Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emma L. Shepherd"'
Autor:
Alex L. Wilkinson, Samuel Hulme, James I. Kennedy, Emily R. Mann, Paul Horn, Emma L. Shepherd, Kelvin Yin, Marco Y.W. Zaki, Gareth Hardisty, Wei-Yu Lu, Pia Rantakari, David H. Adams, Marko Salmi, Matthew Hoare, Daniel A. Patten, Shishir Shetty
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107966- (2023)
Summary: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell
Externí odkaz:
https://doaj.org/article/58c0bb4699c74d3e8cde69d28ccda647
Autor:
Abhishek Chauhan, Lozan Sheriff, Mohammed T. Hussain, Gwilym J. Webb, Daniel A. Patten, Emma L. Shepherd, Robert Shaw, Christopher J. Weston, Debashis Haldar, Samuel Bourke, Rajan Bhandari, Stephanie Watson, David H. Adams, Steve P. Watson, Patricia F. Lalor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during a
Externí odkaz:
https://doaj.org/article/a6f8dbdcb34b42c0a82ada447cf8eac9
Autor:
Emma L. Shepherd, Raquel Saborano, Ellie Northall, Kae Matsuda, Hitomi Ogino, Hiroaki Yashiro, Jason Pickens, Ryan E. Feaver, Banumathi K. Cole, Stephen A. Hoang, Mark J. Lawson, Matthew Olson, Robert A. Figler, John E. Reardon, Nobuhiro Nishigaki, Brian R. Wamhoff, Ulrich L. Günther, Gideon Hirschfield, Derek M. Erion, Patricia F. Lalor
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100217- (2021)
Background & Aims: Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylatio
Externí odkaz:
https://doaj.org/article/4340ddc01197436fbd613f61ff255144
Autor:
Emma L. Shepherd, Ellie Northall, Pantelitsa Papakyriacou, Karolina Safranska, Karen K. Sorensen, Patricia F. Lalor
Publikováno v:
Methods in Molecular Biology ISBN: 9781071632062
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155cfb3d34eca379d08a6d33078a1266
https://doi.org/10.1007/978-1-0716-3207-9_14
https://doi.org/10.1007/978-1-0716-3207-9_14
Autor:
Brandon A. Coke, Emma L. Shepherd, Nikolas J. Hodges, Kyriaki Chatzi, Timothy Schulz-utermoehl, Nicholas J. Coltman, Patricia F. Lalor
Publikováno v:
Toxicology Letters. 345:34-45
HepG2 cells continue to be a valuable tool in early drug discovery and pharmaceutical development. In the current study we develop a 3D in vitro liver model, using HepG2/C3A cells that is predictive of human genotoxic exposure. HepG2/C3A cells cultur
Publikováno v:
World Journal of Hepatology. 12:931-948
Background Non-alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance and dyslipidaemia and currently is estimated to affect up to a third of all individuals in developed countries. Current standard of care for patients
Publikováno v:
Seminars in Liver Disease. 39:111-123
Immune dysregulation and accumulation of leukocytes is a hallmark of adult chronic liver diseases. Progressive hepatic inflammation can lead to fibrosis and cirrhosis with a high risk of liver failure or hepatocellular cancer (HCC). Recent advances h
Autor:
Ellie Northall, Banumathi K. Cole, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson, Stephen A. Hoang, Kae Matsuda, Ulrich L. Günther, Mark J. Lawson, Ryan E. Feaver, Jason Pickens, Patricia F. Lalor, Raquel Saborano, Robert A. Figler, Hiroaki Yashiro, Derek M. Erion, Hitomi Ogino, Emma L. Shepherd, Gideon M. Hirschfield, Nobuhiro Nishigaki
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100217-(2021)
JHEP Reports
JHEP Reports
Background & Aims Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylation
Publikováno v:
World Journal of Hepatology
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance and dyslipidaemia and currently is estimated to affect up to a third of all individuals in developed countries. Current standard of care for patients
Autor:
Daniel A. Patten, Sivesh K. Kamarajah, Joanne M. Rose, Joseph Tickle, Emma L. Shepherd, David H. Adams, Chris J. Weston, Shishir Shetty
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Liver-resident cells are constantly exposed to gut-derived antigens via portal blood and, as a consequence, they express a unique repertoire of scavenger receptors. Whilst there is increasing evidence that the gut contributes to chronic inflammatory