Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Emma L. Baar"'
Autor:
Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy, Dudley W. Lamming
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rapamycin extends lifespan in model organisms by targeting mTORC1, but exerts off-target side effects via inhibition of mTORC2. Here, the authors report the identification of a selective mTORC1 inhibitor, and show that it inhibits mTORC1 activity bot
Externí odkaz:
https://doaj.org/article/62fe1b728b0148059e306c8857df6c69
Autor:
Sebastian I Arriola Apelo, Amy Lin, Jacqueline A Brinkman, Emma Meyer, Mark Morrison, Jay L Tomasiewicz, Cassidy P Pumper, Emma L Baar, Nicole E Richardson, Mohammed Alotaibi, Dudley W Lamming
Publikováno v:
eLife, Vol 9 (2020)
Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifically reduces the lifespan of male
Externí odkaz:
https://doaj.org/article/c95333fc539a4d298a632aafbb9b83b4
Autor:
Deyang Yu, Jay L. Tomasiewicz, Shany E. Yang, Blake R. Miller, Matthew H. Wakai, Dawn S. Sherman, Nicole E. Cummings, Emma L. Baar, Jacqueline A. Brinkman, Faizan A. Syed, Dudley W. Lamming
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 236-248.e3 (2019)
Summary: Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which may mediate the beneficial effects of a CR diet. This model has be
Externí odkaz:
https://doaj.org/article/018f0f4ebaf5459995174a4d5fb9a25d
Autor:
Luigi Fontana, Nicole E. Cummings, Sebastian I. Arriola Apelo, Joshua C. Neuman, Ildiko Kasza, Brian A. Schmidt, Edda Cava, Francesco Spelta, Valeria Tosti, Faizan A. Syed, Emma L. Baar, Nicola Veronese, Sara E. Cottrell, Rachel J. Fenske, Beatrice Bertozzi, Harpreet K. Brar, Terri Pietka, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole, Matthew J. Merrins, Caroline M. Alexander, Michelle E. Kimple, Dudley W. Lamming
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 520-530 (2016)
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unc
Externí odkaz:
https://doaj.org/article/1ed29261866140baa6d36b0b1e57ae8a
Autor:
Nicole E. Richardson, Jay L. Tomasiewicz, Cassidy P. Pumper, Emma L. Baar, Mark Morrison, Sebastian I. Arriola Apelo, Emma Meyer, Dudley W. Lamming, Amy Lin, Mohammed I. Alotaibi, Jacqueline A. Brinkman
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifically reduces the lifespan of male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38f88e1a0f1d8d86a766a004768f2be
https://pubmed.ncbi.nlm.nih.gov/32720643
https://pubmed.ncbi.nlm.nih.gov/32720643
Autor:
Nicole E. Cummings, Emma L. Baar, Dawn S. Sherman, Faizan A. Syed, Dudley W. Lamming, Deyang Yu, Shany E. Yang, Jay L. Tomasiewicz, Blake R. Miller, Matthew H. Wakai, Jacqueline A. Brinkman
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 236-248.e3 (2019)
Summary: Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which may mediate the beneficial effects of a CR diet. This model has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1489ce626a298e0357822b016a8e21a
https://pubmed.ncbi.nlm.nih.gov/31577953
https://pubmed.ncbi.nlm.nih.gov/31577953
Autor:
Rashpal S. Dhillon, Luis A. Fernandez, Sophia M. Sdao, Emma L. Baar, Jeremy D. Rogers, Dudley W. Lamming, Brian A. Schmidt, Kevin W. Eliceiri, Nathan A. Truchan, Chetan Poudel, Matthew J. Merrins, Trillian Gregg, John M. Denu, Michelle E. Kimple
Publikováno v:
Diabetes
Aging is accompanied by impaired glucose homeostasis and an increased risk of type 2 diabetes, culminating in the failure of insulin secretion from pancreatic β-cells. To investigate the effects of age on β-cell metabolism, we established a novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3da9d0bb875e9105642b0016c380fb
https://doi.org/10.2337/db16-0432
https://doi.org/10.2337/db16-0432
Publikováno v:
Aging Cell
Summary Inhibition of the mTOR (mechanistic Target Of Rapamycin) signaling pathway robustly extends the lifespan of model organisms including mice. The precise molecular mechanisms and physiological effects that underlie the beneficial effects of rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e0dabec82c514faf41787ea77f1829
https://doi.org/10.1111/acel.12425
https://doi.org/10.1111/acel.12425
Autor:
Michelle E. Kimple, Sebastian I. Arriola Apelo, Cassidy P. Pumper, Faizan A. Syed, Nicole E. Cummings, Harpreet K. Brar, Emma L. Baar, Dudley W. Lamming, Joshua C. Neuman
Publikováno v:
Aging Cell
Summary Inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway by the FDA‐approved drug rapamycin has been shown to promote lifespan and delay age‐related diseases in model organisms including mice. Unfortunately, rapamycin ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d7d2a323fbfc698e2f43ae3a62499b
https://doi.org/10.1111/acel.12405
https://doi.org/10.1111/acel.12405
Autor:
Emma L. Baar, Amanda W. Hutchins, Rachel P. Gaither, Yetis Gultekin, Dudley W. Lamming, Ömer H. Yilmaz, Pekka Katajisto, Maria M. Mihaylova, David M. Sabatini
Publikováno v:
Aging Cell
Wiley Blackwell
Wiley Blackwell
Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2a1ab6d08eb04c64f60098fc5ce3d9
http://europepmc.org/articles/PMC4172536
http://europepmc.org/articles/PMC4172536