Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Emma L. Cambridge"'
Autor:
Lynda Mottram, Anneliese O. Speak, Reza M. Selek, Emma L. Cambridge, Zoe McIntyre, Leanne Kane, Subhankar Mukhopadhyay, Carolyn Grove, Amy Colin, Cordelia Brandt, Maria A. Duque-Correa, Jessica Forbester, Tu Anh Pham Nguyen, Christine Hale, George S. Vasilliou, Mark J. Arends, Brendan W. Wren, Gordon Dougan, Simon Clare
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT Mice harboring a mutation in the gene encoding gastric intrinsic factor (Gif), a protein essential for the absorption of vitamin B12/cobalamin (Cbl), have potential as a model to explore the role of vitamins in infection. The levels of Cbl i
Externí odkaz:
https://doaj.org/article/82528246208e4de2981928bb9b56c77c
Autor:
Maria O. Levitin, Lettie E Rawlins, Gabriela Sanchez-Andrade, Osama A. Arshad, Stephan C. Collins, Stephen J. Sawiak, Phillip H. Iffland, Malin H.L. Andersson, Caleb Bupp, Emma L. Cambridge, Eve L. Coomber, Ian Ellis, Johanna C. Herkert, Holly Ironfield, Logan Jory, Perrine F. Kretz, Sarina G. Kant, Alexandra Neaverson, Esther Nibbeling, Christine Rowley, Emily Relton, Mark Sanderson, Ethan M. Scott, Helen Stewart, Andrew Y. Shuen, John Schreiber, Liz Tuck, James Tonks, Thorkild Terkelsen, Conny van Ravenswaaij-Arts, Pradeep Vasudevan, Olivia Wenger, Michael Wright, Andrew Day, Adam Hunter, Minal Patel, Christopher J. Lelliott, Peter B. Crino, Binnaz Yalcin, Andrew Crosby, Emma L. Baple, Darren W. Logan, Matthew E. Hurles, Sebastian S. Gerety
KPTN-related disorder (KRD) is an autosomal recessive disorder associated with germline variants in KPTN (kaptin), a component of the mTOR regulatory complex KICSTOR. To gain further insights into the pathogenesis of KRD, we analysed mouse knockout a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4cbb0278fd0279fd1689af80476ba3a
https://doi.org/10.1101/2022.07.15.500213
https://doi.org/10.1101/2022.07.15.500213
Autor:
Kim Wong, Nicola Griggs, Elizabeth Tuck, Sarah Spiegel, Emma L. Cambridge, Antonella Galli, Sanger Mouse Genetics, Hannah Wardle-Jones, Louise van der Weyden, Anneliese O. Speak, Natasha A. Karp, Andrew D. Campbell, Martin Del Castillo Velasco-Herrera, Owen J. Sansom, Thierry Voet, Thomas Tüting, Edward Ryder, Diane Gleeson, David J. Adams, Mark J. Arends, Iain C. Macaulay, Simon Clare, Tobias Bald
Publikováno v:
van der Weyden, L, Arends, M J, Campbell, A D, Bald, T, Wardle-Jones, H, Griggs, N, Del Castillo Velasco-Herrera, M, Tüting, T, Sansom, O J, Karp, N A, Clare, S, Gleeson, D, Ryder, E, Galli, A, Tuck, E, Cambridge, E L, Voet, T, Macaulay, I C, Wong, K, Spiegel, S & Speak, A O & Adams, D J 2017, ' Genome-wide in vivo screen identifies novel host regulators of metastatic colonisation ', Nature, vol. 541, no. 7636, pp. 233-236 . https://doi.org/10.1038/nature20792
Metastasis is the leading cause of death for cancer patients. This multi-stage process requires tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it involves contributions from both the tumour cell and tumour
Autor:
Maria A. Duque Correa, Simon P. Forman, Anneliese O. Speak, Dmitry S. Ushakov, Natasha A. Karp, Susana Caetano, Heather M. Wilson, George X. Song-Zhao, Matthew Edmans, Jacqueline K. White, Adam Laing, Namita Saran, Kevin J. Maloy, Justin Meskas, Sibyl Drissler, Emma L. Cambridge, Anna Chan, William R. Jacobs, Jua Iwasaki, Eleanor Cawthorne, Ramiro Ramirez-Solis, Alice Yue, Markus Pasztorek, Tanya L. Crockford, Richard K. Grencis, Amrutha Meeniga, Adrian Hayday, Cordelia Brandt, Albina Rahim, Terrence F. Meehan, Markus Lux, Leanne Kane, Belén Morón, George Notley, Johannes Abeler, Natasha Strevens, Keng I. Hng, Mark Griffiths, Carmen Ballesteros Reviriego, Katherine Harcourt, Fiona Powrie, Richard J. Cornall, David Melvin, Jeremy Mason, Jonathan Warren, David J. Adams, Simon Clare, Katherine R. Bull, Ryan R. Brinkman, Anna Lorenc, Gillian M. Griffiths, K. O. Babalola, Gordon Dougan, Brian Weinrick, Clare M. Lloyd, Lucie Abeler-Dörner, Philippa R. Barton, Agnieszka Przemska-Kosicka
Publikováno v:
Forman, S, Grencis, R & et al. 2019, ' High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation ', Nature Immunology, vol. 21, pp. 86-100 . https://doi.org/10.1038/s41590-019-0549-0
Nat Immunol
Nat Immunol
By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput phenotyping of 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2af8846d8b60da029e9a0d672bfa60
Autor:
Jacqueline K. White, Emma L. Cambridge, Anneliese O. Speak, Susana Caetano, Diane Gleeson, Louise van der Weyden, Katherine Harcourt, Edward Ryder, David Goulding, Leanne Kane, Brendan Doe, David J. Adams, Agnieszka Swiatkowska, Mark J. Arends, Gordon Dougan, Bushra Abu-Helil, Simon Clare, Carmen Ballesteros Reviriego
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212481 (2019)
PLoS ONE
Ballesteros Reviriego, C, Clare, S, Arends, M, Cambridge, E L, Swiatkowska, A, Caetano, S, Abu-Helil, B, Kane, L, Harcourt, K, Goulding, D, Gleeson, D, Ryder, E, Doe, B, White, J K, van der Weyden, L, Dougan, G, Adams, D J & Speak, A O 2019, ' FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele ', PLoS ONE, vol. 14, no. 3 . https://doi.org/10.1371/journal.pone.0212481
PLoS ONE
Ballesteros Reviriego, C, Clare, S, Arends, M, Cambridge, E L, Swiatkowska, A, Caetano, S, Abu-Helil, B, Kane, L, Harcourt, K, Goulding, D, Gleeson, D, Ryder, E, Doe, B, White, J K, van der Weyden, L, Dougan, G, Adams, D J & Speak, A O 2019, ' FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele ', PLoS ONE, vol. 14, no. 3 . https://doi.org/10.1371/journal.pone.0212481
FBXO7 encodes an F box containing protein that interacts with multiple partners to facilitate numerous cellular processes and has a canonical role as part of an SCF E3 ubiquitin ligase complex. Mutation of FBXO7 is responsible for an early onset Park
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc680df5e362c0b09b46f701cb4b40a0
https://www.repository.cam.ac.uk/handle/1810/290682
https://www.repository.cam.ac.uk/handle/1810/290682
Autor:
María A Duque-Correa, Natasha A Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P Jenkins, Adam J Reid, Emma L Cambridge, Carmen Ballesteros Reviriego, Sanger Mouse Genetics Project, 3i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K Grencis, Matthew Berriman
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007265 (2019)
PLoS Pathogens
Sanger Mouse Genetics Project 2019, ' Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection ', PLoS Pathogens, vol. 15, no. 1, pp. e1007265 . https://doi.org/10.1371/journal.ppat.1007265
PLoS Pathogens
Sanger Mouse Genetics Project 2019, ' Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection ', PLoS Pathogens, vol. 15, no. 1, pp. e1007265 . https://doi.org/10.1371/journal.ppat.1007265
The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59300cac3e5d1f6714b6f47067b7fa3a
https://doi.org/10.1101/388173
https://doi.org/10.1101/388173
Autor:
Maria A, Stacey, Simon, Clare, Mathew, Clement, Morgan, Marsden, Juneid, Abdul-Karim, Leanne, Kane, Katherine, Harcourt, Cordelia, Brandt, Ceri A, Fielding, Sarah E, Smith, Rachael S, Wash, Silvia Gimeno, Brias, Gabrielle, Stack, George, Notley, Emma L, Cambridge, Christopher, Isherwood, Anneliese O, Speak, Zoë, Johnson, Walter, Ferlin, Simon A, Jones, Paul, Kellam, Ian R, Humphreys
Publikováno v:
The Journal of Clinical Investigation
The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans. Here, we used the murine CMV (MCMV) mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b5d0f260eb058d4a4aee340511cab30
http://hdl.handle.net/10044/1/69587
http://hdl.handle.net/10044/1/69587
Autor:
Emma L. Cambridge, Jeanne Estabel, Jacqueline K. White, Christopher J. Lelliott, Damian M. Carragher, Christine Podrini, Cheryl L. Scudamore, Sanger Mouse Genetics, Anna-Karin Gerdin, Natasha A. Karp, Ramiro Ramirez-Solis
Publikováno v:
Mammalian Genome
C57BL/6N (B6N) is becoming the standard background for genetic manipulation of the mouse genome. The B6N, whose genome is very closely related to the reference C57BL/6J genome, is versatile in a wide range of phenotyping and experimental settings and
Autor:
Tu Anh Pham Nguyen, Amy Colin, George S. Vasilliou, Reza M. Selek, Anneliese O. Speak, Emma L. Cambridge, Simon Clare, Brendan W. Wren, Christine Hale, Gordon Dougan, Cordelia Brandt, María A. Duque-Correa, Leanne Kane, Lynda Mottram, Subhankar Mukhopadhyay, Zoe McIntyre, Mark J. Arends, Jessica L. Forbester, Carolyn Grove
Publikováno v:
mBio, Vol 7, Iss 3, p e00830-16 (2016)
mBio, Vol 7, Iss 3 (2016)
Mottram, L F, Speak, A O, Selek, R M, Cambridge, E L, McIntyre, Z, Kane, L, Mukhopadhyay, S, Grove, C, Colin, A, Duque-Corre, M A, Forbester, J, Nguyen, T A P, Hale, C, Vasilliou, G S, Arends, M, Wren, B W, Dougan, G & Clare, S 2016, ' Infection susceptibility in gastric intrinsic factor (vitamin B12) defective mice is subject to maternal influences ', mBio, vol. 7, no. 3, e00830-16 . https://doi.org/10.1128/mBio.00830-16
mBio
mBio, Vol 7, Iss 3 (2016)
Mottram, L F, Speak, A O, Selek, R M, Cambridge, E L, McIntyre, Z, Kane, L, Mukhopadhyay, S, Grove, C, Colin, A, Duque-Corre, M A, Forbester, J, Nguyen, T A P, Hale, C, Vasilliou, G S, Arends, M, Wren, B W, Dougan, G & Clare, S 2016, ' Infection susceptibility in gastric intrinsic factor (vitamin B12) defective mice is subject to maternal influences ', mBio, vol. 7, no. 3, e00830-16 . https://doi.org/10.1128/mBio.00830-16
mBio
Mice harboring a mutation in the gene encoding gastric intrinsic factor (Gif), a protein essential for the absorption of vitamin B12/cobalamin (Cbl), have potential as a model to explore the role of vitamins in infection. The levels of Cbl in the blo
Autor:
Zoe McIntyre, David J. Adams, David Goulding, Susana Caetano, Mark J. Arends, Christopher Isherwood, Agnieszka Swiatkowska, Anneliese O. Speak, Carmen Ballesteros Reviriego, Katherine Harcourt, Leanne Kane, Emma L. Cambridge, Jacqueline K. White, Simon Clare
Publikováno v:
Experimental Hematology
Failure to maintain a normal in vivo erythrocyte half-life results in the development of hemolytic anemia. Half-life is affected by numerous factors, including energy balance, electrolyte gradients, reactive oxygen species, and membrane plasticity. T