Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emma L. Baker"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
Transamidation reactions are kinetically and thermodynamically challenging because of the stability of the amide starting materials. Here, the authors show a two-step process—activation of a secondary amide, followed by nickel-catalysed C–N bond
Externí odkaz:
https://doaj.org/article/c246e43ab97345fb9962efe853715b19
Autor:
Tristin E. Rose, Brendan M. O'Boyle, Justin A. Hilf, Emma L. Baker-Tripp, Zhengao Feng, Kevin Yang, Michael D. Bartberger, Oliver C. Losón, Neil A. O'Brien, Martina S. McDermott, Naeimeh Kamranpour, Weiping Jia, Tong Luo, Raul Ayala, John Glasby, Brian M. Stoltz, Dennis J. Slamon
Publikováno v:
Cancer Research. 83:6258-6258
Small molecule inhibitors of KRASG12C have garnered substantial interest as a targeted therapy for lung, colon and pancreatic cancers bearing this mutation. Data from multiple clinical programs have shown strong efficacy in lung tumors but diminished
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15ba4ee9065bbb96517a541de8c29e0
https://doi.org/10.1158/1538-7445.am2023-6258
https://doi.org/10.1158/1538-7445.am2023-6258
Publikováno v:
Angew Chem Int Ed Engl
We report a means to achieve the addition of two disparate nucleophiles to the amide carbonyl carbon in a single operational step. Our method takes advantage of non-precious metal catalysis and allows for the facile conversion of amides to chiral alc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be3022841fde4339b2766f7db41af0c
https://doi.org/10.1002/anie.202012048
https://doi.org/10.1002/anie.202012048
Autor:
Neil K. Garg, Yun-Fang Yang, Peng Liu, Noah F. Fine Nathel, Liana Hie, Xin Hong, Tejas K. Shah, Emma L. Baker, Kendall N. Houk
Publikováno v:
Nature
Amides are common functional groups that have been well studied for more than a century.1 They serve as the key building blocks of proteins and are present in an broad range of other natural and synthetic compounds. Amides are known to be poor electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35acc1d3c892ad4d12adc59e08fcf9ea
https://doi.org/10.1038/nature14615
https://doi.org/10.1038/nature14615
Publikováno v:
Chemical Science
Chemical science, vol 8, iss 9
Chemical science, vol 8, iss 9
We report a two-step approach to achieve the transamidation of secondary aliphatic amides using non-precious metal catalysis.
Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although
Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae759efe3cf09479938ef81d808e2bb
https://pubmed.ncbi.nlm.nih.gov/29163929
https://pubmed.ncbi.nlm.nih.gov/29163929
Publikováno v:
Journal of the American Chemical Society, vol 136, iss 42
Journal of the American Chemical Society
Journal of the American Chemical Society
The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening reaction to introduce the challenging alkyl chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9c67371057ff6ab5aff573e28f06bb
https://doi.org/10.1021/ja5087672
https://doi.org/10.1021/ja5087672
Autor:
Chris H. Senanayake, Neil K. Garg, Sarah M. Anthony, Jean-Nicolas Desrosiers, Emma L. Baker, Liana Hie
Publikováno v:
Angewandte Chemie (International ed. in English), vol 55, iss 48
Recent studies have demonstrated that amides can be used in nickel-catalyzed reactions that lead to cleavage of the amide C-N bond, with formation of a C-C or C-heteroatom bond. However, the general scope of these methodologies has been restricted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7e0c7aec2e8fde54798f7db8d7d630
https://escholarship.org/uc/item/0488k05h
https://escholarship.org/uc/item/0488k05h
Publikováno v:
ChemInform. 47
The first nickel-catalyzed Suzuki—Miyaura coupling of amides is reported, which proceeds by an uncommon cleavage of the amide C—N bond after N-tert-butoxycarbonyl activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fbe226026ca824a782187976f795931
https://doi.org/10.1002/chin.201622080
https://doi.org/10.1002/chin.201622080
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
Nature communications, vol 7, iss 1
A long-standing challenge in synthetic chemistry is the development of the transamidation reaction. This process, which involves the conversion of one amide to another, is typically plagued by unfavourable kinetic and thermodynamic factors. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8583e4e704d990459d5ac2ec471905c
http://europepmc.org/articles/PMC4876455
http://europepmc.org/articles/PMC4876455
Autor:
Neil K. Garg, Peng Liu, Tejas K. Shah, Emma L. Baker, Xin Hong, K. N. Houk, Noah F. Fine Nathel, Liana Hie, Yun-Fang Yang
Publikováno v:
ChemInform. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2228212fd804a21debf3a77fe739a41a
https://doi.org/10.1002/chin.201551059
https://doi.org/10.1002/chin.201551059