Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Emma L. McInturff"'
Autor:
Andrew C. Flick, Carolyn A. Leverett, Hong X. Ding, Emma L. McInturff, Sarah J. Fink, Subham Mahapatra, Daniel W. Carney, Erick A. Lindsey, Jacob C. DeForest, Scott P. France, Simon Berritt, Simone V. Bigi-Botterill, Tony S. Gibson, Rebecca B. Watson, Yiyang Liu, Christopher J. O’Donnell
Publikováno v:
Journal of medicinal chemistry. 65(14)
New drugs introduced to the market are privileged structures that have affinities for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small molecules and antibody-drug conjugates (ADCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f55f5674a38fa5e3d2a73c73d3aa77
https://pubmed.ncbi.nlm.nih.gov/35833579
https://pubmed.ncbi.nlm.nih.gov/35833579
Autor:
Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan, Yi-Yin Ku, Michael D. Wendt, Robert Dugger, Bryan Li, Paul Richardson, Rémy Angelaud, Steve Staben, Timothy Heffron, Andreas Schuster, Frédéric St-Jean, Stefan G. Koenig, Thomas H. Pillow, Andreas Stumpf, Daniel Sutherlin, Christoph M. Dehnhardt, Neil F. Langille, Daniel B. Horne, David C. Blakemore, Thomas Brandt, Craig Knight, Sarah E. Skerratt, Christian Harcken, Joshuaine Grant, Hossein Razavi, Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Jonathan T. Reeves, James J. Crawford, Haiming Zhang, David W. Piotrowski, Emma L. McInturff, Andrew J. Peat, Shiping Xie
Publikováno v:
Organic Letters. 19:966-968
Upon exposure to a ruthenium(0) catalyst, N-benzyl 3-hydroxy-2-oxindoles react with diverse alkynes to form products of C-H vinylation with complete control of regioselectivity and olefin geometry. This method contributes to a growing body of catalyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6973cd9f0da0eb7302e160a33a8591da
https://doi.org/10.1021/acs.orglett.7b00174
https://doi.org/10.1021/acs.orglett.7b00174
Publikováno v:
Angewandte Chemie International Edition. 53:3232-3235
Direct ruthenium-catalyzed CC coupling of alkynes and vicinal diols to form β,γ-unsaturated ketones occurs with complete levels of regioselectivity and good to complete control over the alkene geometry. Exposure of the reaction products to substoic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2aef49fb0b582342493566b8721561
https://doi.org/10.1002/anie.201311130
https://doi.org/10.1002/anie.201311130
Publikováno v:
ChemInform. 45
The coupling of alkynes and vicinal diols proceeds with complete levels of regioselectivity and good to complete control over the alkene geometry to yield β,γ-unsaturated ketones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6423c12b7331ec624880506f15ff18
https://doi.org/10.1002/chin.201436033
https://doi.org/10.1002/chin.201436033
Publikováno v:
ChemInform. 45
Under the conditions of ruthenium(0)-catalyzed hydrohydroxyalkylation, vicinal diols 1a–1l and methyl acrylate 2a are converted to the corresponding lactones 3a–3l in good to excellent yield. The reactions of methyl acrylate 2a with hydrobenzoin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0938e6be16c4f4fb8aa1d951268fdb
https://doi.org/10.1002/chin.201422033
https://doi.org/10.1002/chin.201422033
Publikováno v:
Organic Letters. 12:2514-2516
Exposure of alcohols to allenamides in the presence of RuHCl(CO)(PPh(3))(3) and dippf [dippf = bis(diisopropylphosphino)ferrocene] results in hydrogen transfer to generate aldehyde-allylruthenium pairs, which engage in C-C coupling to form products o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804f0ea357df2a6a116cf112cec3ae7c
https://doi.org/10.1021/ol1007235
https://doi.org/10.1021/ol1007235
Publikováno v:
Journal of the American Chemical Society. 135(45)
Under the conditions of ruthenium(0) catalyzed hydrohydroxyalkylation, vicinal diols 1a–1l and methyl acrylate 2a are converted to the corresponding lactones 3a–3l in good to excellent yield. The reaction of methyl acrylate 2a with hydrobenzoin 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f609ded9c10faec0ec3aea1880f3eba
https://pubmed.ncbi.nlm.nih.gov/24187991
https://pubmed.ncbi.nlm.nih.gov/24187991
Publikováno v:
ChemInform. 44
The ruthenium catalyst generated in situ from H2Ru(CO)(PPh3)3, (S)-SEGPHOS, and a TADDOL-derived phosphoric acid (TPA) promotes butadiene hydrohydroxyalkylation to form enantiomerically enriched products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49d6d20032bb77c7c40c9567e75dd50d
https://doi.org/10.1002/chin.201322047
https://doi.org/10.1002/chin.201322047
The ruthenium catalyst generated in situ from H(2)Ru(CO)(PPh(3))(3), (S)-SEGPHOS, and a TADDOL-derived phosphoric acid promotes butadiene hydrohydroxyalkylation to form enantiomerically enriched products. Notably, the observed diastereo- and enantios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fe84f201ffbd3f76bcb0a4c5ef9a10
https://europepmc.org/articles/PMC3531795/
https://europepmc.org/articles/PMC3531795/