Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emma L. Handy"'
Autor:
David W Morgens, Charlene Chan, Andrew J Kane, Nicholas R Weir, Amy Li, Michael M Dubreuil, C Kimberly Tsui, Gaelen T Hess, Adam Lavertu, Kyuho Han, Nicole Polyakov, Jing Zhou, Emma L Handy, Philip Alabi, Amanda Dombroski, David Yao, Russ B Altman, Jason K Sello, Vladimir Denic, Michael C Bassik
Publikováno v:
eLife, Vol 8 (2019)
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi
Externí odkaz:
https://doaj.org/article/f8b0b64eb9da49ff8b1b2ae4b6712fa1
Autor:
Evan Craig, Charles-Eugene Huyghues-Despointes, Chun Yu, Emma L Handy, Jason K Sello, Peter E Kima
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005556 (2017)
In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LP
Externí odkaz:
https://doaj.org/article/bf7770f55c804ed49eee5c3ec3267f42
Autor:
Jason K. Sello, Shashank Gupta, Robert T. Sauer, Emma L. Handy, Corey L. Compton, William R. Bishai, Karl R. Schmitz
Publikováno v:
ACS Chemical Biology. 18:724-733
Proteolytic complexes in Mycobacterium tuberculosis (Mtb), the deadliest bacterial pathogen, are major foci in tuberculosis drug development programs. The Clp proteases, which are essential for Mtb viability, are high priority targets. These protease
Autor:
Adam Lavertu, Nicholas R. Weir, Amanda Dombroski, Amy Li, Nicole J. Polyakov, David Yao, Vladimir Denic, Jing Zhou, Charlene Chan, Gaelen T. Hess, David W. Morgens, Kyuho Han, Andrew J Kane, Jason K. Sello, C. Kimberly Tsui, Michael M. Dubreuil, Russ B. Altman, Philip Alabi, Emma L. Handy, Michael C. Bassik
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi
Autor:
Charlene Chan, Andrew J Kane, David W. Morgens, C. Kimberly Tsui, Amanda Dombroski, Amy Li, Nicholas R. Weir, Gaelen T. Hess, Russ B. Altman, Vladimir Denic, Jing Zhou, Emma L. Handy, Adam Lavertu, Jason K. Sello, Kyuho Han, Michael C. Bassik, Philip Alabi, Michael M. Dubreuil, David Yao, Nicole J. Polyakov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdab76f48078f5cb90043821815d13a1
https://doi.org/10.7554/elife.48434.022
https://doi.org/10.7554/elife.48434.022
Autor:
Peter E. Kima, Charles-Eugene Huyghues-Despointes, Jason K. Sello, Chun Yu, Emma L. Handy, Evan Craig
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005556 (2017)
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005556 (2017)
In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LP
Autor:
Emma L. Handy, Timothy P. Curran
Publikováno v:
Journal of Organometallic Chemistry. 694:902-907
Prior work has shown that covalently linking the side chains of amino acids in the i and i+3 and i and i+4 positions in a peptide will enforce a helical conformation. In this work the ability of an organometallic entity to enforce a helical conformat
Autor:
Emma L. Handy, Jason K. Sello
Publikováno v:
Topics in Heterocyclic Chemistry ISBN: 9783319491172
Piperazic acid and its congeners are constituents of many structurally complex natural products. Their conformational rigidity and other advantageous physicochemical properties have motivated the incorporation of these non-proteinogenic amino acids i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adb5a095574997172eeb59e51fdfdc6c
https://doi.org/10.1007/7081_2015_185
https://doi.org/10.1007/7081_2015_185
Publikováno v:
ChemInform. 46
The synthesis of piperazic acid derivatives via a novel multicomponent reaction of tetrahydropyridazines, isocyanides, and carboxylic acids is presented.
Publikováno v:
Organic letters. 16(13)
Peptides containing N2-acyl piperazic or 1,6-dehydropiperazic acids can be formed efficiently via a novel multicomponent reaction of 1,4,5,6-tetrahydropyridazines, isocyanides, and carboxylic acids. Remarkably, the reaction's induced intramolecularit