Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emma L. Bolton"'
Autor:
Yanwen eWang, Hoyee eTsui, Emma L Bolton, xin ewang, Christopher L Huang, R. John Solaro, Yunbo eKe, Ming eLei
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
A series of recent studies report novel roles for Pak1, a key member of the highly conserved family of serine-threonine protein kinases regulated by Ras-related small G-proteins, Cdc42/Rac1, in cardiac physiology and cardioprotection. Previous studie
Externí odkaz:
https://doaj.org/article/8273ffd1295c49dcaaeca6f56b3141b6
Autor:
Wilian A. Cortopassi, Matylda K. Maciejewska, Emma L. Bolton, Antony Galione, Derek A. Terrar, Clive Garnham, Matthew P. Jacobson, Rebecca Sitsapesan, Yanwen Wang, Wee Khang Lin, Margarida Ruas, Fiona O'Brien, John Parrington, Ming Lei
Publikováno v:
The Journal of biological chemistry, vol 292, iss 32
Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are Ca2+-mobilizing messengers important for modulating cardiac excitation–contraction coupling and pathophysiology. CD38, which belongs to the ADP-ribosyl cyclase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23032b4c6af97ff691dd8926e51035c7
https://ora.ox.ac.uk/objects/uuid:d003918c-a20a-4401-95e7-67af7500e26e
https://ora.ox.ac.uk/objects/uuid:d003918c-a20a-4401-95e7-67af7500e26e
Autor:
Wee K, Lin, Emma L, Bolton, Wilian A, Cortopassi, Yanwen, Wang, Fiona, O'Brien, Matylda, Maciejewska, Matthew P, Jacobson, Clive, Garnham, Margarida, Ruas, John, Parrington, Ming, Lei, Rebecca, Sitsapesan, Antony, Galione, Derek A, Terrar
Publikováno v:
The Journal of Biological Chemistry
Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are Ca2+-mobilizing messengers important for modulating cardiac excitation–contraction coupling and pathophysiology. CD38, which belongs to the ADP-ribosyl cyclase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fa0637a2d50f1070f0d266dbbc65c88
https://pubmed.ncbi.nlm.nih.gov/28539361
https://pubmed.ncbi.nlm.nih.gov/28539361
Autor:
Yanwen Wang, Wee Khang Lin, William Crawford, Haibo Ni, Emma L. Bolton, Huma Khan, Julia Shanks, Gil Bub, Xin Wang, David J. Paterson, Henggui Zhang, Antony Galione, Steven N. Ebert, Derek A. Terrar, Ming Lei
Publikováno v:
Scientific Reports
Wang, Y, Lin, W K, Crawford, W, Ni, H, Bolton, E L, Khan, H, Shanks, J, Bub, G, Wang, X, Paterson, D J, Zhang, H, Galione, A, Ebert, S N, Terrar, D A & Lei, M 2017, ' Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt + Cells in Murine Heart ', Scientific Reports, vol. 7, 40687 . https://doi.org/10.1038/srep40687
Wang, Y, Lin, W K, Crawford, W, Ni, H, Bolton, E L, Khan, H, Shanks, J, Bub, G, Wang, X, Paterson, D J, Zhang, H, Galione, A, Ebert, S N, Terrar, D A & Lei, M 2017, ' Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt + Cells in Murine Heart ', Scientific Reports, vol. 7, 40687 . https://doi.org/10.1038/srep40687
In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::76c1c5548be5c539610d86288d2e1012
http://europepmc.org/articles/PMC5234027
http://europepmc.org/articles/PMC5234027
Autor:
Derek A. Terrar, Margarida Ruas da Silva, Duncan Bloor-Young, Chichonyi Aubrey Kalungia, Rebecca A. Bayliss, John Parrington, Emma L. Bolton, Grant C. Churchill, Antony Galione
Publikováno v:
Biophysical Journal. 104(2)
NAADP is a potent endogenous Ca2+-mobilising agent with actions in many cell types, including cardiac myocytes1,2. Our previous work suggests that NAADP causes Ca2+ release from an acidic endolysosomal store, leading to additional Ca2+ uptake by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a1f1435fae90c6d88267f723e18c65
Autor:
Wilian A. Cortopassi, Wee Khang Lin, Matylda K. Maciejewska, Ming Lei, Margarida Ruas, Derek A. Terrar, Fiona O'Brien, Emma L. Bolton, Antony Galione, Rebecca Sitsapesan, Yanwen Wang
Publikováno v:
Biophysical Journal. 110:262a
Previously, we have reported that nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are calcium mobilising messengers that have significant roles in excitation-contraction coupling and disease development of the hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edae22d221b19efb44749e7352ec9015
https://doi.org/10.1016/j.bpj.2015.11.1434
https://doi.org/10.1016/j.bpj.2015.11.1434
Publikováno v:
Heart. 100:A21.3-A22
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent endogenous Ca2+ mobilizing second messenger that is known to release Ca2+ from the acidic endolysosomal vesicles. Our previous work showed that intracellular application of NAADP led t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecd56d19c3adc2c70a33a626cd4987d7
https://doi.org/10.1136/heartjnl-2014-306916.65
https://doi.org/10.1136/heartjnl-2014-306916.65
Autor:
Rebecca A. Capel, Emma L. Bolton, Antony Galione, Yanwen Wang, Derek A. Terrar, Wee Khang Lin
Publikováno v:
Cardiovascular Research. 103:S21.5-S22
Background: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent endogenous Ca2+ mobilizing second messenger that is known to release Ca2+ from the acidic endolysosomal vesicles. Our previous work showed that intracellular application of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798e422ae7966416110107eb73801282
https://doi.org/10.1093/cvr/cvu082.64
https://doi.org/10.1093/cvr/cvu082.64
Autor:
Derek A. Terrar, Emma L. Bolton
Publikováno v:
Biophysical Journal. 100:575a
Anandamide is an endogenous ligand of G-protein coupled cannabinoid CB1 and CB2 receptors, which has been shown to have complex effects on the cardiovascular system culminating in a hypotensive response and a reduction in cardiac contractility. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c57c2f5b86c3a01321bf81ee7191caa
https://doi.org/10.1016/j.bpj.2010.12.3326
https://doi.org/10.1016/j.bpj.2010.12.3326
Autor:
Emma L. Bolton, Antony Galione, Rebecca A. Bayliss, Duncan Bloor-Young, Grant C. Churchill, Derek A. Terrar, Wee Khang Lin
Publikováno v:
Biophysical Journal. (2):242a
NAADP is a highly potent endogenous Ca2+-mobilising second-messenger forming part of the beta-adrenergic response in cardiac myocytes12. Our previous work suggests NAADP causes Ca2+-release from acidic endolysosomal stores, leading to additional upta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f41bb700f726e1743e023c76e00c131