The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma

Autor: Richard Hewitt, Hugo Farne, Andrew Ritchie, Emma Luke, Sebastian L. Johnston, Patrick Mallia

Publikováno v: Therapeutic Advances in Respiratory Disease, Vol 10 (2016)

Asthma and chronic obstructive pulmonary disease (COPD) are major causes of global morbidity and mortality worldwide. The clinical course of both asthma and COPD are punctuated by the occurrence of exacerbations, acute events characterized by increas

Externí odkaz: https://doaj.org/article/035a8091469c445688de708b6149011a

Spatial distribution of human arachnoid trabeculae

Autor: Emma Luke, Yousef Alsanea, Nikolaus Benko, Brittany Coats

Publikováno v: J Anat

Traumatic brain injury (TBI) is a common injury modality affecting a diverse patient population. Axonal injury occurs when the brain experiences excessive deformation as a result of head impact. Previous studies have shown that the arachnoid trabecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30aeb23f5677fae5c4cb9c94fdc1256
https://doi.org/10.1111/joa.13186

Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model

Autor: Tejas S. Khire, Yan Yan, Emma Luke, Dale Glavin, Diána Hudecz, James L. McGrath, Morten Nielsen, Kenneth A. Dawson, Henry H. Chung, Laurent Adumeau

Publikováno v: Hudecz, D, Khire, T, Chung, H L, Adumeau, L, Glavin, D, Luke, E, Nielsen, M S, Dawson, K A, McGrath, J L & Yan, Y 2020, ' Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model ', ACS Nano, vol. 14, no. 1, pp. 1111-1122 . https://doi.org/10.1021/acsnano.9b08870

Here we present a blood-brain barrier (BBB) model that enables high-resolution imaging of nanoparticle (NP) interactions with endothelial cells and the capture of rare NP translocation events. The enabling technology is an ultrathin silicon nitride (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b1aa4934ec3cd1b0a197bbba19cb89

039 Comparative review of clinical features, management and outcome of patients with ultrahyperferritinaemia (serum ferritin >10,000 ng/ml) under different specialties

Autor: Catherine Hockings, Christopher McNamara, Samuel Berhane, Animesh Singh, Emma Luke, Fang En Sin, Elizabeth Marrinan, Jin-Sup Shin, Kristina Clark, Jessica J Manson

Publikováno v: Rheumatology. 58

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aefc40956d9b2e76f29cbc33bb2bb21
https://doi.org/10.1093/rheumatology/kez106.038

A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood–brain barrier under flow

Autor: Fabien Gosselet, Adrien Mossu, Hideaki Nishihara, Britta Engelhardt, Tejas S. Khire, James L. McGrath, Maria Rosito, Federica Sallusto, Henry H. Chung, Lucie Dehouck, Isabelle Gruber, Emma Luke

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2018, 39 (3), pp.395-410. ⟨10.1177/0271678X18820584⟩
Mossu, Adrien; Rosito, Maria; Khire, Tejas; Li Chung, Hung; Nishihara, Hideaki; Gruber, Isabelle; Luke, Emma; Dehouck, Lucie; Sallusto, Federica; Gosselet, Fabien; McGrath, James L; Engelhardt, Britta (2019). A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow. Journal of cerebral blood flow and metabolism, 39(3), pp. 395-410. Sage 10.1177/0271678X18820584

International audience; Here we report on the development of a breakthrough microfluidic human in vitro cerebrovascular barrier (CVB) model featuring stem cell-derived brain-like endothelial cells (BLECs) and nanoporous silicon nitride (NPN) membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0168ce40f91711c21f5be97add5249d1
http://hdl.handle.net/11573/1608996