Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Emma L. Ashby"'
Autor:
Susan M. Hutson, Marta Kierzkowska, Patrick G. Kehoe, Myra E. Conway, Jonathon Hull, Emma L. Ashby
Publikováno v:
Ashby, E L, Kierzkowska, M, Hull, J, Kehoe, P G, Hutson, S M & Conway, M E 2016, ' Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia ', Neurochemical Research . https://doi.org/10.1007/s11064-016-1855-7
Neurochemical Research
Neurochemical Research
Cytosolic and mitochondrial human branched chain aminotransferase (hBCATc and hBCATm, respectively) play an integral role in brain glutamate metabolism. Regional increased levels of hBCATc in the CA1 and CA4 region of Alzheimer's disease (AD) brain t
Publikováno v:
Journal of Alzheimer's Disease. 50:1191-1203
Epidemiological data associate hypertension with a predisposition to Alzheimer's disease (AD), and a number of postmortem and in vivo studies also demonstrate that hypertension increases amyloid-β (Aβ) pathology. In contrast, anti-hypertensive medi
Publikováno v:
Neuropathology and Applied Neurobiology. 41:428-444
Aims Deposition of amyloid beta (Aβ) in the brain is one of the defining abnormalities of Alzheimer's disease (AD). Phosphorylation of Aβ at serine 8 (pAβ) has been implicated in its aggregation in vitro and pAβ level has been shown to be signifi
Autor:
Patrick G. Kehoe, Emma L. Ashby
Publikováno v:
Expert Opinion on Investigational Drugs. 22:1229-1242
Hypertension is a modifiable risk factor for Alzheimer's disease (AD) and other dementias. Yet, despite this well-documented association, few of the current strategies to treat AD are directed at this possible target. The renin-aldosterone angiotensi
Publikováno v:
Neurobiology of Aging. 33:1345-1355
Decreased cerebral blood flow and blood-brain barrier disruption are features of Alzheimer's disease (AD). The plasma kallikrein-kinin system modulates cerebrovascular tone through release of vasoactive bradykinin (BK). Cerebroventricular infusion of
Autor:
Emma L. Ashby, Charlotte E. Teunissen, Majon Muller, Mirjam I. Geerlings, Hadassa M. Jochemsen, Ruth E. Jones, Mike P. Wattjes, Philip Scheltens, Wiesje M. van der Flier, Patrick G. Kehoe
Publikováno v:
Journal of Alzheimer's Disease, 44(1), 153-162. IOS Press
Journal of Alzheimer's Disease, 44(1), 153-162
Jochemsen, H M, van der Flier, W M, Ashby, E L, Teunissen, C E, Jones, R E, Wattjes, M P, Scheltens, P, Geerlings, M I, Kehoe, P G & Muller, M 2015, ' Angiotensin-Converting Enzyme in Cerebrospinal Fluid and Risk of Brain Atrophy ', Journal of Alzheimer's Disease, vol. 44, no. 1, pp. 153-162 . https://doi.org/10.3233/JAD-131496
Journal of Alzheimer's Disease, 44(1), 153-162
Jochemsen, H M, van der Flier, W M, Ashby, E L, Teunissen, C E, Jones, R E, Wattjes, M P, Scheltens, P, Geerlings, M I, Kehoe, P G & Muller, M 2015, ' Angiotensin-Converting Enzyme in Cerebrospinal Fluid and Risk of Brain Atrophy ', Journal of Alzheimer's Disease, vol. 44, no. 1, pp. 153-162 . https://doi.org/10.3233/JAD-131496
Background Higher angiotensin-converting enzyme (ACE) activity might increase the risk of Alzheimer's disease by increasing blood pressure, and subsequent development of cerebral small vessel disease (CSVD). Yet, it may also decrease this risk, as it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287e73d314813683f320a58e38c594b9
https://hdl.handle.net/1887/103147
https://hdl.handle.net/1887/103147
Publikováno v:
Brain Research. 1363:1-10
Human kallikrein-related peptidase 6 (KLK6) is highly expressed in the central nervous system. Although the physiological roles of this serine protease are unknown, in vitro substrates include amyloid precursor protein and components of the extracell
Autor:
Hadassa M. Jochemsen, Mirjam I. Geerlings, Wiesje M. van der Flier, Philip Scheltens, Majon Muller, Emma L. Ashby, Ruth E. Jones, Patrick G. Kehoe, Charlotte E. Teunissen
Publikováno v:
Alzheimer's Research and Therapy, 6(3)
Alzheimer's Research & Therapy, 6(3):27. BioMed Central
Alzheimer's Research & Therapy
Jochemsen, H M, Teunissen, C E, Ashby, E L, van der Flier, W M, Jones, R E, Geerlings, M I, Scheltens, P, Kehoe, P G & Muller, M 2014, ' The association of angiotensin-converting enzyme with biomarkers for Alzheimer's disease ', Alzheimer's Research & Therapy, vol. 6, no. 3, 27, pp. 27 . https://doi.org/10.1186/alzrt257
Alzheimer's Research & Therapy, 6(3):27. BioMed Central
Alzheimer's Research & Therapy
Jochemsen, H M, Teunissen, C E, Ashby, E L, van der Flier, W M, Jones, R E, Geerlings, M I, Scheltens, P, Kehoe, P G & Muller, M 2014, ' The association of angiotensin-converting enzyme with biomarkers for Alzheimer's disease ', Alzheimer's Research & Therapy, vol. 6, no. 3, 27, pp. 27 . https://doi.org/10.1186/alzrt257
Introduction Lower angiotensin-converting enzyme (ACE) activity could increase the risk of Alzheimer’s disease (AD) as ACE functions to degrade amyloid-β (Aβ). Therefore, we investigated whether ACE protein and activity levels in cerebrospinal fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5135e3a1b835852bf0a10d0e8140378b
http://hdl.handle.net/1887/103686
http://hdl.handle.net/1887/103686
Publikováno v:
Neuropathology and applied neurobiology. 41(4)
Deposition of amyloid beta (Aβ) in the brain is one of the defining abnormalities of Alzheimer's disease (AD). Phosphorylation of Aβ at serine 8 (pAβ) has been implicated in its aggregation in vitro and pAβ level has been shown to be significantl
Autor:
Jennifer C Palmer, Patrick G. Kehoe, Hannah Tayler, Seth Love, J Scott Miners, Emma L. Ashby, Laura Palmer
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 6 (2014)
Frontiers in Aging Neuroscience, Vol 6 (2014)
There is increasing evidence that deficient clearance of β-amyloid (Aβ) contributes to its accumulation in late-onset Alzheimer disease (AD). Several Aβ-degrading enzymes, including neprilysin (NEP), endothelin-converting enzyme (ECE), and angiote