Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Emma M, Lessieur"'
Autor:
Aicha Saadane, Alexander A. Veenstra, Martin S. Minns, Jie Tang, Yunpeng Du, Fatima Abubakr Elghazali, Emma M. Lessieur, Eric Pearlman, Timothy S. Kern
Publikováno v:
Diabetologia, vol 66, iss 3
Aims/hypothesis Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy. However, the role of monocytes has yet to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37ebefc3bdecc1937775e321167c7cd
https://doi.org/10.1007/s00125-022-05860-w
https://doi.org/10.1007/s00125-022-05860-w
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238727 (2020)
PurposeFemale mice have been found to be resistant to streptozotocin (STZ)-induced diabetes, and pre-clinical research related to diabetic complications commonly omits females. The purpose of this study was to develop a method to induce diabetes in f
Externí odkaz:
https://doaj.org/article/1a0d1aec47344c88ac9990711886ffcf
Autor:
Michelle A. Cruz, Dillon Bohinc, Elizabeth A. Andraska, Jurgis Alvikas, Shruti Raghunathan, Nicole A. Masters, Nadine D. van Kleef, Kara L. Bane, Kathryn Hart, Kathryn Medrow, Michael Sun, Haitao Liu, Shannon Haldeman, Ankush Banerjee, Emma M. Lessieur, Kara Hageman, Agharnan Gandhi, Maria de la Fuente, Marvin T. Nieman, Timothy S. Kern, Coen Maas, Steven de Maat, Keith B. Neeves, Matthew D. Neal, Anirban Sen Gupta, Evi X. Stavrou
Publikováno v:
Nature nanotechnology, vol 17, iss 9
Nat Nanotechnol
Nat Nanotechnol
Targeted drug delivery to disease-associated activated neutrophils can provide novel therapeutic opportunities while avoiding systemic effects on immune functions. We created a nanomedicine platform that uniquely utilizes an α(1)-antitrypsin-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c831df7b71934cc4f40ea9c29b8cba2
https://doi.org/10.1038/s41565-022-01161-w
https://doi.org/10.1038/s41565-022-01161-w
Autor:
Emma M Lessieur, Ping Song, Gabrielle C Nivar, Ellen M Piccillo, Joseph Fogerty, Richard Rozic, Brian D Perkins
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0213960 (2019)
Mutations in the gene Centrosomal Protein 290 kDa (CEP290) result in multiple ciliopathies ranging from the neonatal lethal disorder Meckel-Gruber Syndrome to multi-systemic disorders such as Joubert Syndrome and Bardet-Biedl Syndrome to nonsyndromic
Externí odkaz:
https://doaj.org/article/10739b616cc64662ac51b321bba3452a
Autor:
Jennings C. Luu, Aicha Saadane, Henri Leinonen, Elliot H. Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L. Sander, Arum Wu, Jacob M. Wang, Rupesh Singh, Songqi Gao, Emma M. Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F. Mullins, Neal S. Peachey, Philip D. Kiser, Marcin Tabaka, Timothy S. Kern, Krzysztof Palczewski
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Chronic, progressive retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa, arise from genetic and environmental perturbations of cellular and tissue homeostasis. These disruptions accumulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06eb449b069cde9c5aa5a8a6ac29df9
https://doi.org/10.1073/pnas.2221045120
https://doi.org/10.1073/pnas.2221045120
Autor:
Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Emma M. Lessieur, Yunpeng Du, Jie Tang, Jianying Kiser, Xiao Yang, Timothy S. Kern, Kaustabh Ghosh
Vascular inflammation is known to cause degeneration of retinal vessels in early diabetic retinopathy (DR). Past studies investigating these diabetes-induced vascular abnormalities have focused primarily on the role of molecular or biochemical cues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d9442d0db3619220f088a36a09ad539
https://doi.org/10.1101/2022.12.18.520943
https://doi.org/10.1101/2022.12.18.520943
Publikováno v:
Diabetologia. 65(10)
Induction of intercellular adhesion molecule-1 (ICAM-1) has been implicated in the development of macrovascular and microvascular diseases such as diabetic retinopathy. Lesions of diabetic retinopathy are unique to the retina but the reason for this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08dce603d105caf388f580aa35a48546
https://pubmed.ncbi.nlm.nih.gov/35852587
https://pubmed.ncbi.nlm.nih.gov/35852587
Autor:
Michelle A, Cruz, Dillon, Bohinc, Elizabeth A, Andraska, Jurgis, Alvikas, Shruti, Raghunathan, Nicole A, Masters, Nadine D, van Kleef, Kara L, Bane, Kathryn, Hart, Kathryn, Medrow, Michael, Sun, Haitao, Liu, Shannon, Haldeman, Ankush, Banerjee, Emma M, Lessieur, Kara, Hageman, Agharnan, Gandhi, Maria, de la Fuente, Marvin T, Nieman, Timothy S, Kern, Coen, Maas, Steven, de Maat, Keith B, Neeves, Matthew D, Neal, Anirban, Sen Gupta, Evi X, Stavrou
Publikováno v:
Nature nanotechnology. 17(9)
Targeted drug delivery to disease-associated activated neutrophils can provide novel therapeutic opportunities while avoiding systemic effects on immune functions. We created a nanomedicine platform that uniquely utilizes an α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b06793d4132be82bf7b3753707708ef
https://pubmed.ncbi.nlm.nih.gov/36180549
https://pubmed.ncbi.nlm.nih.gov/36180549
Autor:
Timothy S. Kern, Xiangyi Wen, Bruce A. Berkowitz, Yunpeng Du, Masaru Miyagi, Emma M. Lessieur, Wallace B. Thoreson, Aicha Saadane, Jianying Kiser
Publikováno v:
Am J Pathol
This study tested the hypothesis that diabetes promotes a greater than normal cytosolic calcium level in rod cells that activates a Ca(2+)-sensitive protease, calpain, resulting in oxidative stress and inflammation, two pathogenic factors of early di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e226b5d1e9ed3abd145ed8b53c9f327
https://pubmed.ncbi.nlm.nih.gov/34214506
https://pubmed.ncbi.nlm.nih.gov/34214506
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238727 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238727 (2020)
PurposeFemale mice have been found to be resistant to streptozotocin (STZ)-induced diabetes, and pre-clinical research related to diabetic complications commonly omits females. The purpose of this study was to develop a method to induce diabetes in f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841443047279354014ce812f3cee79db
https://pubmed.ncbi.nlm.nih.gov/32941450
https://pubmed.ncbi.nlm.nih.gov/32941450