Výsledky vyhledávání - "Emma L. Kaplan"

Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase

Publikováno v: Journal of Medicinal Chemistry. 43:236-249

N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+

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Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)

Autor: Emma L. Kaplan, Jiaping Gao, Leonard J. Brand, Robert E. Damon, Judit Koletar, Christine C. Vinluan, Suraj S. Shetty, Thomas Daniel Aicher, William R. Mann

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 9:2223-2228

Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7845fb3e46576be1780877fa834d49f
https://doi.org/10.1016/s0960-894x(99)00380-7

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(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase

Publikováno v: Journal of Medicinal Chemistry. 42:2741-2746

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d109ec966714cd20d37ebc973dd61
https://doi.org/10.1021/jm9902584

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The effects of wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA synthesis

Autor: Barbara E. Womelsdorf, Christian M. Honer, Emma L. Kaplan, Philip A. Bell, Joseph L. Evans

Publikováno v: Cellular Signalling. 7:365-376

PI 3-kinase, an enzyme that selectively phosphorylates the 3-position of the inositol ring, is acutely activated by insulin and other growth factors. The physiological significance of PI 3-kinase activation and, more specifically, its role in insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8da99a527f81fe2dab7440ec3251a1
https://doi.org/10.1016/0898-6568(95)00007-c

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ChemInform Abstract: Triterpene and Diterpene Inhibitors of Pyruvate Dehydrogenase Kinase (PDK)

Autor: Emma L. Kaplan, William R. Mann, Suraj S. Shetty, Christine C. Vinluan, Judit Koletar, Robert E. Damon, Jiaping Gao, Leonard J. Brand, Thomas Daniel Aicher

Publikováno v: ChemInform. 30

Several oximes of triterpenes with a 17-β hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bffb978b3fe8103e27196390eda837ac
https://doi.org/10.1002/chin.199945217

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Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase

Publikováno v: Journal of medicinal chemistry. 43(11)

The optimization of a series of anilide derivatives of (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9230c1ef002859de18c4f7fe1f8ef950
https://pubmed.ncbi.nlm.nih.gov/10841803

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