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Akademický článek

Exposure to the antiretroviral drug dolutegravir impairs structure and neurogenesis in a forebrain organoid model of human embryonic cortical development

Autor: Emma LaNoce, Daniel Y. Zhang, Alan Garcia-Epelboim, Yijing Su, Yusha Sun, Giana Alepa, Angelina R. Angelucci, Cagla Akay-Espinoza, Kelly L. Jordan-Sciutto, Hongjun Song, Guo-li Ming, Kimberly M. Christian

Publikováno v: Frontiers in Molecular Neuroscience, Vol 17 (2024)

IntroductionFor many therapeutic drugs, including antiretroviral drugs used to treat people living with HIV-1 (PLWH), we have little data on the potential effects on the developing human brain due to limited access to tissue and historical constraint

Externí odkaz: https://doaj.org/article/474d3437c0cf49128cbae36e4c3182d6

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Akademický článek

Using 2D and 3D pluripotent stem cell models to study neurotropic viruses

Autor: Emma LaNoce, Jeriel Dumeng-Rodriguez, Kimberly M. Christian

Publikováno v: Frontiers in Virology, Vol 2 (2022)

Understanding the impact of viral pathogens on the human central nervous system (CNS) has been challenging due to the lack of viable human CNS models for controlled experiments to determine the causal factors underlying pathogenesis. Human embryonic

Externí odkaz: https://doaj.org/article/c6f17b9b7f7a47f4b762dad4aeaf4029

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Lateralized Decrease of Parvalbumin+ Cells in the Somatosensory Cortex of ASD Models Is Correlated with Unilateral Tactile Hypersensitivity

Autor: Tara Deemyad, Hang Qi, Emma LaNoce, Gregory M LaRocca, Nathaniel N. Urban, Deepthi Aravind, Stephanie Puig, Andrew E. Papale

Publikováno v: Cereb Cortex

Inhibitory control of excitatory networks contributes to cortical functions. Increasing evidence indicates that parvalbumin (PV+)-expressing basket cells (BCs) are a major player in maintaining the balance between excitation (E) and inhibition (I). D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8865adac697aca25a9caf33d7aa34f5
https://doi.org/10.1093/cercor/bhab233

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Lateralized decrease of parvalbumin+ cells in the somatosensory cortex of ASD models is correlated with unilateral tactile hypersensitivity

Autor: Stephanie Puig, Emma LaNoce, Nathaniel N. Urban, Hang Qi, Deepthi Aravind, Andrew E. Papale, Tara Deemyad, Gregory M LaRocca

Inhibitory control of excitatory networks contributes to cortical functions. Increasing evidence indicates that parvalbumin expressing (PV+) basket cells (BC) are a major player in maintaining the balance between excitation (E) and inhibition (I) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6bbee6d1202dff0c8d19658428ffdb1
https://doi.org/10.1101/2020.09.08.288654

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