elaine M. Cleary, Amit K. Chouhan, Angus B. Gane, Emma M. Perkins, Owen Dando, Simon G. Lillico, Youn-Bok Lee, Agnes L. Nishimura, Urjana Poreci, Sai Thankamony, Meryll Pray, Navneet A. Vasistha, Dario Magnani, Shyamanga Borooah, Karen Burr, David Story, Alexander McCampbell, Christopher E. Shaw, Peter C. Kind, Timothy J. Aitman, C. Bruce A. Whitelaw, Ian Wilmut, Colin Smith, Gareth B. Miles, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Repeat expansion mutation in C9ORF72 is the most common cause of familial ALS. Here, the authors generate motor neurons from cells of patients with C9ORF72 mutations, and characterize changes in gene expression in these motor neurons compared to gene
Externí odkaz:
https://doaj.org/article/6a962a5b03a74471945829a86138ad2f
Autor:
S Chandran, Owain T. James, David J. A. Wyllie, Emma M. Perkins, Matthew R. Livesey, Chen Zhao, C Rosanne M Ausems, Jenna M. Gregory, Alessandra Cardinali, Bhuvaneish T. Selvaraj, Karen Burr, Dario Magnani, Samantha K. Barton, Giles E. Hardingham, Owen G. James, Nicholas M. Morton, Roderick N. Carter, Elaine M. Cleary, David Story, Navneet A. Vasistha
Publikováno v:
Barton, S K, Magnani, D, James, O G, Livesey, M R, Selvaraj, B T, James, O T, Perkins, E M, Gregory, J M, Cleary, E, Ausems, C R M, Carter, R, Vasistha, N A, Zhao, C, Burr, K, Story, D, Cardinali, A, Morton, N M, Hardingham, G E, Wyllie, D J A & Chandran, S 2021, ' TDP-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model ', Brain Communications, vol. 3, no. 4, fcab255 . https://doi.org/10.1093/braincomms/fcab255
Oligodendrocytes are implicated in amyotrophic lateral sclerosis pathogenesis and display transactive response DNA-binding protein-43 (TDP-43) pathological inclusions. To investigate the cell autonomous consequences of TDP-43 mutations on human oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d6d6e844edbdfe4e1fb94d4ced1ab0
https://www.pure.ed.ac.uk/ws/files/260345909/fcab255.pdf
https://www.pure.ed.ac.uk/ws/files/260345909/fcab255.pdf
Autor:
Samantha K, Barton, Dario, Magnani, Owen G, James, Matthew R, Livesey, Bhuvaneish T, Selvaraj, Owain T, James, Emma M, Perkins, Jenna M, Gregory, Elaine, Cleary, C Rosanne M, Ausems, Roderick N Carter, Carter, Navneet A, Vasistha, Chen, Zhao, Karen, Burr, David, Story, Alessandra, Cardinali, Nicholas M, Morton, Giles E, Hardingham, David J A, Wyllie, Siddharthan, Chandran
Publikováno v:
Brain communications. 3(4)
Oligodendrocytes are implicated in amyotrophic lateral sclerosis pathogenesis and display transactive response DNA-binding protein-43 (TDP-43) pathological inclusions. To investigate the cell autonomous consequences of TDP-43 mutations on human oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be225b964161921cf514033eac123830
https://pubmed.ncbi.nlm.nih.gov/35350711
https://pubmed.ncbi.nlm.nih.gov/35350711
Autor:
Amy F. Lloyd, Emma M. Perkins, Josef Priller, Boyd Kenkhuis, David Story, Siddharthan Chandran, Owen Dando, Xin He, Evdokia Paza, Karen Burr, Poulomi Banerjee, Owen G. James, Rolf Backofen, Dilmurat Yusuf
Publikováno v:
Banerjee, P, Paza, E, Perkins, E M, James, O G, Kenkhuis, B, Lloyd, A F, Burr, K, Story, D, Yusuf, D, He, X, Backofen, R, Dando, O, Chandran, S & Priller, J 2020, ' Generation of pure monocultures of human microglia-like cells from induced pluripotent stem cells ', Stem Cell Research, vol. 49, 102046 . https://doi.org/10.1016/j.scr.2020.102046
Stem Cell Research, Vol 49, Iss, Pp 102046-(2020)
Stem cell research 49, 102046 (2020). doi:10.1016/j.scr.2020.102046
Stem Cell Research, Vol 49, Iss, Pp 102046-(2020)
Stem cell research 49, 102046 (2020). doi:10.1016/j.scr.2020.102046
Microglia are resident tissue macrophages of the central nervous system (CNS) that arise from erythromyeloid progenitors during embryonic development. They play essential roles in CNS development, homeostasis and response to disease. Since microglia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a7ad277ce5fb4e57e907ecbb752ab1
https://hdl.handle.net/20.500.11820/7748dc54-e64d-44b4-83b4-f2fdf94e8e60
https://hdl.handle.net/20.500.11820/7748dc54-e64d-44b4-83b4-f2fdf94e8e60
Autor:
Alexander S. Brown, Jessica Magri, Sharan Paul, Anthony E. Oro, Daniel R. Scoles, Thomas S. Otis, Emma M. Perkins, Stefan M. Pulst, Scott X. Atwood, Ravi Chopra, Banu Altindag, Vikram G. Shakkottai, Pratap Meera, Eric Tarapore, Haoran Huang, Mandy Jackson
Publikováno v:
Brown, A S, Meera, P, Altindag, B, Chopra, R, Perkins, E, Paul, S, Scoles, D R, Tarapore, E, Magri, J, Huang, H, Jackson, M, Shakkottai, V G, Otis, T S, Pulst, S M, Atwood, S X & Oro, A E 2018, ' MTSS1/Src family kinase Dysregulation Underlies Multiple Inherited Ataxias ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1816177115
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 52
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 52
The genetically heterogeneous spinocerebellar ataxias (SCAs) are caused by Purkinje neuron dysfunction and degeneration, but their underlying pathological mechanisms remain elusive. The Src family of nonreceptor tyrosine kinases (SFK) are essential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca3cd6d62a687b79f5d1f81f40737fb
https://pubmed.ncbi.nlm.nih.gov/30530649
https://pubmed.ncbi.nlm.nih.gov/30530649
Autor:
Emma M, Perkins, Yvonne L, Clarkson, Daumante, Suminaite, Alastair R, Lyndon, Kohichi, Tanaka, Jeffrey D, Rothstein, Paul A, Skehel, David J A, Wyllie, Mandy, Jackson
Publikováno v:
Human Molecular Genetics
Loss of excitatory amino acid transporters (EAATs) has been implicated in a number of human diseases including spinocerebellar ataxias, Alzhiemer’s disease and motor neuron disease. EAAT4 and GLAST/EAAT1 are the two predominant EAATs responsible fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1767c529549a9984ad231ecc9273757e
https://pubmed.ncbi.nlm.nih.gov/29741614
https://pubmed.ncbi.nlm.nih.gov/29741614
Autor:
Emma M, Perkins, Daumante, Suminaite, Yvonne L, Clarkson, Sin Kwan, Lee, Alastair R, Lyndon, Jeffrey D, Rothstein, David J A, Wyllie, Kohichi, Tanaka, Mandy, Jackson
Publikováno v:
Human Molecular Genetics
Clinical phenotypes of spinocerebellar ataxia type-5 (SCA5) and spectrin-associated autosomal recessive cerebellar ataxia type-1 (SPARCA1) are mirrored in mice lacking β-III spectrin (β-III-/-). One function of β-III spectrin is the stabilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b6e3821c51f0e3c4dcb8af2ad366a4a
https://pubmed.ncbi.nlm.nih.gov/28173092
https://pubmed.ncbi.nlm.nih.gov/28173092
Autor:
Emma M. Perkins, Philip M. Larkman
Publikováno v:
European Journal of Neuroscience. 21:679-691
A 'leak' potassium (K + ) conductance (gK L e a k ) modulated by amine neurotransmitters is a major determinant of neonatal rat facial motoneuron excitability. Although the molecular identity of gK L e a k is unknown, TASK-1 and TASK-3 channel mRNA i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::078d6a11032ad6bb069a1606fcdd507c
https://doi.org/10.1111/j.1460-9568.2005.03898.x
https://doi.org/10.1111/j.1460-9568.2005.03898.x